DegronMD

Uniprot ID: Q86VQ1

Source protein: Glucocorticoid-induced transcript 1 protein

Source gene: GLCCI1

Class: DEG_SCF_TRCP1_1

Location: 393:398

E3 ligase: BTRC

DEGRON score: 0.9577

ASA_SCORE: 66.3333

COIL: 0.9327

CONS_SCORE: 0.6067

DSS_SCORE: 0.6615

HELIX: 0.0378

FCONS_SCORE: 0.9535

RIG_SCORE: 0.5334

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D389V	TCGA-91-6828	LUAD	TCGA	DSGSSS	DEG_SCF_TRCP1_1	0.2222
p.D389V	DO26150	LUAD	ICGC	DSGSSS	DEG_SCF_TRCP1_1	0.2222
p.D385N	TCGA-95-7948	LUAD	TCGA	DSGSSS	DEG_SCF_TRCP1_1	0.1111
p.D385N	DO25133	LUAD	ICGC	DSGSSS	DEG_SCF_TRCP1_1	0.1111
p.Y388C	TCGA-FD-A5C0	BLCA	TCGA	DSGSSS	DEG_SCF_TRCP1_1	0.1944
p.Y388C	DO44046	BLCA	ICGC	DSGSSS	DEG_SCF_TRCP1_1	0.1944
p.Y388C	SIDM01066	Melanoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	0.1944
p.Y388C	ACH-000650	Skin Cancer	CCLE	DSGSSS	DEG_SCF_TRCP1_1	0.1944
p.Y388C	IGR-37	skin	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	0.1944
p.D389N	DO228965	LICA	ICGC	DSGSSS	DEG_SCF_TRCP1_1	0.2222
p.G395W	DO229015	LICA	ICGC	DSGSSS	DEG_SCF_TRCP1_1	0.7825
p.R390C	DO229470	SKCA	ICGC	DSGSSS	DEG_SCF_TRCP1_1	0.25
p.P399Q	DO229272	THCA	ICGC	DSGSSS	DEG_SCF_TRCP1_1	0.3056
p.L400F	ACH-000786	Lymphoma	CCLE	DSGSSS	DEG_SCF_TRCP1_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13428	Treacle protein	DEG_SCF_TRCP1_1	931:936	DSGSSS	BTRC	0.9956	More...
Q8IYG6	Leucine-rich repeat-containing protein 56	DEG_SCF_TRCP1_1	460:465	DSGSSS	BTRC	0.9835	More...
Q96S38	Ribosomal protein S6 kinase delta-1	DEG_SCF_TRCP1_1	499:504	DSGSSS	BTRC	0.9876	More...
Q9C0H9	SRC kinase signaling inhibitor 1	DEG_SCF_TRCP1_1	512:517	DSGSSS	BTRC	0.9672	More...
Q9H7S9	Zinc finger protein 703	DEG_SCF_TRCP1_1	169:174	DSGSSS	BTRC	0.9995	More...
Q9NQ76	Matrix extracellular phosphoglycoprotein	DEG_SCF_TRCP1_1	515:520	DSGSSS	BTRC	0.9943	More...
Q9Y4G8	Rap guanine nucleotide exchange factor 2	DEG_SCF_TRCP1_1	53:58	DSGSSS	BTRC	0.9394	More...
Q9C0H5	Rho GTPase-activating protein 39	DEG_SCF_TRCP1_1	168:173	DSGSSS	BTRC	0.9988	More...
Q86VQ1	Glucocorticoid-induced transcript 1 protein	DEG_SCF_TRCP1_1	393:398	DSGSSS	BTRC	0.9577	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons