DegronMD

Uniprot ID: Q92738

Source protein: USP6 N-terminal-like protein

Source gene: USP6NL

Class: ITCH

Location: 635:638

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9985

ASA_SCORE: 80.375

COIL: 0.8798

CONS_SCORE: 0.2134

DSS_SCORE: 0.6246

HELIX: 0.0248

FCONS_SCORE: 1.0772

RIG_SCORE: 0.579

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G638V	TCGA-86-8358	LUAD	TCGA	PPVY	ITCH	0.7532
p.G642W	TCGA-A3-A6NL	KIRC	TCGA	PPVY	ITCH	0.6667
p.P633S	TCGA-EE-A2A0	SKCM	TCGA	PPVY	ITCH	0.7222
p.P633S	TCGA-EE-A2GN	SKCM	TCGA	PPVY	ITCH	0.7222
p.P633S	TCGA-GF-A6C9	SKCM	TCGA	PPVY	ITCH	0.7222
p.P633S	DO37896	SKCM	ICGC	PPVY	ITCH	0.7222
p.P633S	DO37439	SKCM	ICGC	PPVY	ITCH	0.7222
p.P633S	DO51254	SKCM	ICGC	PPVY	ITCH	0.7222
p.P633L	TCGA-GN-A266	SKCM	TCGA	PPVY	ITCH	0.7222
p.S648F	TCGA-GU-A764	BLCA	TCGA	PPVY	ITCH	0.5
p.P647L	TCGA-VR-AA7B	ESCA	TCGA	PPVY	ITCH	0.0833
p.P646S	DO228423	BRCA	ICGC	PPVY	ITCH	0.1111
p.G648W	DO50458	KIRC	ICGC	PPVY	ITCH	0.5
p.P639Q	DO229029	LICA	ICGC	PPVY	ITCH	0.3056
p.G644V	DO25471	LUAD	ICGC	PPVY	ITCH	0.2778
p.R637L	DO47299	SKCM	ICGC	PPVY	ITCH	0.8428
p.P639L	DO37432	SKCM	ICGC	PPVY	ITCH	0.3056
p.A640S	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	PPVY	ITCH	0.2778
p.A640S	SU-DHL-8	NS	COSMIC	PPVY	ITCH	0.2778
p.T648I	ACH-000237	Ovarian Cancer	CCLE	PPVY	ITCH	0.5
p.T648I	ACH-000524	Ovarian Cancer	CCLE	PPVY	ITCH	0.5
p.T648I	ACH-001495	Endometrial/Uterine Cancer	CCLE	PPVY	ITCH	0.5
p.T648I	ACH-001850	Gallbladder Cancer	CCLE	PPVY	ITCH	0.5
p.T648I	ACH-001856	Bile Duct Cancer	CCLE	PPVY	ITCH	0.5
p.S633N	ACH-000941	Endometrial/Uterine Cancer	CCLE	PPVY	ITCH	0.7222
p.S633N	ACH-001517	Endometrial/Uterine Cancer	CCLE	PPVY	ITCH	0.7222
p.S633N	HEC-1	endometrium	COSMIC	PPVY	ITCH	0.7222
p.A646S	SU-DHL-8	NS	COSMIC	PPVY	ITCH	0.1111

Drug responses associated with USP6NL mutations

All proteins holding degron of PPVY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NI15	Mesogenin-1	ITCH	152:155	PPVY	ITCH,NEDD4	0.9842	More...
O00358	Forkhead box protein E1	ITCH	209:212	PPVY	ITCH,NEDD4	0.6942	More...
O43760	Synaptogyrin-2	ITCH	221:224	PPVY	ITCH,NEDD4	0.9998	More...
O95696	Bromodomain-containing protein 1	ITCH	136:139	PPVY	ITCH,NEDD4	0.9995	More...
P05412	Transcription factor Jun	ITCH	167:170	PPVY	ITCH,NEDD4	0.9159	More...
P07202	Thyroid peroxidase	ITCH	178:181	PPVY	ITCH,NEDD4	0.6723	More...
P15311	Ezrin	ITCH	475:478	PPVY	ITCH,NEDD4	0.9955	More...
P16930	Fumarylacetoacetase	ITCH	187:190	PPVY	ITCH,NEDD4	0.9388	More...
P17275	Transcription factor JunB	ITCH	179:182	PPVY	ITCH,NEDD4	0.9876	More...
P19544	Wilms tumor protein	ITCH	197:200	PPVY	ITCH,NEDD4	0.9912	More...
P51817	cAMP-dependent protein kinase catalytic subunit PRKX	ITCH	41:44	PPVY	ITCH,NEDD4	0.9981	More...
P51841	Retinal guanylyl cyclase 2	ITCH	768:771	PPVY	ITCH,NEDD4	0.5364	More...
Q14738	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	ITCH	529:532	PPVY	ITCH,NEDD4	0.9915	More...
Q5TD94	Radial spoke head protein 4 homolog A	ITCH	663:666	PPVY	ITCH,NEDD4	0.999	More...
Q8IWI9	MAX gene-associated protein	ITCH	1388:1391	PPVY	ITCH,NEDD4	0.9681	More...
Q8IWZ3	Ankyrin repeat and KH domain-containing protein 1	ITCH	1039:1042	PPVY	ITCH,NEDD4	0.9027	More...
Q8IYH5	ZZ-type zinc finger-containing protein 3	ITCH	752:755	PPVY	ITCH,NEDD4	0.9129	More...
Q8IZQ1	WD repeat and FYVE domain-containing protein 3	ITCH	819:822	PPVY	ITCH,NEDD4	0.8291	More...
Q8WUM4	Programmed cell death 6-interacting protein	ITCH	834:837	PPVY	ITCH,NEDD4	0.9847	More...
Q92738	USP6 N-terminal-like protein	ITCH	635:638	PPVY	ITCH,NEDD4	0.9985	More...
Q96HB5	Coiled-coil domain-containing protein 120	ITCH	489:492	PPVY	ITCH,NEDD4	0.9291	More...
Q96I25	Splicing factor 45	ITCH	211:214	PPVY	ITCH,NEDD4	0.997	More...
Q96L91	E1A-binding protein p400	ITCH	2281:2284	PPVY	ITCH,NEDD4	0.9976	More...
Q96ST3	Paired amphipathic helix protein Sin3a	ITCH	38:41	PPVY	ITCH,NEDD4	0.5288	More...
Q9BRR9	Rho GTPase-activating protein 9	ITCH	188:191	PPVY	ITCH,NEDD4	0.9955	More...
Q9BYN7	Zinc finger protein 341	ITCH	255:258	PPVY	ITCH,NEDD4	0.9224	More...
Q9NR48	Histone-lysine N-methyltransferase ASH1L	ITCH	523:526	PPVY	ITCH,NEDD4	0.7929	More...
Q9UHG2	ProSAAS	ITCH	168:171	PPVY	ITCH,NEDD4	0.9983	More...
Q9UJ55	MAGE-like protein 2	ITCH	20:23	PPVY	ITCH,NEDD4	0.9909	More...
Q9UKI9	POU domain, class 2, transcription factor 3	ITCH	349:352	PPVY	ITCH,NEDD4	0.8894	More...
B8ZZ34	Protein shisa-8	ITCH	313:316	PPVY	ITCH,NEDD4	0.9544	More...
P59827	BPI fold-containing family B member 4	ITCH	72:75	PPVY	ITCH,NEDD4	0.993	More...
Q6PJG2	Mitotic deacetylase-associated SANT domain protein	ITCH	621:624	PPVY	ITCH,NEDD4	0.9954	More...
Q96DD7	Protein shisa-4	ITCH	176:179	PPVY	ITCH,NEDD4	0.8305	More...
Q9NZL6	Ral guanine nucleotide dissociation stimulator-like 1	ITCH	639:642	PPVY	ITCH,NEDD4	0.9944	More...
Q9P266	Junctional protein associated with coronary artery disease	ITCH	337:340	PPVY	ITCH,NEDD4	0.8881	More...
Q96ME7	Zinc finger protein 512	ITCH	147:150	PPVY	ITCH,NEDD4	0.8319	More...
Q9BXU3	Testis-expressed protein 13A	ITCH	371:374	PPVY	ITCH,NEDD4	0.6412	More...
Q9NWM3	CUE domain-containing protein 1	ITCH	128:131	PPVY	ITCH,NEDD4	0.9994	More...
A8MWL6	Putative synaptogyrin-2 like protein	ITCH	220:223	PPVY	ITCH,NEDD4	0.9995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPVY

Degron related mutations and impact score

Drug responses associated with USP6NL mutations

All proteins holding degron of PPVY