DegronMD - Q92738(USP6NL)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S774N	TCGA-34-5239	LUSC	TCGA	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	769:782	Mutation altering degron motif	0.7069
p.S774N	TCGA-34-5239	LUSC	TCGA	LAPFQD	LIG_APCC_ABBA_1	769:774	Mutation altering degron motif	0.7069
p.S815N	TCGA-50-5049	LUAD	TCGA	PPAY	ITCH	809:812	Mutation rewiring degron network	0.25
p.S815N	DO23705	LUAD	ICGC	PPAY	ITCH	809:812	Mutation rewiring degron network	0.25
p.S815N	SIDM00025	Head and Neck Carcinoma	GDSC	PPAY	ITCH	809:812	Mutation rewiring degron network	0.25
p.S815N	UDSCC2	upper aerodigestive tract	COSMIC	PPAY	ITCH	809:812	Mutation rewiring degron network	0.25
p.A787V	TCGA-51-4081	LUSC	TCGA	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	769:782	Mutation rewiring degron network	0.1944
p.G638V	TCGA-86-8358	LUAD	TCGA	PPVY	ITCH	635:638	Mutation altering degron motif	0.7532
p.G642W	TCGA-A3-A6NL	KIRC	TCGA	PPSY	ITCH	629:632	Mutation blocking phosphorylation signal	0.5
p.G642W	TCGA-A3-A6NL	KIRC	TCGA	PPVY	ITCH	635:638	Mutation blocking phosphorylation signal	0.6667
p.S774G	TCGA-AP-A056	UCEC	TCGA	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	769:782	Mutation altering degron motif	0.6993
p.S774G	TCGA-AP-A056	UCEC	TCGA	LAPFQD	LIG_APCC_ABBA_1	769:774	Mutation altering degron motif	0.6993
p.A630P	TCGA-D8-A1XK	BRCA	TCGA	PPSY	ITCH	629:632	Mutation altering degron motif	0.7503
p.A630P	DO4749	BRCA	ICGC	PPSY	ITCH	629:632	Mutation altering degron motif	0.7503
p.A787T	TCGA-DF-A2KN	UCEC	TCGA	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	769:782	Mutation rewiring degron network	0.1944
p.A787T	DO233935	GACA	ICGC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	769:782	Mutation rewiring degron network	0.1944
p.A787T	DO223282	UCEC	ICGC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	769:782	Mutation rewiring degron network	0.1944
p.P816S	TCGA-EE-A180	SKCM	TCGA	PPAY	ITCH	809:812	Mutation rewiring degron network	0.2222
p.P816S	DO47537	SKCM	ICGC	PPAY	ITCH	809:812	Mutation rewiring degron network	0.2222
p.P633S	TCGA-EE-A2A0	SKCM	TCGA	PPSY	ITCH	629:632	Mutation blocking phosphorylation signal	0.75
p.P633S	TCGA-EE-A2A0	SKCM	TCGA	PPVY	ITCH	635:638	Mutation blocking phosphorylation signal	0.7222
p.P633S	TCGA-EE-A2GN	SKCM	TCGA	PPSY	ITCH	629:632	Mutation blocking phosphorylation signal	0.75
p.P633S	TCGA-EE-A2GN	SKCM	TCGA	PPVY	ITCH	635:638	Mutation blocking phosphorylation signal	0.7222
p.P633S	TCGA-GF-A6C9	SKCM	TCGA	PPSY	ITCH	629:632	Mutation blocking phosphorylation signal	0.75
p.P633S	TCGA-GF-A6C9	SKCM	TCGA	PPVY	ITCH	635:638	Mutation blocking phosphorylation signal	0.7222
p.P633S	DO37896	SKCM	ICGC	PPSY	ITCH	629:632	Mutation blocking phosphorylation signal	0.75
p.P633S	DO37896	SKCM	ICGC	PPVY	ITCH	635:638	Mutation blocking phosphorylation signal	0.7222
p.P633S	DO37439	SKCM	ICGC	PPSY	ITCH	629:632	Mutation blocking phosphorylation signal	0.75
p.P633S	DO37439	SKCM	ICGC	PPVY	ITCH	635:638	Mutation blocking phosphorylation signal	0.7222
p.P633S	DO51254	SKCM	ICGC	PPSY	ITCH	629:632	Mutation blocking phosphorylation signal	0.75
p.P633S	DO51254	SKCM	ICGC	PPVY	ITCH	635:638	Mutation blocking phosphorylation signal	0.7222
p.R631L	TCGA-ER-A19H	SKCM	TCGA	PPSY	ITCH	629:632	Mutation altering degron motif	0.8428
p.S808L	TCGA-FW-A3R5	SKCM	TCGA	PPAY	ITCH	809:812	Mutation rewiring degron network	0.3056
p.P802L	TCGA-FW-A3R5	SKCM	TCGA	PPAY	ITCH	809:812	Mutation blocking phosphorylation signal	0.5833
p.P802S	TCGA-FW-A3R5	SKCM	TCGA	PPAY	ITCH	809:812	Mutation blocking phosphorylation signal	0.5833
p.P633L	TCGA-GN-A266	SKCM	TCGA	PPSY	ITCH	629:632	Mutation blocking phosphorylation signal	0.75
p.P633L	TCGA-GN-A266	SKCM	TCGA	PPVY	ITCH	635:638	Mutation blocking phosphorylation signal	0.7222
p.S648F	TCGA-GU-A764	BLCA	TCGA	PPVY	ITCH	635:638	Mutation blocking phosphorylation signal	0.5
p.P647L	TCGA-VR-AA7B	ESCA	TCGA	PPVY	ITCH	635:638	Mutation rewiring degron network	0.0833
p.P646S	DO228423	BRCA	ICGC	PPVY	ITCH	635:638	Mutation rewiring degron network	0.1111
p.R775H	DO227996	COCA	ICGC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	769:782	Mutation altering degron motif	0.8244
p.V803M	DO234401	ESAD	ICGC	PPAY	ITCH	809:812	Mutation rewiring degron network	0.1667
p.G648W	DO50458	KIRC	ICGC	PPVY	ITCH	635:638	Mutation blocking phosphorylation signal	0.5
p.P639Q	DO229029	LICA	ICGC	PPSY	ITCH	629:632	Mutation rewiring degron network	0.1389
p.P639Q	DO229029	LICA	ICGC	PPVY	ITCH	635:638	Mutation rewiring degron network	0.3056
p.R775S	DO229038	LICA	ICGC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	769:782	Mutation altering degron motif	0.7427
p.G644V	DO25471	LUAD	ICGC	PPVY	ITCH	635:638	Mutation substituting flanking lysine	0.2778
p.S780N	DO27660	LUSC	ICGC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	769:782	Mutation altering degron motif	0.7069
p.P820L	DO220886	MELA	ICGC	PPAY	ITCH	809:812	Mutation rewiring degron network	0.1111
p.QG765QR	DO222662	MELA	ICGC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	769:782	Mutation blocking phosphorylation signal	0.4444
p.QG765QR	DO222662	MELA	ICGC	LAPFQD	LIG_APCC_ABBA_1	769:774	Mutation blocking phosphorylation signal	0.4444
p.P809L	DO46370	OV	ICGC	PPAY	ITCH	809:812	Mutation altering degron motif	0.7582
p.Q631H	DO232224	PBCA	ICGC	PPSY	ITCH	629:632	Mutation altering degron motif	0.7582
p.R637L	DO47299	SKCM	ICGC	PPVY	ITCH	635:638	Mutation altering degron motif	0.8428
p.P808L	DO37406	SKCM	ICGC	PPAY	ITCH	809:812	Mutation rewiring degron network	0.3056
p.P808L	REH	haematopoietic and lymphoid tissue	COSMIC	PPAY	ITCH	809:812	Mutation rewiring degron network	0.3056
p.P808S	DO37406	SKCM	ICGC	PPAY	ITCH	809:812	Mutation rewiring degron network	0.3056
p.S814L	DO37406	SKCM	ICGC	PPAY	ITCH	809:812	Mutation blocking phosphorylation signal	0.7222
p.P639L	DO37432	SKCM	ICGC	PPSY	ITCH	629:632	Mutation rewiring degron network	0.1389
p.P639L	DO37432	SKCM	ICGC	PPVY	ITCH	635:638	Mutation rewiring degron network	0.3056
p.S780G	DO43971	UCEC	ICGC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	769:782	Mutation altering degron motif	0.6993
p.D772Y	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	769:782	Mutation altering degron motif	0.7325
p.D772Y	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LAPFQD	LIG_APCC_ABBA_1	769:774	Mutation altering degron motif	0.7325
p.D772Y	DND-41	haematopoietic and lymphoid tissue	COSMIC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	769:782	Mutation altering degron motif	0.7325
p.D772Y	DND-41	haematopoietic and lymphoid tissue	COSMIC	LAPFQD	LIG_APCC_ABBA_1	769:774	Mutation altering degron motif	0.7325
p.A640S	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPSY	ITCH	629:632	Mutation rewiring degron network	0.1111
p.A640S	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPVY	ITCH	635:638	Mutation rewiring degron network	0.2778
p.A640S	SU-DHL-8	NS	COSMIC	PPSY	ITCH	629:632	Mutation rewiring degron network	0.1111
p.A640S	SU-DHL-8	NS	COSMIC	PPVY	ITCH	635:638	Mutation rewiring degron network	0.2778
p.G776D	SIDM00683	Prostate Carcinoma	GDSC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	769:782	Mutation altering degron motif	0.6087
p.G776D	SIDM00534	Colorectal Carcinoma	GDSC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	769:782	Mutation altering degron motif	0.6087
p.G776D	HT-115	large intestine	COSMIC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	769:782	Mutation altering degron motif	0.6087
p.G776D	LNCaP-Clone-FGC	prostate	COSMIC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	769:782	Mutation altering degron motif	0.6087
p.P820S	SIDM00007	Other Solid Cancers	GDSC	PPAY	ITCH	809:812	Mutation rewiring degron network	0.1111
p.P820S	MCC13	skin	COSMIC	PPAY	ITCH	809:812	Mutation rewiring degron network	0.1111
p.T764M	SIDM00329	Hodgkin's Lymphoma	GDSC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	769:782	Mutation blocking phosphorylation signal	0.6389
p.T764M	SIDM00329	Hodgkin's Lymphoma	GDSC	LAPFQD	LIG_APCC_ABBA_1	769:774	Mutation blocking phosphorylation signal	0.6389
p.T764M	SIDM01106	Melanoma	GDSC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	769:782	Mutation blocking phosphorylation signal	0.6389
p.T764M	SIDM01106	Melanoma	GDSC	LAPFQD	LIG_APCC_ABBA_1	769:774	Mutation blocking phosphorylation signal	0.6389
p.T764M	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	769:782	Mutation blocking phosphorylation signal	0.6389
p.T764M	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	LAPFQD	LIG_APCC_ABBA_1	769:774	Mutation blocking phosphorylation signal	0.6389
p.T764M	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	769:782	Mutation blocking phosphorylation signal	0.6389
p.T764M	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	LAPFQD	LIG_APCC_ABBA_1	769:774	Mutation blocking phosphorylation signal	0.6389
p.P816A	SIDM01134	Small Cell Lung Carcinoma	GDSC	PPAY	ITCH	809:812	Mutation rewiring degron network	0.2222
p.P816A	NCI-H841	lung	COSMIC	PPAY	ITCH	809:812	Mutation rewiring degron network	0.2222
p.A814T	SIDM00282	Colorectal Carcinoma	GDSC	PPAY	ITCH	809:812	Mutation blocking phosphorylation signal	0.7222
p.A814T	CW-2	large intestine	COSMIC	PPAY	ITCH	809:812	Mutation blocking phosphorylation signal	0.7222
p.S817C	SIDM00747	Non-Small Cell Lung Carcinoma	GDSC	PPAY	ITCH	809:812	Mutation rewiring degron network	0.1944
p.S817C	NCI-H1623	lung	COSMIC	PPAY	ITCH	809:812	Mutation rewiring degron network	0.1944
p.R761K	SIDM01735	Biliary Tract Carcinoma	GDSC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	769:782	Mutation rewiring degron network	0.1111
p.R761K	SIDM01735	Biliary Tract Carcinoma	GDSC	LAPFQD	LIG_APCC_ABBA_1	769:774	Mutation rewiring degron network	0.1111
p.T648I	ACH-000237	Ovarian Cancer	CCLE	PPVY	ITCH	635:638	Mutation blocking phosphorylation signal	0.5
p.T648I	ACH-000524	Ovarian Cancer	CCLE	PPVY	ITCH	635:638	Mutation blocking phosphorylation signal	0.5
p.T648I	ACH-001495	Endometrial/Uterine Cancer	CCLE	PPVY	ITCH	635:638	Mutation blocking phosphorylation signal	0.5
p.T648I	ACH-001850	Gallbladder Cancer	CCLE	PPVY	ITCH	635:638	Mutation blocking phosphorylation signal	0.5
p.T648I	ACH-001856	Bile Duct Cancer	CCLE	PPVY	ITCH	635:638	Mutation blocking phosphorylation signal	0.5
p.P799A	ACH-000292	Lung Cancer	CCLE	PPAY	ITCH	809:812	Mutation rewiring degron network	0.0556
p.P799A	NCI-H841	lung	COSMIC	PPAY	ITCH	809:812	Mutation rewiring degron network	0.0556
p.L820I	ACH-000481	Lung Cancer	CCLE	PPAY	ITCH	809:812	Mutation rewiring degron network	0.1111
p.L820I	NCI-H2170	lung	COSMIC	PPAY	ITCH	809:812	Mutation rewiring degron network	0.1111
p.A623S	ACH-000656	Lymphoma	CCLE	PPSY	ITCH	629:632	Mutation rewiring degron network	0.1667
p.A623S	SU-DHL-8	NS	COSMIC	PPSY	ITCH	629:632	Mutation rewiring degron network	0.1667
p.S633N	ACH-000941	Endometrial/Uterine Cancer	CCLE	PPSY	ITCH	629:632	Mutation blocking phosphorylation signal	0.75
p.S633N	ACH-000941	Endometrial/Uterine Cancer	CCLE	PPVY	ITCH	635:638	Mutation blocking phosphorylation signal	0.7222
p.S633N	ACH-001517	Endometrial/Uterine Cancer	CCLE	PPSY	ITCH	629:632	Mutation blocking phosphorylation signal	0.75
p.S633N	ACH-001517	Endometrial/Uterine Cancer	CCLE	PPVY	ITCH	635:638	Mutation blocking phosphorylation signal	0.7222
p.S633N	HEC-1	endometrium	COSMIC	PPSY	ITCH	629:632	Mutation blocking phosphorylation signal	0.75
p.S633N	HEC-1	endometrium	COSMIC	PPVY	ITCH	635:638	Mutation blocking phosphorylation signal	0.7222
p.G759D	ACH-000977	lymph node	CCLE	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	769:782	Mutation rewiring degron network	0.0556
p.G759D	ACH-000977	lymph node	CCLE	LAPFQD	LIG_APCC_ABBA_1	769:774	Mutation rewiring degron network	0.0556
p.G759D	ACH-000986	Colon/Colorectal Cancer	CCLE	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	769:782	Mutation rewiring degron network	0.0556
p.G759D	ACH-000986	Colon/Colorectal Cancer	CCLE	LAPFQD	LIG_APCC_ABBA_1	769:774	Mutation rewiring degron network	0.0556
p.G759D	HT-115	large intestine	COSMIC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	769:782	Mutation rewiring degron network	0.0556
p.G759D	HT-115	large intestine	COSMIC	LAPFQD	LIG_APCC_ABBA_1	769:774	Mutation rewiring degron network	0.0556
p.G759D	LNCaP-Clone-FGC	prostate	COSMIC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	769:782	Mutation rewiring degron network	0.0556
p.G759D	LNCaP-Clone-FGC	prostate	COSMIC	LAPFQD	LIG_APCC_ABBA_1	769:774	Mutation rewiring degron network	0.0556
p.P803S	ACH-001550	Skin Cancer	CCLE	PPAY	ITCH	809:812	Mutation rewiring degron network	0.1667
p.P803S	MCC13	skin	COSMIC	PPAY	ITCH	809:812	Mutation rewiring degron network	0.1667
p.S800C	NCI-H1623	lung	COSMIC	PPAY	ITCH	809:812	Mutation rewiring degron network	0.0833
p.P822A	NCI-H841	lung	COSMIC	PPAY	ITCH	809:812	Mutation rewiring degron network	0.0556
p.G782D	HT-115	large intestine	COSMIC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	769:782	Mutation altering degron motif	0.7198
p.G782D	LNCaP-Clone-FGC	prostate	COSMIC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	769:782	Mutation altering degron motif	0.7198
p.A646S	SU-DHL-8	NS	COSMIC	PPVY	ITCH	635:638	Mutation rewiring degron network	0.1111
p.D778Y	DND-41	haematopoietic and lymphoid tissue	COSMIC	LAPFQDHGLPAVSV	DEG_ODPH_VHL_1	769:782	Mutation altering degron motif	0.7325
p.S821N	UDSCC2	upper aerodigestive tract	COSMIC	PPAY	ITCH	809:812	Mutation rewiring degron network	0.0833
p.A820T	CW-2	large intestine	COSMIC	PPAY	ITCH	809:812	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

USP6NL

UniProt ID: Q92738

Entrez ID: 9712

Protein name: USP6 N-terminal-like protein (Related to the N-terminus of tre) (RN-tre)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for USP6NL in