DegronMD

Uniprot ID: Q92738

Source protein: USP6 N-terminal-like protein

Source gene: USP6NL

Class: LIG_APCC_ABBA_1

Location: 769:774

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9897

ASA_SCORE: 79.3667

COIL: 0.7477

CONS_SCORE: 0.2256

DSS_SCORE: 0.3568

HELIX: 0.1692

FCONS_SCORE: 0.9057

RIG_SCORE: 0.7367

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S774N	TCGA-34-5239	LUSC	TCGA	LAPFQD	LIG_APCC_ABBA_1	0.7069
p.S774G	TCGA-AP-A056	UCEC	TCGA	LAPFQD	LIG_APCC_ABBA_1	0.6993
p.QG765QR	DO222662	MELA	ICGC	LAPFQD	LIG_APCC_ABBA_1	0.4444
p.D772Y	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LAPFQD	LIG_APCC_ABBA_1	0.7325
p.D772Y	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	LAPFQD	LIG_APCC_ABBA_1	0.7325
p.T764M	SIDM00329	Hodgkin's Lymphoma	GDSC	LAPFQD	LIG_APCC_ABBA_1	0.6389
p.T764M	SIDM01106	Melanoma	GDSC	LAPFQD	LIG_APCC_ABBA_1	0.6389
p.T764M	SIDM00758	Non-Small Cell Lung Carcinoma	GDSC	LAPFQD	LIG_APCC_ABBA_1	0.6389
p.T764M	SIDM00757	Non-Small Cell Lung Carcinoma	GDSC	LAPFQD	LIG_APCC_ABBA_1	0.6389
p.R761K	SIDM01735	Biliary Tract Carcinoma	GDSC	LAPFQD	LIG_APCC_ABBA_1	0.1111
p.G759D	ACH-000977	lymph_node	CCLE	LAPFQD	LIG_APCC_ABBA_1	0.0556
p.G759D	ACH-000986	Colon/Colorectal Cancer	CCLE	LAPFQD	LIG_APCC_ABBA_1	0.0556
p.G759D	HT-115	large_intestine	COSMIC	LAPFQD	LIG_APCC_ABBA_1	0.0556
p.G759D	LNCaP-Clone-FGC	prostate	COSMIC	LAPFQD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92738	USP6 N-terminal-like protein	LIG_APCC_ABBA_1	769:774	LAPFQD	APC,CDC20,FZR1	0.9897	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons