DegronMD

Uniprot ID: O95696

Source protein: Bromodomain-containing protein 1

Source gene: BRD1

Class: DEG_SPOP_SBC_1

Location: 420:424

E3 ligase: SPOP

DEGRON score: 0.9741

ASA_SCORE: 96.88

COIL: 0.5188

CONS_SCORE: 0.3758

DSS_SCORE: 0.5127

HELIX: 0.4708

FCONS_SCORE: 1.0496

RIG_SCORE: 0.7606

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R427K	TCGA-3N-A9WC	SKCM	TCGA	VRSTS	DEG_SPOP_SBC_1	0.25
p.R427K	DO51234	SKCM	ICGC	VRSTS	DEG_SPOP_SBC_1	0.25
p.S422Y	TCGA-BR-A4CS	STAD	TCGA	VRSTS	DEG_SPOP_SBC_1	0.8231
p.S422Y	DO47965	STAD	ICGC	VRSTS	DEG_SPOP_SBC_1	0.8231
p.R427S	TCGA-D1-A103	UCEC	TCGA	VRSTS	DEG_SPOP_SBC_1	0.25
p.R427S	DO42312	UCEC	ICGC	VRSTS	DEG_SPOP_SBC_1	0.25
p.S415N	TCGA-FS-A1ZK	SKCM	TCGA	VRSTS	DEG_SPOP_SBC_1	0.6389
p.S415N	DO37474	SKCM	ICGC	VRSTS	DEG_SPOP_SBC_1	0.6389
p.V410I	DO227549	COCA	ICGC	VRSTS	DEG_SPOP_SBC_1	0.0556
p.A430E	DO228985	LICA	ICGC	VRSTS	DEG_SPOP_SBC_1	0.1667
p.E414K	DO222843	MELA	ICGC	VRSTS	DEG_SPOP_SBC_1	0.1667
p.V426A	ACH-001416	Bladder Cancer	CCLE	VRSTS	DEG_SPOP_SBC_1	0.2778

Drug responses associated with BRD1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM01045	UCEC\|endometrium	p.D993fs*1 (No)	GDSC	OF-1	24.595
SIDM00951	LAML\|acute_myeloid_leukaemia	p.S1026F (No)	GDSC	OF-1	32.483
SIDM00951	LAML\|acute_myeloid_leukaemia	p.R550H (No)	GDSC	OF-1	32.483
SIDM00951	LAML\|acute_myeloid_leukaemia	p.C218* (No)	GDSC	OF-1	32.483
SIDM00145	ALL\|lymphoblastic_leukemia	p.G806R (No)	GDSC	OF-1	1.62
SIDM00145	ALL\|lymphoblastic_leukemia	p.D151N (No)	GDSC	OF-1	1.62
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.Q501K (No)	GDSC	OF-1	37.382
SIDM00683	PRAD\|prostate	p.M2T (No)	GDSC	OF-1	125.56
SIDM00334	UCEC\|endometrium	p.R468Q (No)	GDSC	OF-1	4.8628
SIDM00461	LAML\|acute_myeloid_leukaemia	p.A874S (No)	GDSC	OF-1	29.662
SIDM00461	LAML\|acute_myeloid_leukaemia	p.R856L (No)	GDSC	OF-1	29.662
SIDM00461	LAML\|acute_myeloid_leukaemia	p.R850H (No)	GDSC	OF-1	29.662
SIDM00461	LAML\|acute_myeloid_leukaemia	p.A840T (No)	GDSC	OF-1	29.662
SIDM00461	LAML\|acute_myeloid_leukaemia	p.N821H (No)	GDSC	OF-1	29.662
SIDM00461	LAML\|acute_myeloid_leukaemia	p.K816N (No)	GDSC	OF-1	29.662
SIDM00461	LAML\|acute_myeloid_leukaemia	p.K789N (No)	GDSC	OF-1	29.662
SIDM00461	LAML\|acute_myeloid_leukaemia	p.D788A (No)	GDSC	OF-1	29.662
SIDM00527	COREAD\|large_intestine	p.A867V (No)	GDSC	OF-1	50.652
SIDM00669	PAAD\|pancreas	p.G806R (No)	GDSC	OF-1	45.845
SIDM00174	HNSC\|head_and_neck	p.V178A (No)	GDSC	OF-1	60.031
SIDM00537	COREAD\|large_intestine	p.K432fs*26 (Yes)	GDSC	OF-1	51.217
SIDM00971	BRCA\|breast	p.R1045H (No)	GDSC	OF-1	112.72
SIDM00704	SCLC\|lung_small_cell_carcinoma	p.E976Q (No)	GDSC	OF-1	112.63
SIDM01088	UNCLASSIFIED\|endometrium	p.A383T (No)	GDSC	OF-1	9.243
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.R91C (No)	GDSC	OF-1	44.461
SIDM01090	COREAD\|large_intestine	p.C217R (No)	GDSC	OF-1	53.326
SIDM00434	MM\|myeloma	p.R9Q (No)	GDSC	OF-1	17.906
SIDM00431	ALL\|lymphoblastic_T_cell_leukaemia	p.R468Q (No)	GDSC	OF-1	18.418
SIDM00602	STAD\|stomach	p.R880C (No)	GDSC	OF-1	17.272
SIDM01122	UNCLASSIFIED\|lung_NSCLC_large_cell	p.S17P (No)	GDSC	OF-1	64.916
SIDM00946	ALL\|T_cell_leukemia	p.A874S (No)	GDSC	OF-1	19.143
SIDM00946	ALL\|T_cell_leukemia	p.R856L (No)	GDSC	OF-1	19.143
SIDM00946	ALL\|T_cell_leukemia	p.R850H (No)	GDSC	OF-1	19.143
SIDM00946	ALL\|T_cell_leukemia	p.A840T (No)	GDSC	OF-1	19.143
SIDM00946	ALL\|T_cell_leukemia	p.N821H (No)	GDSC	OF-1	19.143
SIDM00946	ALL\|T_cell_leukemia	p.K816N (No)	GDSC	OF-1	19.143
SIDM00946	ALL\|T_cell_leukemia	p.K789N (No)	GDSC	OF-1	19.143
SIDM00946	ALL\|T_cell_leukemia	p.D788A (No)	GDSC	OF-1	19.143
SIDM00249	ESCA\|oesophagus	p.S113L (No)	GDSC	OF-1	228.74
SIDM00590	HNSC\|head_and_neck	p.L633V (No)	GDSC	OF-1	22.51
SIDM00217	COREAD\|large_intestine	p.R974H (No)	GDSC	OF-1	46.7
SIDM00217	COREAD\|large_intestine	p.P566L (No)	GDSC	OF-1	46.7
SIDM00217	COREAD\|large_intestine	p.R536H (No)	GDSC	OF-1	46.7
SIDM00217	COREAD\|large_intestine	p.A442T (No)	GDSC	OF-1	46.7
SIDM00280	UNCLASSIFIED\|stomach	p.T1051S (No)	GDSC	OF-1	100.12
SIDM00933	BRCA\|breast	p.R850H (No)	GDSC	OF-1	35.829
SIDM00839	COREAD\|large_intestine	p.V241M (No)	GDSC	OF-1	96.444
SIDM00216	COREAD\|large_intestine	p.V1046I (No)	GDSC	OF-1	41.481
SIDM00216	COREAD\|large_intestine	p.V1032M (No)	GDSC	OF-1	41.481
SIDM00231	KIRC\|kidney	p.P691L (No)	GDSC	OF-1	110.29
SIDM00282	COREAD\|large_intestine	p.M362V (No)	GDSC	OF-1	42.633
SIDM00282	COREAD\|large_intestine	p.V248A (No)	GDSC	OF-1	42.633
SIDM00282	COREAD\|large_intestine	p.M236T (No)	GDSC	OF-1	42.633
SIDM00150	COREAD\|large_intestine	p.P606S (No)	GDSC	OF-1	206.7
SIDM00766	SCLC\|lung_small_cell_carcinoma	p.L65V (No)	GDSC	OF-1	78.694
SIDM00660	COREAD\|large_intestine	p.R847Q (No)	GDSC	OF-1	25.498
SIDM01000	SKCM\|melanoma	p.S858F (No)	GDSC	OF-1	193.21
SIDM01100	NB\|neuroblastoma	p.R504* (No)	GDSC	OF-1	85.001
SIDM00783	COREAD\|large_intestine	p.R880H (No)	GDSC	OF-1	25.54
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.R913K (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A909V (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A404E (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.F898Y (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A874S (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.R856L (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.R850H (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A840T (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.N821H (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.K816N (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.E626D (No)	GDSC	OF-1	25.503
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.E626A (No)	GDSC	OF-1	25.503
SIDM00878	BRCA\|breast	p.K432fs*26 (Yes)	GDSC	OF-1	161.05
SIDM00487	COREAD\|large_intestine	p.D630G (No)	GDSC	OF-1	80.95
SIDM00487	COREAD\|large_intestine	p.V335M (No)	GDSC	OF-1	80.95
SIDM00282	COREAD\|large_intestine	p.L492fs*21 (No)	GDSC	OF-1	42.633
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.A871V (No)	GDSC	OF-1	43.479
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.M1006I (No)	GDSC	OF-1	134.7
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.T565A (No)	GDSC	OF-1	134.7
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.R1029W (No)	GDSC	OF-1	37.771
SIDM00537	COREAD\|large_intestine	p.A1039T (No)	GDSC	OF-1	51.217
SIDM00878	BRCA\|breast	p.V404A (No)	GDSC	OF-1	161.05
SIDM00579	NB\|neuroblastoma	p.R9Q (No)	GDSC	OF-1	56.991
SIDM00796	UNCLASSIFIED\|head_and_neck	p.Q463E (No)	GDSC	OF-1	44.627
SIDM00118	COREAD\|large_intestine	p.T32A (No)	GDSC	OF-1	62.526
SIDM00860	HNSC\|head_and_neck	p.V1046A (No)	GDSC	OF-1	175.57
SIDM01144	STAD\|stomach	p.E102K (No)	GDSC	OF-1	27.071

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60941	Dystrobrevin beta	DEG_SPOP_SBC_1	548:552	VRSTS	SPOP	0.7802	More...
O95696	Bromodomain-containing protein 1	DEG_SPOP_SBC_1	420:424	VRSTS	SPOP	0.9741	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	1748:1752	VRSTS	SPOP	0.8843	More...
Q7Z6J6	FERM domain-containing protein 5	DEG_SPOP_SBC_1	392:396	VRSTS	SPOP	0.8657	More...
Q9P202	Whirlin	DEG_SPOP_SBC_1	569:573	VRSTS	SPOP	0.9813	More...
Q5VZP5	Serine/threonine/tyrosine-interacting-like protein 2	DEG_SPOP_SBC_1	1001:1005	VRSTS	SPOP	0.8835	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VRSTS

Degron related mutations and impact score

Drug responses associated with BRD1 mutations

All proteins holding degron of VRSTS