DegronMD - Q7Z6J6(FRMD5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R393C	TCGA-A5-A1OF	UCEC	TCGA	VRSTS	DEG_SPOP_SBC_1	392:396	Mutation altering degron motif	0.719
p.R393C	SIDM00789	Colorectal Carcinoma	GDSC	VRSTS	DEG_SPOP_SBC_1	392:396	Mutation altering degron motif	0.719
p.R393C	ACH-000997	Colon/Colorectal Cancer	CCLE	VRSTS	DEG_SPOP_SBC_1	392:396	Mutation altering degron motif	0.719
p.R393C	ACH-001061	Colon/Colorectal Cancer	CCLE	VRSTS	DEG_SPOP_SBC_1	392:396	Mutation altering degron motif	0.719
p.R393C	HCT-15	large intestine	COSMIC	VRSTS	DEG_SPOP_SBC_1	392:396	Mutation altering degron motif	0.719
p.S389Y	TCGA-A8-A08G	BRCA	TCGA	VRSTS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.25
p.R384W	TCGA-AM-5821	COAD	TCGA	VRSTS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.1111
p.P432T	TCGA-AP-A1DV	UCEC	TCGA	VLPTPVAE	DEG_SCF_FBW7_2	430:437	Mutation altering degron motif	0.5919
p.P434L	TCGA-DA-A3F3	SKCM	TCGA	VLPTPVAE	DEG_SCF_FBW7_2	430:437	Mutation altering degron motif	0.7582
p.R393H	TCGA-EA-A3HS	CESC	TCGA	VRSTS	DEG_SPOP_SBC_1	392:396	Mutation altering degron motif	0.7133
p.R393H	SIDM01001	Breast Carcinoma	GDSC	VRSTS	DEG_SPOP_SBC_1	392:396	Mutation altering degron motif	0.7133
p.R393H	ACH-000258	Breast Cancer	CCLE	VRSTS	DEG_SPOP_SBC_1	392:396	Mutation altering degron motif	0.7133
p.R393H	DU-4475	breast	COSMIC	VRSTS	DEG_SPOP_SBC_1	392:396	Mutation altering degron motif	0.7133
p.E422K	TCGA-EO-A3AV	UCEC	TCGA	VLPTPVAE	DEG_SCF_FBW7_2	430:437	Mutation rewiring degron network	0.1111
p.E422K	TCGA-XF-AAMZ	BLCA	TCGA	VLPTPVAE	DEG_SCF_FBW7_2	430:437	Mutation rewiring degron network	0.1111
p.E441K	TCGA-UY-A78K	BLCA	TCGA	VLPTPVAE	DEG_SCF_FBW7_2	430:437	Mutation rewiring degron network	0.2222
p.G398R	TCGA-YL-A8SJ	PRAD	TCGA	VRSTS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.2778
p.E397K	DO6269	CESC	ICGC	VRSTS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.3056
p.E397K	DO51254	SKCM	ICGC	VRSTS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.3056
p.A400E	DO229046	LICA	ICGC	VRSTS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.2222
p.E396K	DO36467	READ	ICGC	VRSTS	DEG_SPOP_SBC_1	392:396	Mutation altering degron motif	0.7022
p.P432S	SIDM00609	Kidney Carcinoma	GDSC	VLPTPVAE	DEG_SCF_FBW7_2	430:437	Mutation altering degron motif	0.5641
p.P432S	SIDM01217	Other Blood Cancers	GDSC	VLPTPVAE	DEG_SCF_FBW7_2	430:437	Mutation altering degron motif	0.5641
p.P432S	ACH-000250	Kidney Cancer	CCLE	VLPTPVAE	DEG_SCF_FBW7_2	430:437	Mutation altering degron motif	0.5641
p.P432S	ACH-002276	Leukemia	CCLE	VLPTPVAE	DEG_SCF_FBW7_2	430:437	Mutation altering degron motif	0.5641
p.P432S	KMRC-20	kidney	COSMIC	VLPTPVAE	DEG_SCF_FBW7_2	430:437	Mutation altering degron motif	0.5641
p.P432S	MY-M12	haematopoietic and lymphoid tissue	COSMIC	VLPTPVAE	DEG_SCF_FBW7_2	430:437	Mutation altering degron motif	0.5641
p.T395S	SIDM01519	Head and Neck Carcinoma	GDSC	VRSTS	DEG_SPOP_SBC_1	392:396	Mutation altering degron motif	0.6005
p.D399A	ACH-000448	Lung Cancer	CCLE	VRSTS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.25
p.D399A	NCI-H1666	lung	COSMIC	VRSTS	DEG_SPOP_SBC_1	392:396	Mutation rewiring degron network	0.25

Kaplan plot for FRMD5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FRMD5

UniProt ID: Q7Z6J6

Entrez ID: 84978

Protein name: FERM domain-containing protein 5

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FRMD5 in