DegronMD - P12270(TPR)

FUNCTION: Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:22253824 and PubMed:11952838). Plays also a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases. {ECO:0000269|PubMed:11952838, ECO:0000269|PubMed:15654337, ECO:0000269|PubMed:17897941, ECO:0000269|PubMed:18794356, ECO:0000269|PubMed:18981471, ECO:0000269|PubMed:19273613, ECO:0000269|PubMed:20133940, ECO:0000269|PubMed:20407419, ECO:0000269|PubMed:21613532, ECO:0000269|PubMed:22253824, ECO:0000269|PubMed:9864356}. View more >>

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GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L2300I	TCGA-06-5416	GBM	TCGA	PPSSS	DEG_SPOP_SBC_1	2307:2311	Mutation rewiring degron network	0.1389
p.L2300I	DO222874	COCA	ICGC	PPSSS	DEG_SPOP_SBC_1	2307:2311	Mutation rewiring degron network	0.1389
p.L2300I	DO10880	GBM	ICGC	PPSSS	DEG_SPOP_SBC_1	2307:2311	Mutation rewiring degron network	0.1389
p.S2240C	TCGA-17-Z062	LUAD	TCGA	VTTST	DEG_SPOP_SBC_1	2244:2248	Mutation rewiring degron network	0.2222
p.M1686T	TCGA-34-5236	LUSC	TCGA	IKPTPVVS	DEG_SCF_FBW7_1	1669:1676	Mutation rewiring degron network	0.0556
p.M1686T	DO26778	LUSC	ICGC	IKPTPVVS	DEG_SCF_FBW7_1	1669:1676	Mutation rewiring degron network	0.0556
p.D2232Y	TCGA-44-7670	LUAD	TCGA	VTVFTE	LIG_APCC_ABBA_1	2222:2227	Mutation rewiring degron network	0.1944
p.D2232Y	DO23555	LUAD	ICGC	VTVFTE	LIG_APCC_ABBA_1	2222:2227	Mutation rewiring degron network	0.1944
p.S2316G	TCGA-49-AAR4	LUAD	TCGA	VDTSS	DEG_SPOP_SBC_1	2313:2317	Mutation altering degron motif	0.6993
p.S2316G	DO218920	LUAD	ICGC	VDTSS	DEG_SPOP_SBC_1	2313:2317	Mutation altering degron motif	0.6993
p.P2320S	TCGA-49-AAR9	LUAD	TCGA	PPSSS	DEG_SPOP_SBC_1	2307:2311	Mutation rewiring degron network	0.0833
p.P2320S	TCGA-49-AAR9	LUAD	TCGA	VDTSS	DEG_SPOP_SBC_1	2313:2317	Mutation rewiring degron network	0.25
p.P2320S	DO218921	LUAD	ICGC	PPSSS	DEG_SPOP_SBC_1	2307:2311	Mutation rewiring degron network	0.0833
p.P2320S	DO218921	LUAD	ICGC	VDTSS	DEG_SPOP_SBC_1	2313:2317	Mutation rewiring degron network	0.25
p.Q2319H	TCGA-49-AAR9	LUAD	TCGA	PPSSS	DEG_SPOP_SBC_1	2307:2311	Mutation rewiring degron network	0.1111
p.Q2319H	TCGA-49-AAR9	LUAD	TCGA	VDTSS	DEG_SPOP_SBC_1	2313:2317	Mutation rewiring degron network	0.2778
p.Q2319H	DO218921	LUAD	ICGC	PPSSS	DEG_SPOP_SBC_1	2307:2311	Mutation rewiring degron network	0.1111
p.Q2319H	DO218921	LUAD	ICGC	VDTSS	DEG_SPOP_SBC_1	2313:2317	Mutation rewiring degron network	0.2778
p.E1807Q	TCGA-50-5055	LUAD	TCGA	PSTST	DEG_SPOP_SBC_1	1809:1813	Mutation rewiring degron network	0.2778
p.E1807Q	DO25454	LUAD	ICGC	PSTST	DEG_SPOP_SBC_1	1809:1813	Mutation rewiring degron network	0.2778
p.G2183S	TCGA-76-6191	GBM	TCGA	PQTSS	DEG_SPOP_SBC_1	2173:2177	Mutation rewiring degron network	0.1667
p.E2170K	TCGA-77-7140	LUSC	TCGA	PQTSS	DEG_SPOP_SBC_1	2173:2177	Mutation rewiring degron network	0.25
p.E2170K	DO26455	LUSC	ICGC	PQTSS	DEG_SPOP_SBC_1	2173:2177	Mutation rewiring degron network	0.25
p.P1709R	TCGA-85-7697	LUSC	TCGA	PTTTPTAT	DEG_SCF_FBW7_1	1709:1716	Mutation altering degron motif	0.7512
p.P1709R	DO27053	LUSC	ICGC	PTTTPTAT	DEG_SCF_FBW7_1	1709:1716	Mutation altering degron motif	0.7512
p.L1855V	TCGA-92-8065	LUSC	TCGA	VTPVGT	DEG_SCF_FBW7_1	1862:1867	Mutation rewiring degron network	0.1389
p.L1855V	DO27074	LUSC	ICGC	VTPVGT	DEG_SCF_FBW7_1	1862:1867	Mutation rewiring degron network	0.1389
p.L2251V	TCGA-A5-A0G2	UCEC	TCGA	VTTST	DEG_SPOP_SBC_1	2244:2248	Mutation rewiring degron network	0.25
p.L2251V	DO41235	UCEC	ICGC	VTTST	DEG_SPOP_SBC_1	2244:2248	Mutation rewiring degron network	0.25
p.V2222M	TCGA-A8-A06R	BRCA	TCGA	VTVFTE	LIG_APCC_ABBA_1	2222:2227	Mutation altering degron motif	0.6097
p.V2222M	DO5165	BRCA	ICGC	VTVFTE	LIG_APCC_ABBA_1	2222:2227	Mutation altering degron motif	0.6097
p.S1820L	TCGA-AN-A046	BRCA	TCGA	VSATPSSS	DEG_SCF_FBW7_1	1819:1826	Mutation altering degron motif	0.6556
p.S1820L	DO1285	BRCA	ICGC	VSATPSSS	DEG_SCF_FBW7_1	1819:1826	Mutation altering degron motif	0.6556
p.S1820L	SIDM01611	Endometrial Carcinoma	GDSC	VSATPSSS	DEG_SCF_FBW7_1	1819:1826	Mutation altering degron motif	0.6556
p.S1820L	ACH-000996	Endometrial/Uterine Cancer	CCLE	VSATPSSS	DEG_SCF_FBW7_1	1819:1826	Mutation altering degron motif	0.6556
p.R1749C	TCGA-AP-A0LM	UCEC	TCGA	VRSTS	DEG_SPOP_SBC_1	1748:1752	Mutation altering degron motif	0.719
p.R1749C	TCGA-AP-A1DV	UCEC	TCGA	VRSTS	DEG_SPOP_SBC_1	1748:1752	Mutation altering degron motif	0.719
p.R1749C	TCGA-D1-A17Q	UCEC	TCGA	VRSTS	DEG_SPOP_SBC_1	1748:1752	Mutation altering degron motif	0.719
p.R1749C	TCGA-D3-A8GM	SKCM	TCGA	VRSTS	DEG_SPOP_SBC_1	1748:1752	Mutation altering degron motif	0.719
p.R1749C	DO50288	SKCM	ICGC	VRSTS	DEG_SPOP_SBC_1	1748:1752	Mutation altering degron motif	0.719
p.R1749C	DO43306	UCEC	ICGC	VRSTS	DEG_SPOP_SBC_1	1748:1752	Mutation altering degron motif	0.719
p.R1749C	DO43186	UCEC	ICGC	VRSTS	DEG_SPOP_SBC_1	1748:1752	Mutation altering degron motif	0.719
p.R1749C	DO41903	UCEC	ICGC	VRSTS	DEG_SPOP_SBC_1	1748:1752	Mutation altering degron motif	0.719
p.R1749C	SIDM01043	Other Sarcomas	GDSC	VRSTS	DEG_SPOP_SBC_1	1748:1752	Mutation altering degron motif	0.719
p.R1749C	ACH-000913	Endometrial/Uterine Cancer	CCLE	VRSTS	DEG_SPOP_SBC_1	1748:1752	Mutation altering degron motif	0.719
p.R1749C	ESS-1	endometrium	COSMIC	VRSTS	DEG_SPOP_SBC_1	1748:1752	Mutation altering degron motif	0.719
p.V1815A	TCGA-AP-A0LP	UCEC	TCGA	VSATPSSS	DEG_SCF_FBW7_1	1819:1826	Mutation rewiring degron network	0.2222
p.V1815A	TCGA-AP-A0LP	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	1809:1813	Mutation rewiring degron network	0.2778
p.V1815A	DO43146	UCEC	ICGC	VSATPSSS	DEG_SCF_FBW7_1	1819:1826	Mutation rewiring degron network	0.2222
p.V1815A	DO43146	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	1809:1813	Mutation rewiring degron network	0.2778
p.P1809S	TCGA-AX-A0J1	UCEC	TCGA	PSTST	DEG_SPOP_SBC_1	1809:1813	Mutation altering degron motif	0.6752
p.P1809S	DO41199	UCEC	ICGC	PSTST	DEG_SPOP_SBC_1	1809:1813	Mutation altering degron motif	0.6752
p.T1710N	TCGA-B5-A11E	UCEC	TCGA	PTTTPTAT	DEG_SCF_FBW7_1	1709:1716	Mutation altering degron motif	0.5944
p.T1710N	DO41644	UCEC	ICGC	PTTTPTAT	DEG_SCF_FBW7_1	1709:1716	Mutation altering degron motif	0.5944
p.T2229A	TCGA-BR-6452	STAD	TCGA	VTVFTE	LIG_APCC_ABBA_1	2222:2227	Mutation rewiring degron network	0.2778
p.T2229A	DO38404	STAD	ICGC	VTVFTE	LIG_APCC_ABBA_1	2222:2227	Mutation rewiring degron network	0.2778
p.R1808W	TCGA-BR-6452	STAD	TCGA	PSTST	DEG_SPOP_SBC_1	1809:1813	Mutation rewiring degron network	0.3056
p.R1808W	DO38404	STAD	ICGC	PSTST	DEG_SPOP_SBC_1	1809:1813	Mutation rewiring degron network	0.3056
p.E1724K	TCGA-BT-A42F	BLCA	TCGA	PTTTPTAT	DEG_SCF_FBW7_1	1709:1716	Mutation rewiring degron network	0.1111
p.E1724K	TCGA-BT-A42F	BLCA	TCGA	TPTATVMPT	DEG_SIAH_1	1712:1720	Mutation rewiring degron network	0.2222
p.E1724K	DO49726	BLCA	ICGC	PTTTPTAT	DEG_SCF_FBW7_1	1709:1716	Mutation rewiring degron network	0.1111
p.E1724K	DO49726	BLCA	ICGC	TPTATVMPT	DEG_SIAH_1	1712:1720	Mutation rewiring degron network	0.2222
p.T1710S	TCGA-CJ-5679	KIRC	TCGA	PTTTPTAT	DEG_SCF_FBW7_1	1709:1716	Mutation altering degron motif	0.6005
p.T1710S	DO18184	KIRC	ICGC	PTTTPTAT	DEG_SCF_FBW7_1	1709:1716	Mutation altering degron motif	0.6005
p.S2316T	TCGA-CM-5861	COAD	TCGA	VDTSS	DEG_SPOP_SBC_1	2313:2317	Mutation altering degron motif	0.6005
p.S2316T	DO7918	COAD	ICGC	VDTSS	DEG_SPOP_SBC_1	2313:2317	Mutation altering degron motif	0.6005
p.S1804L	TCGA-CN-A63W	HNSC	TCGA	PSTST	DEG_SPOP_SBC_1	1809:1813	Mutation rewiring degron network	0.1944
p.S1804L	DO49031	HNSC	ICGC	PSTST	DEG_SPOP_SBC_1	1809:1813	Mutation rewiring degron network	0.1944
p.R1830H	TCGA-D1-A167	UCEC	TCGA	VSATPSSS	DEG_SCF_FBW7_1	1819:1826	Mutation rewiring degron network	0.2222
p.R1830H	DO40978	UCEC	ICGC	VSATPSSS	DEG_SCF_FBW7_1	1819:1826	Mutation rewiring degron network	0.2222
p.S1760Y	TCGA-DF-A2KU	UCEC	TCGA	VRSTS	DEG_SPOP_SBC_1	1748:1752	Mutation rewiring degron network	0.1111
p.S1760Y	DO223286	UCEC	ICGC	VRSTS	DEG_SPOP_SBC_1	1748:1752	Mutation rewiring degron network	0.1111
p.P1753S	TCGA-DF-A2KU	UCEC	TCGA	VRSTS	DEG_SPOP_SBC_1	1748:1752	Mutation rewiring degron network	0.3056
p.P1753S	DO223286	UCEC	ICGC	VRSTS	DEG_SPOP_SBC_1	1748:1752	Mutation rewiring degron network	0.3056
p.A2186S	TCGA-E6-A1M0	UCEC	TCGA	PQTSS	DEG_SPOP_SBC_1	2173:2177	Mutation rewiring degron network	0.0833
p.A2186S	DO43682	UCEC	ICGC	PQTSS	DEG_SPOP_SBC_1	2173:2177	Mutation rewiring degron network	0.0833
p.P2308L	TCGA-EE-A181	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	2307:2311	Mutation altering degron motif	0.6471
p.P2308L	DO37444	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	2307:2311	Mutation altering degron motif	0.6471
p.T2223A	TCGA-EO-A22R	UCEC	TCGA	VTVFTE	LIG_APCC_ABBA_1	2222:2227	Mutation altering degron motif	0.6028
p.T2223A	DO42713	UCEC	ICGC	VTVFTE	LIG_APCC_ABBA_1	2222:2227	Mutation altering degron motif	0.6028
p.P1678A	TCGA-EW-A1J5	BRCA	TCGA	IKPTPVVS	DEG_SCF_FBW7_1	1669:1676	Mutation rewiring degron network	0.2778
p.P1678A	DO6144	BRCA	ICGC	IKPTPVVS	DEG_SCF_FBW7_1	1669:1676	Mutation rewiring degron network	0.2778
p.R2165Q	TCGA-KN-8428	KICH	TCGA	PQTSS	DEG_SPOP_SBC_1	2173:2177	Mutation rewiring degron network	0.1111
p.R2165Q	DO220484	KICH	ICGC	PQTSS	DEG_SPOP_SBC_1	2173:2177	Mutation rewiring degron network	0.1111
p.L2300V	TCGA-Q1-A73O	CESC	TCGA	PPSSS	DEG_SPOP_SBC_1	2307:2311	Mutation rewiring degron network	0.1389
p.L2300V	DO51612	CESC	ICGC	PPSSS	DEG_SPOP_SBC_1	2307:2311	Mutation rewiring degron network	0.1389
p.S1745G	TCGA-UF-A7JA	HNSC	TCGA	VRSTS	DEG_SPOP_SBC_1	1748:1752	Mutation rewiring degron network	0.25
p.S1745G	DO52112	HNSC	ICGC	VRSTS	DEG_SPOP_SBC_1	1748:1752	Mutation rewiring degron network	0.25
p.K1857T	TCGA-VQ-A8PO	STAD	TCGA	VTPVGT	DEG_SCF_FBW7_1	1862:1867	Mutation substituting flanking lysine	0.3056
p.K1857T	DO51773	STAD	ICGC	VTPVGT	DEG_SCF_FBW7_1	1862:1867	Mutation substituting flanking lysine	0.3056
p.E1875K	DO227807	COCA	ICGC	VTPVGT	DEG_SCF_FBW7_1	1862:1867	Mutation rewiring degron network	0.1111
p.V1806A	DO227987	COCA	ICGC	PSTST	DEG_SPOP_SBC_1	1809:1813	Mutation rewiring degron network	0.25
p.S1810T	DO222809	COCA	ICGC	PSTST	DEG_SPOP_SBC_1	1809:1813	Mutation altering degron motif	0.6005
p.R1749H	DO233652	GACA	ICGC	VRSTS	DEG_SPOP_SBC_1	1748:1752	Mutation altering degron motif	0.7133
p.R1749H	DO229075	PRAD	ICGC	VRSTS	DEG_SPOP_SBC_1	1748:1752	Mutation altering degron motif	0.7133
p.R1749H	DO229459	SKCA	ICGC	VRSTS	DEG_SPOP_SBC_1	1748:1752	Mutation altering degron motif	0.7133
p.P2173S	DO233748	GACA	ICGC	PQTSS	DEG_SPOP_SBC_1	2173:2177	Mutation altering degron motif	0.6752
p.P2173S	DO232761	PBCA	ICGC	PQTSS	DEG_SPOP_SBC_1	2173:2177	Mutation altering degron motif	0.6752
p.V1717A	DO233939	GACA	ICGC	TPTATVMPT	DEG_SIAH_1	1712:1720	Mutation altering degron motif	0.6936
p.P2212L	DO49684	LIAD	ICGC	VTVFTE	LIG_APCC_ABBA_1	2222:2227	Mutation rewiring degron network	0.0556
p.S2247Y	DO228974	LICA	ICGC	VTTST	DEG_SPOP_SBC_1	2244:2248	Mutation altering degron motif	0.712
p.P2173Q	DO228974	LICA	ICGC	PQTSS	DEG_SPOP_SBC_1	2173:2177	Mutation altering degron motif	0.7035
p.P2242T	DO228986	LICA	ICGC	VTTST	DEG_SPOP_SBC_1	2244:2248	Mutation rewiring degron network	0.2778
p.T2246K	DO229018	LICA	ICGC	VTTST	DEG_SPOP_SBC_1	2244:2248	Mutation altering degron motif	0.7306
p.Q2239K	DO229015	LICA	ICGC	VTTST	DEG_SPOP_SBC_1	2244:2248	Mutation rewiring degron network	0.1944
p.T1705N	DO229015	LICA	ICGC	PTTTPTAT	DEG_SCF_FBW7_1	1709:1716	Mutation rewiring degron network	0.2222
p.T1705N	DO229015	LICA	ICGC	TPTATVMPT	DEG_SIAH_1	1712:1720	Mutation rewiring degron network	0.1389
p.T1831K	DO229022	LICA	ICGC	VSATPSSS	DEG_SCF_FBW7_1	1819:1826	Mutation blocking phosphorylation signal	0.6389
p.S2312Y	DO229024	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	2307:2311	Mutation rewiring degron network	0.3056
p.S2312Y	DO229024	LICA	ICGC	VDTSS	DEG_SPOP_SBC_1	2313:2317	Mutation rewiring degron network	0.3056
p.P1671Q	DO229027	LICA	ICGC	IKPTPVVS	DEG_SCF_FBW7_1	1669:1676	Mutation altering degron motif	0.5924
p.P1671Q	DO229026	LICA	ICGC	IKPTPVVS	DEG_SCF_FBW7_1	1669:1676	Mutation altering degron motif	0.5924
p.A1873E	DO229038	LICA	ICGC	VTPVGT	DEG_SCF_FBW7_1	1862:1867	Mutation rewiring degron network	0.1667
p.S1743R	DO229037	LICA	ICGC	VRSTS	DEG_SPOP_SBC_1	1748:1752	Mutation rewiring degron network	0.1944
p.Q1730K	DO229041	LICA	ICGC	TPTATVMPT	DEG_SIAH_1	1712:1720	Mutation rewiring degron network	0.0556
p.A1684E	DO229041	LICA	ICGC	IKPTPVVS	DEG_SCF_FBW7_1	1669:1676	Mutation rewiring degron network	0.1111
p.T2213S	DO48719	LIRI	ICGC	VTVFTE	LIG_APCC_ABBA_1	2222:2227	Mutation rewiring degron network	0.0833
p.N1668I	DO52692	MALY	ICGC	IKPTPVVS	DEG_SCF_FBW7_1	1669:1676	Mutation rewiring degron network	0.3056
p.A2186P	DO231798	NBL	ICGC	PQTSS	DEG_SPOP_SBC_1	2173:2177	Mutation rewiring degron network	0.0833
p.S2234L	DO232224	PBCA	ICGC	VTTST	DEG_SPOP_SBC_1	2244:2248	Mutation rewiring degron network	0.0556
p.S2234L	DO232224	PBCA	ICGC	VTVFTE	LIG_APCC_ABBA_1	2222:2227	Mutation rewiring degron network	0.1389
p.T1682I	DO229211	THCA	ICGC	IKPTPVVS	DEG_SCF_FBW7_1	1669:1676	Mutation blocking phosphorylation signal	0.6111
p.A1704P	DO229232	THCA	ICGC	PTTTPTAT	DEG_SCF_FBW7_1	1709:1716	Mutation rewiring degron network	0.1944
p.A1704P	DO229232	THCA	ICGC	TPTATVMPT	DEG_SIAH_1	1712:1720	Mutation rewiring degron network	0.1111
p.S2310R	DO41199	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	2307:2311	Mutation altering degron motif	0.7427
p.K1858N	SIDM01299	Colorectal Carcinoma	GDSC	VTPVGT	DEG_SCF_FBW7_1	1862:1867	Mutation substituting flanking lysine	0.3333
p.T2254A	SIDM01278	Colorectal Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	2244:2248	Mutation rewiring degron network	0.1667
p.S2228R	SIDM00662	Melanoma	GDSC	VTVFTE	LIG_APCC_ABBA_1	2222:2227	Mutation rewiring degron network	0.3056
p.S2228R	ACH-000135	Non-Cancerous	CCLE	VTVFTE	LIG_APCC_ABBA_1	2222:2227	Mutation rewiring degron network	0.3056
p.S2228R	Hs940-T	skin	COSMIC	VTVFTE	LIG_APCC_ABBA_1	2222:2227	Mutation rewiring degron network	0.3056
p.T2315A	SIDM00447	B-Lymphoblastic Leukemia	GDSC	VDTSS	DEG_SPOP_SBC_1	2313:2317	Mutation altering degron motif	0.7139
p.T2315A	ACH-000960	Leukemia	CCLE	VDTSS	DEG_SPOP_SBC_1	2313:2317	Mutation altering degron motif	0.7139
p.T2315A	ACH-000982	Colon/Colorectal Cancer	CCLE	VDTSS	DEG_SPOP_SBC_1	2313:2317	Mutation altering degron motif	0.7139
p.T2315A	REH	haematopoietic and lymphoid tissue	COSMIC	VDTSS	DEG_SPOP_SBC_1	2313:2317	Mutation altering degron motif	0.7139
p.T1677A	SIDM00447	B-Lymphoblastic Leukemia	GDSC	IKPTPVVS	DEG_SCF_FBW7_1	1669:1676	Mutation blocking phosphorylation signal	0.75
p.T1677A	ACH-000960	Leukemia	CCLE	IKPTPVVS	DEG_SCF_FBW7_1	1669:1676	Mutation blocking phosphorylation signal	0.75
p.T1677A	REH	haematopoietic and lymphoid tissue	COSMIC	IKPTPVVS	DEG_SCF_FBW7_1	1669:1676	Mutation blocking phosphorylation signal	0.75
p.P2168S	SIDM00267	Biliary Tract Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	2173:2177	Mutation rewiring degron network	0.1944
p.P2168S	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	2173:2177	Mutation rewiring degron network	0.1944
p.P2168S	SIDM01100	Neuroblastoma	GDSC	PQTSS	DEG_SPOP_SBC_1	2173:2177	Mutation rewiring degron network	0.1944
p.P2168S	SIDM01187	Breast Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	2173:2177	Mutation rewiring degron network	0.1944
p.P2168S	SIDM00068	Colorectal Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	2173:2177	Mutation rewiring degron network	0.1944
p.P2168S	SIDM00760	Small Cell Lung Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	2173:2177	Mutation rewiring degron network	0.1944
p.P2168S	SIDM01686	Chronic Myelogenous Leukemia	GDSC	PQTSS	DEG_SPOP_SBC_1	2173:2177	Mutation rewiring degron network	0.1944
p.D2181A	SIDM00889	Cervical Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	2173:2177	Mutation rewiring degron network	0.2222
p.D2181A	ACH-001333	Cervical Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	2173:2177	Mutation rewiring degron network	0.2222
p.D2181A	C-33-A	cervix	COSMIC	PQTSS	DEG_SPOP_SBC_1	2173:2177	Mutation rewiring degron network	0.2222
p.S1758F	SIDM00708	Non-Small Cell Lung Carcinoma	GDSC	VRSTS	DEG_SPOP_SBC_1	1748:1752	Mutation rewiring degron network	0.1667
p.S1758F	ACH-000841	Lung Cancer	CCLE	VRSTS	DEG_SPOP_SBC_1	1748:1752	Mutation rewiring degron network	0.1667
p.S1758F	NCI-H2087	lung	COSMIC	VRSTS	DEG_SPOP_SBC_1	1748:1752	Mutation rewiring degron network	0.1667
p.M1872V	SIDM01113	Other Sarcomas	GDSC	VTPVGT	DEG_SCF_FBW7_1	1862:1867	Mutation rewiring degron network	0.1944
p.M1872V	SK-UT-1	soft tissue	COSMIC	VTPVGT	DEG_SCF_FBW7_1	1862:1867	Mutation rewiring degron network	0.1944
p.E1807K	SIDM00562	Breast Carcinoma	GDSC	PSTST	DEG_SPOP_SBC_1	1809:1813	Mutation rewiring degron network	0.2778
p.E1807K	ACH-002163	Breast Cancer	CCLE	PSTST	DEG_SPOP_SBC_1	1809:1813	Mutation rewiring degron network	0.2778
p.E1807K	MRK-nu-1	breast	COSMIC	PSTST	DEG_SPOP_SBC_1	1809:1813	Mutation rewiring degron network	0.2778
p.V1748I	SIDM00151	Ovarian Carcinoma	GDSC	VRSTS	DEG_SPOP_SBC_1	1748:1752	Mutation altering degron motif	0.7076
p.S1824N	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	VSATPSSS	DEG_SCF_FBW7_1	1819:1826	Mutation altering degron motif	0.5958
p.S1824N	ACH-000785	Lung Cancer	CCLE	VSATPSSS	DEG_SCF_FBW7_1	1819:1826	Mutation altering degron motif	0.5958
p.S1824N	NCI-H2126	lung	COSMIC	VSATPSSS	DEG_SCF_FBW7_1	1819:1826	Mutation altering degron motif	0.5958
p.A1704G	SIDM00105	Ovarian Carcinoma	GDSC	PTTTPTAT	DEG_SCF_FBW7_1	1709:1716	Mutation rewiring degron network	0.1944
p.A1704G	SIDM00105	Ovarian Carcinoma	GDSC	TPTATVMPT	DEG_SIAH_1	1712:1720	Mutation rewiring degron network	0.1111
p.A1704G	SIDM00093	Ovarian Carcinoma	GDSC	PTTTPTAT	DEG_SCF_FBW7_1	1709:1716	Mutation rewiring degron network	0.1944
p.A1704G	SIDM00093	Ovarian Carcinoma	GDSC	TPTATVMPT	DEG_SIAH_1	1712:1720	Mutation rewiring degron network	0.1111
p.T2229N	SIDM00241	Breast Carcinoma	GDSC	VTVFTE	LIG_APCC_ABBA_1	2222:2227	Mutation rewiring degron network	0.2778
p.T2229N	ACH-002179	Breast Cancer	CCLE	VTVFTE	LIG_APCC_ABBA_1	2222:2227	Mutation rewiring degron network	0.2778
p.T2229N	OCUB-M	breast	COSMIC	VTVFTE	LIG_APCC_ABBA_1	2222:2227	Mutation rewiring degron network	0.2778
p.S1824G	SIDM00677	Colorectal Carcinoma	GDSC	VSATPSSS	DEG_SCF_FBW7_1	1819:1826	Mutation altering degron motif	0.5882
p.S1824G	ACH-000007	Colon/Colorectal Cancer	CCLE	VSATPSSS	DEG_SCF_FBW7_1	1819:1826	Mutation altering degron motif	0.5882
p.S1824G	LS-513	large intestine	COSMIC	VSATPSSS	DEG_SCF_FBW7_1	1819:1826	Mutation altering degron motif	0.5882
p.R1749S	SIDM00850	Gastric Carcinoma	GDSC	VRSTS	DEG_SPOP_SBC_1	1748:1752	Mutation altering degron motif	0.6316
p.R1749S	ACH-000880	Gastric Cancer	CCLE	VRSTS	DEG_SPOP_SBC_1	1748:1752	Mutation altering degron motif	0.6316
p.R1749S	AGS	stomach	COSMIC	VRSTS	DEG_SPOP_SBC_1	1748:1752	Mutation altering degron motif	0.6316
p.H2236P	SIDM01728	Endometrial Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	2244:2248	Mutation rewiring degron network	0.1111
p.H2236P	SIDM01728	Endometrial Carcinoma	GDSC	VTVFTE	LIG_APCC_ABBA_1	2222:2227	Mutation rewiring degron network	0.0833
p.H2236P	SIDM01321	Pancreatic Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	2244:2248	Mutation rewiring degron network	0.1111
p.H2236P	SIDM01321	Pancreatic Carcinoma	GDSC	VTVFTE	LIG_APCC_ABBA_1	2222:2227	Mutation rewiring degron network	0.0833
p.H2236P	ACH-000173	Endometrial/Uterine Cancer	CCLE	VTTST	DEG_SPOP_SBC_1	2244:2248	Mutation rewiring degron network	0.1111
p.H2236P	ACH-000173	Endometrial/Uterine Cancer	CCLE	VTVFTE	LIG_APCC_ABBA_1	2222:2227	Mutation rewiring degron network	0.0833
p.H2236P	ACH-000307	Pancreatic Cancer	CCLE	VTTST	DEG_SPOP_SBC_1	2244:2248	Mutation rewiring degron network	0.1111
p.H2236P	ACH-000307	Pancreatic Cancer	CCLE	VTVFTE	LIG_APCC_ABBA_1	2222:2227	Mutation rewiring degron network	0.0833
p.H2236P	ACH-001518	Endometrial/Uterine Cancer	CCLE	VTTST	DEG_SPOP_SBC_1	2244:2248	Mutation rewiring degron network	0.1111
p.H2236P	ACH-001518	Endometrial/Uterine Cancer	CCLE	VTVFTE	LIG_APCC_ABBA_1	2222:2227	Mutation rewiring degron network	0.0833
p.T2248A	SIDM01609	Endometrial Carcinoma	GDSC	VTTST	DEG_SPOP_SBC_1	2244:2248	Mutation altering degron motif	0.7139
p.T2248A	ACH-000972	Endometrial/Uterine Cancer	CCLE	VTTST	DEG_SPOP_SBC_1	2244:2248	Mutation altering degron motif	0.7139
p.T2226I	SIDM01608	Endometrial Carcinoma	GDSC	VTVFTE	LIG_APCC_ABBA_1	2222:2227	Mutation altering degron motif	0.5966
p.T2226I	ACH-000990	Endometrial/Uterine Cancer	CCLE	VTVFTE	LIG_APCC_ABBA_1	2222:2227	Mutation altering degron motif	0.5966
p.A2220V	SIDM01608	Endometrial Carcinoma	GDSC	VTVFTE	LIG_APCC_ABBA_1	2222:2227	Mutation rewiring degron network	0.2778
p.A2220V	ACH-000990	Endometrial/Uterine Cancer	CCLE	VTVFTE	LIG_APCC_ABBA_1	2222:2227	Mutation rewiring degron network	0.2778
p.H2179D	SIDM01577	Plasma Cell Myeloma	GDSC	PQTSS	DEG_SPOP_SBC_1	2173:2177	Mutation rewiring degron network	0.2778
p.H2179D	ACH-000889	Myeloma	CCLE	PQTSS	DEG_SPOP_SBC_1	2173:2177	Mutation rewiring degron network	0.2778
p.T1822N	ACH-000008	Skin Cancer	CCLE	VSATPSSS	DEG_SCF_FBW7_1	1819:1826	Mutation altering degron motif	0.8166
p.T1822N	ACH-000202	Colon/Colorectal Cancer	CCLE	VSATPSSS	DEG_SCF_FBW7_1	1819:1826	Mutation altering degron motif	0.8166
p.T1822N	ACH-000219	Skin Cancer	CCLE	VSATPSSS	DEG_SCF_FBW7_1	1819:1826	Mutation altering degron motif	0.8166
p.T1822N	ACH-000491	Colon/Colorectal Cancer	CCLE	VSATPSSS	DEG_SCF_FBW7_1	1819:1826	Mutation altering degron motif	0.8166
p.T1822N	ACH-000565	Colon/Colorectal Cancer	CCLE	VSATPSSS	DEG_SCF_FBW7_1	1819:1826	Mutation altering degron motif	0.8166
p.T1822N	ACH-002173	Lung Cancer	CCLE	VSATPSSS	DEG_SCF_FBW7_1	1819:1826	Mutation altering degron motif	0.8166
p.I1759V	ACH-000829	Myeloma	CCLE	VRSTS	DEG_SPOP_SBC_1	1748:1752	Mutation rewiring degron network	0.1389
p.S2176T	ACH-001097	Lymphoma	CCLE	PQTSS	DEG_SPOP_SBC_1	2173:2177	Mutation altering degron motif	0.6005
p.S1861I	ACH-001377	Pancreatic Cancer	CCLE	VTPVGT	DEG_SCF_FBW7_1	1862:1867	Mutation rewiring degron network	0.3056
p.L2251F	ACH-001610	Brain Cancer	CCLE	VTTST	DEG_SPOP_SBC_1	2244:2248	Mutation rewiring degron network	0.25
p.K1857R	ACH-001786	Colon/Colorectal Cancer	CCLE	VTPVGT	DEG_SCF_FBW7_1	1862:1867	Mutation substituting flanking lysine	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TPR

UniProt ID: P12270

Entrez ID: 7175

Protein name: Nucleoprotein TPR (Megator) (NPC-associated intranuclear protein) (Translocated promoter region protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TPR in