DegronMD

Uniprot ID: Q9NZL6

Source protein: Ral guanine nucleotide dissociation stimulator-like 1

Source gene: RGL1

Class: ITCH

Location: 639:642

E3 ligase: ITCH,NEDD4

DEGRON score: 0.9944

ASA_SCORE: 77.125

COIL: 0.8885

CONS_SCORE: 0.2573

DSS_SCORE: 0.395

HELIX: 0.0683

FCONS_SCORE: 0.8717

RIG_SCORE: 0.8062

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D633G	TCGA-06-5416	GBM	TCGA	PPVY	ITCH	0.1667
p.S648F	TCGA-3N-A9WC	SKCM	TCGA	PPVY	ITCH	0.1667
p.S636F	TCGA-55-1592	LUAD	TCGA	PPVY	ITCH	0.25
p.S636F	TCGA-ER-A19W	SKCM	TCGA	PPVY	ITCH	0.25
p.S636F	ACH-002508	Skin Cancer	CCLE	PPVY	ITCH	0.25
p.S647C	TCGA-77-A5GB	LUSC	TCGA	PPVY	ITCH	0.1944
p.G638R	TCGA-AL-7173	KIRP	TCGA	PPVY	ITCH	0.3056
p.G638R	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	PPVY	ITCH	0.3056
p.G638R	ACH-000980	Lung Cancer	CCLE	PPVY	ITCH	0.3056
p.G638R	NCI-H1155	lung	COSMIC	PPVY	ITCH	0.3056
p.D633N	TCGA-ER-A193	SKCM	TCGA	PPVY	ITCH	0.1667
p.P650S	TCGA-GN-A266	SKCM	TCGA	PPVY	ITCH	0.1111
p.H630Y	TCGA-GN-A4U7	SKCM	TCGA	PPVY	ITCH	0.0833
p.T631M	DO44440	HNSC	ICGC	PPVY	ITCH	0.1111
p.T631M	DO38192	STAD	ICGC	PPVY	ITCH	0.1111
p.N646K	DO44511	KIRP	ICGC	PPVY	ITCH	0.2222
p.S629L	DO26438	LUSC	ICGC	PPVY	ITCH	0.0556
p.S629L	SNU-81	large_intestine	COSMIC	PPVY	ITCH	0.0556
p.C650Y	DO51540	PACA	ICGC	PPVY	ITCH	0.1111
p.I651R	DO229582	PRAD	ICGC	PPVY	ITCH	0.0833
p.S632Y	DO229211	THCA	ICGC	PPVY	ITCH	0.1389
p.T636N	DO223286	UCEC	ICGC	PPVY	ITCH	0.25
p.P649H	ACH-000937	Leukemia	CCLE	PPVY	ITCH	0.1389
p.Q644K	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PPVY	ITCH	0.2778

Drug responses associated with RGL1 mutations

All proteins holding degron of PPVY

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NI15	Mesogenin-1	ITCH	152:155	PPVY	ITCH,NEDD4	0.9842	More...
O00358	Forkhead box protein E1	ITCH	209:212	PPVY	ITCH,NEDD4	0.6942	More...
O43760	Synaptogyrin-2	ITCH	221:224	PPVY	ITCH,NEDD4	0.9998	More...
O95696	Bromodomain-containing protein 1	ITCH	136:139	PPVY	ITCH,NEDD4	0.9995	More...
P05412	Transcription factor Jun	ITCH	167:170	PPVY	ITCH,NEDD4	0.9159	More...
P07202	Thyroid peroxidase	ITCH	178:181	PPVY	ITCH,NEDD4	0.6723	More...
P15311	Ezrin	ITCH	475:478	PPVY	ITCH,NEDD4	0.9955	More...
P16930	Fumarylacetoacetase	ITCH	187:190	PPVY	ITCH,NEDD4	0.9388	More...
P17275	Transcription factor JunB	ITCH	179:182	PPVY	ITCH,NEDD4	0.9876	More...
P19544	Wilms tumor protein	ITCH	197:200	PPVY	ITCH,NEDD4	0.9912	More...
P51817	cAMP-dependent protein kinase catalytic subunit PRKX	ITCH	41:44	PPVY	ITCH,NEDD4	0.9981	More...
P51841	Retinal guanylyl cyclase 2	ITCH	768:771	PPVY	ITCH,NEDD4	0.5364	More...
Q14738	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	ITCH	529:532	PPVY	ITCH,NEDD4	0.9915	More...
Q5TD94	Radial spoke head protein 4 homolog A	ITCH	663:666	PPVY	ITCH,NEDD4	0.999	More...
Q8IWI9	MAX gene-associated protein	ITCH	1388:1391	PPVY	ITCH,NEDD4	0.9681	More...
Q8IWZ3	Ankyrin repeat and KH domain-containing protein 1	ITCH	1039:1042	PPVY	ITCH,NEDD4	0.9027	More...
Q8IYH5	ZZ-type zinc finger-containing protein 3	ITCH	752:755	PPVY	ITCH,NEDD4	0.9129	More...
Q8IZQ1	WD repeat and FYVE domain-containing protein 3	ITCH	819:822	PPVY	ITCH,NEDD4	0.8291	More...
Q8WUM4	Programmed cell death 6-interacting protein	ITCH	834:837	PPVY	ITCH,NEDD4	0.9847	More...
Q92738	USP6 N-terminal-like protein	ITCH	635:638	PPVY	ITCH,NEDD4	0.9985	More...
Q96HB5	Coiled-coil domain-containing protein 120	ITCH	489:492	PPVY	ITCH,NEDD4	0.9291	More...
Q96I25	Splicing factor 45	ITCH	211:214	PPVY	ITCH,NEDD4	0.997	More...
Q96L91	E1A-binding protein p400	ITCH	2281:2284	PPVY	ITCH,NEDD4	0.9976	More...
Q96ST3	Paired amphipathic helix protein Sin3a	ITCH	38:41	PPVY	ITCH,NEDD4	0.5288	More...
Q9BRR9	Rho GTPase-activating protein 9	ITCH	188:191	PPVY	ITCH,NEDD4	0.9955	More...
Q9BYN7	Zinc finger protein 341	ITCH	255:258	PPVY	ITCH,NEDD4	0.9224	More...
Q9NR48	Histone-lysine N-methyltransferase ASH1L	ITCH	523:526	PPVY	ITCH,NEDD4	0.7929	More...
Q9UHG2	ProSAAS	ITCH	168:171	PPVY	ITCH,NEDD4	0.9983	More...
Q9UJ55	MAGE-like protein 2	ITCH	20:23	PPVY	ITCH,NEDD4	0.9909	More...
Q9UKI9	POU domain, class 2, transcription factor 3	ITCH	349:352	PPVY	ITCH,NEDD4	0.8894	More...
B8ZZ34	Protein shisa-8	ITCH	313:316	PPVY	ITCH,NEDD4	0.9544	More...
P59827	BPI fold-containing family B member 4	ITCH	72:75	PPVY	ITCH,NEDD4	0.993	More...
Q6PJG2	Mitotic deacetylase-associated SANT domain protein	ITCH	621:624	PPVY	ITCH,NEDD4	0.9954	More...
Q96DD7	Protein shisa-4	ITCH	176:179	PPVY	ITCH,NEDD4	0.8305	More...
Q9NZL6	Ral guanine nucleotide dissociation stimulator-like 1	ITCH	639:642	PPVY	ITCH,NEDD4	0.9944	More...
Q9P266	Junctional protein associated with coronary artery disease	ITCH	337:340	PPVY	ITCH,NEDD4	0.8881	More...
Q96ME7	Zinc finger protein 512	ITCH	147:150	PPVY	ITCH,NEDD4	0.8319	More...
Q9BXU3	Testis-expressed protein 13A	ITCH	371:374	PPVY	ITCH,NEDD4	0.6412	More...
Q9NWM3	CUE domain-containing protein 1	ITCH	128:131	PPVY	ITCH,NEDD4	0.9994	More...
A8MWL6	Putative synaptogyrin-2 like protein	ITCH	220:223	PPVY	ITCH,NEDD4	0.9995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPVY

Degron related mutations and impact score

Drug responses associated with RGL1 mutations

All proteins holding degron of PPVY