DegronMD - O95696(BRD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S131F	TCGA-29-1770	OV	TCGA	PPVY	ITCH	136:139	Mutation blocking phosphorylation signal	0.6389
p.S131F	DO31664	OV	ICGC	PPVY	ITCH	136:139	Mutation blocking phosphorylation signal	0.6389
p.N399Y	TCGA-36-2545	OV	TCGA	LNIYGD	LIG_APCC_ABBA_1	398:403	Mutation altering degron motif	0.5948
p.N399Y	DO28015	OV	ICGC	LNIYGD	LIG_APCC_ABBA_1	398:403	Mutation altering degron motif	0.5948
p.R427K	TCGA-3N-A9WC	SKCM	TCGA	VRSTS	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.25
p.R427K	DO51234	SKCM	ICGC	VRSTS	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.25
p.E405K	TCGA-B5-A0JY	UCEC	TCGA	LNIYGD	LIG_APCC_ABBA_1	398:403	Mutation rewiring degron network	0.2778
p.E405K	TCGA-BS-A0UF	UCEC	TCGA	LNIYGD	LIG_APCC_ABBA_1	398:403	Mutation rewiring degron network	0.2778
p.E405K	DO233767	GACA	ICGC	LNIYGD	LIG_APCC_ABBA_1	398:403	Mutation rewiring degron network	0.2778
p.E405K	DO229055	LICA	ICGC	LNIYGD	LIG_APCC_ABBA_1	398:403	Mutation rewiring degron network	0.2778
p.E405K	DO43041	UCEC	ICGC	LNIYGD	LIG_APCC_ABBA_1	398:403	Mutation rewiring degron network	0.2778
p.E405K	DO41488	UCEC	ICGC	LNIYGD	LIG_APCC_ABBA_1	398:403	Mutation rewiring degron network	0.2778
p.S422Y	TCGA-BR-A4CS	STAD	TCGA	VRSTS	DEG_SPOP_SBC_1	420:424	Mutation altering degron motif	0.8231
p.S422Y	DO47965	STAD	ICGC	VRSTS	DEG_SPOP_SBC_1	420:424	Mutation altering degron motif	0.8231
p.A147T	TCGA-CD-A4MI	STAD	TCGA	PPVY	ITCH	136:139	Mutation rewiring degron network	0.1111
p.A147T	DO47717	STAD	ICGC	PPVY	ITCH	136:139	Mutation rewiring degron network	0.1111
p.T389M	TCGA-CN-6012	HNSC	TCGA	LNIYGD	LIG_APCC_ABBA_1	398:403	Mutation rewiring degron network	0.0833
p.T389M	DO15743	HNSC	ICGC	LNIYGD	LIG_APCC_ABBA_1	398:403	Mutation rewiring degron network	0.0833
p.R427S	TCGA-D1-A103	UCEC	TCGA	VRSTS	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.25
p.R427S	DO42312	UCEC	ICGC	VRSTS	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.25
p.P129L	TCGA-DA-A1HY	SKCM	TCGA	PPVY	ITCH	136:139	Mutation rewiring degron network	0.1389
p.P129L	DO37409	SKCM	ICGC	PPVY	ITCH	136:139	Mutation rewiring degron network	0.1389
p.S415N	TCGA-FS-A1ZK	SKCM	TCGA	VRSTS	DEG_SPOP_SBC_1	420:424	Mutation blocking phosphorylation signal	0.6389
p.S415N	DO37474	SKCM	ICGC	VRSTS	DEG_SPOP_SBC_1	420:424	Mutation blocking phosphorylation signal	0.6389
p.V410I	DO227549	COCA	ICGC	VRSTS	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.0556
p.V410I	DO227549	COCA	ICGC	LNIYGD	LIG_APCC_ABBA_1	398:403	Mutation rewiring degron network	0.1389
p.D403G	DO234285	ESAD	ICGC	LNIYGD	LIG_APCC_ABBA_1	398:403	Mutation altering degron motif	0.7198
p.D403G	SIDM00150	Colorectal Carcinoma	GDSC	LNIYGD	LIG_APCC_ABBA_1	398:403	Mutation altering degron motif	0.7198
p.D403G	SIDM01766	Chondrosarcoma	GDSC	LNIYGD	LIG_APCC_ABBA_1	398:403	Mutation altering degron motif	0.7198
p.G402R	DO233784	GACA	ICGC	LNIYGD	LIG_APCC_ABBA_1	398:403	Mutation altering degron motif	0.6457
p.A430E	DO228985	LICA	ICGC	VRSTS	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.1667
p.H388N	DO229018	LICA	ICGC	LNIYGD	LIG_APCC_ABBA_1	398:403	Mutation rewiring degron network	0.0556
p.E414K	DO222843	MELA	ICGC	VRSTS	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.1667
p.L398R	DO52152	PAEN	ICGC	LNIYGD	LIG_APCC_ABBA_1	398:403	Mutation altering degron motif	0.8428
p.V404A	SIDM00878	Breast Carcinoma	GDSC	LNIYGD	LIG_APCC_ABBA_1	398:403	Mutation rewiring degron network	0.3056
p.V404A	ACH-000930	Breast Cancer	CCLE	LNIYGD	LIG_APCC_ABBA_1	398:403	Mutation rewiring degron network	0.3056
p.V404A	HCC1569	breast	COSMIC	LNIYGD	LIG_APCC_ABBA_1	398:403	Mutation rewiring degron network	0.3056
p.V426A	ACH-001416	Bladder Cancer	CCLE	VRSTS	DEG_SPOP_SBC_1	420:424	Mutation rewiring degron network	0.2778

Kaplan plot for BRD1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BRD1

UniProt ID: O95696

Entrez ID: 23774

Protein name: Bromodomain-containing protein 1 (BR140-like protein) (Bromodomain and PHD finger-containing protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BRD1 in