DegronMD

Uniprot ID: Q13428

Source protein: Treacle protein

Source gene: TCOF1

Class: DEG_SCF_FBW7_1

Location: 1172:1179

E3 ligase: FBXW7

DEGRON score: 0.8241

ASA_SCORE: 95.9875

COIL: 0.9544

CONS_SCORE: 0.3576

DSS_SCORE: 0.734

HELIX: 0.0226

FCONS_SCORE: 0.9284

RIG_SCORE: 0.6014

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1166T	TCGA-85-7844	LUSC	TCGA	LGPTPSRT	DEG_SCF_FBW7_1	0.1667
p.Q1164H	TCGA-D1-A2G0	UCEC	TCGA	LGPTPSRT	DEG_SCF_FBW7_1	0.1111
p.P1176S	TCGA-D6-6516	HNSC	TCGA	LGPTPSRT	DEG_SCF_FBW7_1	0.6752
p.P1176S	TCGA-EB-A431	SKCM	TCGA	LGPTPSRT	DEG_SCF_FBW7_1	0.6752
p.P1176S	TCGA-FS-A4F5	SKCM	TCGA	LGPTPSRT	DEG_SCF_FBW7_1	0.6752
p.P1177R	DO230550	LUSC	ICGC	LGPTPSRT	DEG_SCF_FBW7_1	0.7512
p.S1162F	DO37567	SKCM	ICGC	LGPTPSRT	DEG_SCF_FBW7_1	0.0556
p.T1171M	SIDM00602	Gastric Carcinoma	GDSC	LGPTPSRT	DEG_SCF_FBW7_1	0.75
p.T1171M	IM-95	stomach	COSMIC	LGPTPSRT	DEG_SCF_FBW7_1	0.75
p.T1175I	ACH-000162	Lymphoma	CCLE	LGPTPSRT	DEG_SCF_FBW7_1	0.8189
p.T1175I	GA-10	haematopoietic_and_lymphoid_tissue	COSMIC	LGPTPSRT	DEG_SCF_FBW7_1	0.8189
p.S1164F	MOG-G-CCM	central_nervous_system	COSMIC	LGPTPSRT	DEG_SCF_FBW7_1	0.1111
p.S1163F	MOG-G-CCM	central_nervous_system	COSMIC	LGPTPSRT	DEG_SCF_FBW7_1	0.0833
p.D1162E	HCC2998	large_intestine	COSMIC	LGPTPSRT	DEG_SCF_FBW7_1	0.0556
p.L1179F	OE19	oesophagus	COSMIC	LGPTPSRT	DEG_SCF_FBW7_1	0.6981
p.Q1175R	NCI-N87	stomach	COSMIC	LGPTPSRT	DEG_SCF_FBW7_1	0.7329
p.D1163E	HCC2998	large_intestine	COSMIC	LGPTPSRT	DEG_SCF_FBW7_1	0.0833
p.Q1174R	NCI-N87	stomach	COSMIC	LGPTPSRT	DEG_SCF_FBW7_1	0.7329
p.L1180F	OE19	oesophagus	COSMIC	LGPTPSRT	DEG_SCF_FBW7_1	0.3056
p.T1170M	IM-95	stomach	COSMIC	LGPTPSRT	DEG_SCF_FBW7_1	0.2778
p.T1174I	GA-10	haematopoietic_and_lymphoid_tissue	COSMIC	LGPTPSRT	DEG_SCF_FBW7_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13428	Treacle protein	DEG_SCF_FBW7_1	1172:1179	LGPTPSRT	FBXW7	0.8241	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons