DegronMD

Uniprot ID: P12270

Source protein: Nucleoprotein TPR

Source gene: TPR

Class: DEG_SCF_FBW7_1

Location: 1669:1676

E3 ligase: FBXW7

DEGRON score: 0.9978

ASA_SCORE: 104.0375

COIL: 0.9653

CONS_SCORE: 0.5341

DSS_SCORE: 0.6099

HELIX: 0.0093

FCONS_SCORE: 1.0463

RIG_SCORE: 0.6876

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M1686T	TCGA-34-5236	LUSC	TCGA	IKPTPVVS	DEG_SCF_FBW7_1	0.0556
p.M1686T	DO26778	LUSC	ICGC	IKPTPVVS	DEG_SCF_FBW7_1	0.0556
p.P1678A	TCGA-EW-A1J5	BRCA	TCGA	IKPTPVVS	DEG_SCF_FBW7_1	0.2778
p.P1678A	DO6144	BRCA	ICGC	IKPTPVVS	DEG_SCF_FBW7_1	0.2778
p.P1671Q	DO229027	LICA	ICGC	IKPTPVVS	DEG_SCF_FBW7_1	0.5924
p.P1671Q	DO229026	LICA	ICGC	IKPTPVVS	DEG_SCF_FBW7_1	0.5924
p.A1684E	DO229041	LICA	ICGC	IKPTPVVS	DEG_SCF_FBW7_1	0.1111
p.N1668I	DO52692	MALY	ICGC	IKPTPVVS	DEG_SCF_FBW7_1	0.3056
p.T1682I	DO229211	THCA	ICGC	IKPTPVVS	DEG_SCF_FBW7_1	0.6111
p.T1677A	SIDM00447	B-Lymphoblastic Leukemia	GDSC	IKPTPVVS	DEG_SCF_FBW7_1	0.75
p.T1677A	ACH-000960	Leukemia	CCLE	IKPTPVVS	DEG_SCF_FBW7_1	0.75
p.T1677A	REH	haematopoietic_and_lymphoid_tissue	COSMIC	IKPTPVVS	DEG_SCF_FBW7_1	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12270	Nucleoprotein TPR	DEG_SCF_FBW7_1	1669:1676	IKPTPVVS	FBXW7	0.9978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons