DegronMD

Uniprot ID: Q7Z6J6

Source protein: FERM domain-containing protein 5

Source gene: FRMD5

Class: DEG_SPOP_SBC_1

Location: 392:396

E3 ligase: SPOP

DEGRON score: 0.8657

ASA_SCORE: 90.8

COIL: 0.8328

CONS_SCORE: 0.348

DSS_SCORE: 0.586

HELIX: 0.0402

FCONS_SCORE: 1.0984

RIG_SCORE: 0.5979

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R393C	TCGA-A5-A1OF	UCEC	TCGA	VRSTS	DEG_SPOP_SBC_1	0.719
p.R393C	SIDM00789	Colorectal Carcinoma	GDSC	VRSTS	DEG_SPOP_SBC_1	0.719
p.R393C	ACH-000997	Colon/Colorectal Cancer	CCLE	VRSTS	DEG_SPOP_SBC_1	0.719
p.R393C	ACH-001061	Colon/Colorectal Cancer	CCLE	VRSTS	DEG_SPOP_SBC_1	0.719
p.R393C	HCT-15	large_intestine	COSMIC	VRSTS	DEG_SPOP_SBC_1	0.719
p.S389Y	TCGA-A8-A08G	BRCA	TCGA	VRSTS	DEG_SPOP_SBC_1	0.25
p.R384W	TCGA-AM-5821	COAD	TCGA	VRSTS	DEG_SPOP_SBC_1	0.1111
p.R393H	TCGA-EA-A3HS	CESC	TCGA	VRSTS	DEG_SPOP_SBC_1	0.7133
p.R393H	SIDM01001	Breast Carcinoma	GDSC	VRSTS	DEG_SPOP_SBC_1	0.7133
p.R393H	ACH-000258	Breast Cancer	CCLE	VRSTS	DEG_SPOP_SBC_1	0.7133
p.R393H	DU-4475	breast	COSMIC	VRSTS	DEG_SPOP_SBC_1	0.7133
p.G398R	TCGA-YL-A8SJ	PRAD	TCGA	VRSTS	DEG_SPOP_SBC_1	0.2778
p.E397K	DO6269	CESC	ICGC	VRSTS	DEG_SPOP_SBC_1	0.3056
p.E397K	DO51254	SKCM	ICGC	VRSTS	DEG_SPOP_SBC_1	0.3056
p.A400E	DO229046	LICA	ICGC	VRSTS	DEG_SPOP_SBC_1	0.2222
p.E396K	DO36467	READ	ICGC	VRSTS	DEG_SPOP_SBC_1	0.7022
p.T395S	SIDM01519	Head and Neck Carcinoma	GDSC	VRSTS	DEG_SPOP_SBC_1	0.6005
p.D399A	ACH-000448	Lung Cancer	CCLE	VRSTS	DEG_SPOP_SBC_1	0.25
p.D399A	NCI-H1666	lung	COSMIC	VRSTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60941	Dystrobrevin beta	DEG_SPOP_SBC_1	548:552	VRSTS	SPOP	0.7802	More...
O95696	Bromodomain-containing protein 1	DEG_SPOP_SBC_1	420:424	VRSTS	SPOP	0.9741	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	1748:1752	VRSTS	SPOP	0.8843	More...
Q7Z6J6	FERM domain-containing protein 5	DEG_SPOP_SBC_1	392:396	VRSTS	SPOP	0.8657	More...
Q9P202	Whirlin	DEG_SPOP_SBC_1	569:573	VRSTS	SPOP	0.9813	More...
Q5VZP5	Serine/threonine/tyrosine-interacting-like protein 2	DEG_SPOP_SBC_1	1001:1005	VRSTS	SPOP	0.8835	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons