DegronMD

Uniprot ID: Q13428

Source protein: Treacle protein

Source gene: TCOF1

Class: DEG_SCF_FBW7_1

Location: 1207:1212

E3 ligase: FBXW7

DEGRON score: 0.9908

ASA_SCORE: 87.7667

COIL: 0.9567

CONS_SCORE: 0.448

DSS_SCORE: 0.5566

HELIX: 0.0112

FCONS_SCORE: 0.9123

RIG_SCORE: 0.6637

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y1206D	TCGA-AG-A002	READ	TCGA	MTPGLT	DEG_SCF_FBW7_1	0.75
p.S1199F	TCGA-EE-A2MS	SKCM	TCGA	MTPGLT	DEG_SCF_FBW7_1	0.5556
p.A1199V	DO2186	BRCA	ICGC	MTPGLT	DEG_SCF_FBW7_1	0.5556
p.A1200T	DO230312	COCA	ICGC	MTPGLT	DEG_SCF_FBW7_1	0.1389
p.D1205H	DO50828	LICA	ICGC	MTPGLT	DEG_SCF_FBW7_1	0.2778
p.A1199T	DO227546	PBCA	ICGC	MTPGLT	DEG_SCF_FBW7_1	0.5556
p.P1221H	DO47491	SKCM	ICGC	MTPGLT	DEG_SCF_FBW7_1	0.0833
p.A1213V	DO38328	STAD	ICGC	MTPGLT	DEG_SCF_FBW7_1	0.3056
p.T1212I	SIDM00854	Burkitt's Lymphoma	GDSC	MTPGLT	DEG_SCF_FBW7_1	0.7078
p.T1212I	GA-10	haematopoietic_and_lymphoid_tissue	COSMIC	MTPGLT	DEG_SCF_FBW7_1	0.7078
p.M1207K	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	MTPGLT	DEG_SCF_FBW7_1	0.8062
p.M1207K	SIDM00826	Colorectal Carcinoma	GDSC	MTPGLT	DEG_SCF_FBW7_1	0.8062
p.M1207K	SIDM00823	Colorectal Carcinoma	GDSC	MTPGLT	DEG_SCF_FBW7_1	0.8062
p.S1201F	SIDM00532	Glioma	GDSC	MTPGLT	DEG_SCF_FBW7_1	0.1667
p.S1201F	MOG-G-CCM	central_nervous_system	COSMIC	MTPGLT	DEG_SCF_FBW7_1	0.1667
p.Q1214R	ACH-000427	Gastric Cancer	CCLE	MTPGLT	DEG_SCF_FBW7_1	0.2778
p.Q1214R	NCI-N87	stomach	COSMIC	MTPGLT	DEG_SCF_FBW7_1	0.2778
p.L1219F	ACH-000679	Esophageal Cancer	CCLE	MTPGLT	DEG_SCF_FBW7_1	0.1389
p.L1219F	OE19	oesophagus	COSMIC	MTPGLT	DEG_SCF_FBW7_1	0.1389
p.L1198P	ACH-000998	Colon/Colorectal Cancer	CCLE	MTPGLT	DEG_SCF_FBW7_1	0.0833
p.L1198P	CW-2	large_intestine	COSMIC	MTPGLT	DEG_SCF_FBW7_1	0.0833
p.D1202E	ACH-001081	Colon/Colorectal Cancer	CCLE	MTPGLT	DEG_SCF_FBW7_1	0.1944
p.D1202E	HCC2998	large_intestine	COSMIC	MTPGLT	DEG_SCF_FBW7_1	0.1944
p.T1213I	GA-10	haematopoietic_and_lymphoid_tissue	COSMIC	MTPGLT	DEG_SCF_FBW7_1	0.3056
p.Q1213R	NCI-N87	stomach	COSMIC	MTPGLT	DEG_SCF_FBW7_1	0.3056
p.D1201E	HCC2998	large_intestine	COSMIC	MTPGLT	DEG_SCF_FBW7_1	0.1667
p.L1197P	CW-2	large_intestine	COSMIC	MTPGLT	DEG_SCF_FBW7_1	0.0556
p.L1218F	OE19	oesophagus	COSMIC	MTPGLT	DEG_SCF_FBW7_1	0.1667
p.S1202F	MOG-G-CCM	central_nervous_system	COSMIC	MTPGLT	DEG_SCF_FBW7_1	0.1944
p.Q1209R	CW-2	large_intestine	COSMIC	MTPGLT	DEG_SCF_FBW7_1	0.7329
p.Q1208R	CW-2	large_intestine	COSMIC	MTPGLT	DEG_SCF_FBW7_1	0.7329

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MTPGLT

Degron related mutations and impact score

Drug responses associated with TCOF1 mutations

All proteins holding degron of MTPGLT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13428	Treacle protein	DEG_SCF_FBW7_1	1207:1212	MTPGLT	FBXW7	0.9908	More...