DegronMD

Uniprot ID: Q9NQ76

Source protein: Matrix extracellular phosphoglycoprotein

Source gene: MEPE

Class: DEG_SCF_TRCP1_1

Location: 515:520

E3 ligase: BTRC

DEGRON score: 0.9943

ASA_SCORE: 88.1833

COIL: 0.9635

CONS_SCORE: 0.9097

DSS_SCORE: 0.825

HELIX: 0.0263

FCONS_SCORE: 1.1415

RIG_SCORE: 0.4326

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S510I	TCGA-49-4488	LUAD	TCGA	DSGSSS	DEG_SCF_TRCP1_1	0.1944
p.S510I	DO24750	LUAD	ICGC	DSGSSS	DEG_SCF_TRCP1_1	0.1944
p.D509G	TCGA-A6-5665	COAD	TCGA	DSGSSS	DEG_SCF_TRCP1_1	0.1667
p.R505C	TCGA-B5-A11H	UCEC	TCGA	DSGSSS	DEG_SCF_TRCP1_1	0.0556
p.S520I	DO229018	LICA	ICGC	DSGSSS	DEG_SCF_TRCP1_1	0.8453
p.S520I	DO229028	LICA	ICGC	DSGSSS	DEG_SCF_TRCP1_1	0.8453
p.G521V	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	0.3056
p.G521V	SU-DHL-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	0.3056
p.R512W	SIDM00656	Burkitt's Lymphoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	0.25
p.R512W	SIDM00633	Breast Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	0.25
p.R512W	SIDM00660	Colorectal Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	0.25
p.R512W	SIDM00032	Bladder Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	0.25
p.R512W	SIDM00760	Small Cell Lung Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	0.25
p.R512W	SIDM00641	Burkitt's Lymphoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	0.25
p.R512W	SIDM01752	Pancreatic Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	0.25
p.Q518H	SIDM00656	Burkitt's Lymphoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	0.7582
p.Q518H	SIDM00633	Breast Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	0.7582
p.Q518H	SIDM01112	Osteosarcoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	0.7582
p.Q518H	SIDM01099	Neuroblastoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	0.7582
p.Q518H	SIDM00032	Bladder Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	0.7582
p.Q518H	SIDM00760	Small Cell Lung Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	0.7582
p.Q518H	SIDM00641	Burkitt's Lymphoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	0.7582
p.Q518H	SIDM01752	Pancreatic Carcinoma	GDSC	DSGSSS	DEG_SCF_TRCP1_1	0.7582
p.S520G	ACH-000997	Colon/Colorectal Cancer	CCLE	DSGSSS	DEG_SCF_TRCP1_1	0.8104
p.S520G	HCT-15	large_intestine	COSMIC	DSGSSS	DEG_SCF_TRCP1_1	0.8104

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13428	Treacle protein	DEG_SCF_TRCP1_1	931:936	DSGSSS	BTRC	0.9956	More...
Q8IYG6	Leucine-rich repeat-containing protein 56	DEG_SCF_TRCP1_1	460:465	DSGSSS	BTRC	0.9835	More...
Q96S38	Ribosomal protein S6 kinase delta-1	DEG_SCF_TRCP1_1	499:504	DSGSSS	BTRC	0.9876	More...
Q9C0H9	SRC kinase signaling inhibitor 1	DEG_SCF_TRCP1_1	512:517	DSGSSS	BTRC	0.9672	More...
Q9H7S9	Zinc finger protein 703	DEG_SCF_TRCP1_1	169:174	DSGSSS	BTRC	0.9995	More...
Q9NQ76	Matrix extracellular phosphoglycoprotein	DEG_SCF_TRCP1_1	515:520	DSGSSS	BTRC	0.9943	More...
Q9Y4G8	Rap guanine nucleotide exchange factor 2	DEG_SCF_TRCP1_1	53:58	DSGSSS	BTRC	0.9394	More...
Q9C0H5	Rho GTPase-activating protein 39	DEG_SCF_TRCP1_1	168:173	DSGSSS	BTRC	0.9988	More...
Q86VQ1	Glucocorticoid-induced transcript 1 protein	DEG_SCF_TRCP1_1	393:398	DSGSSS	BTRC	0.9577	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGSSS

Degron related mutations and impact score

Drug responses associated with MEPE mutations

All proteins holding degron of DSGSSS