DegronMD

Uniprot ID: P12270

Source protein: Nucleoprotein TPR

Source gene: TPR

Class: DEG_SIAH_1

Location: 1712:1720

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9752

ASA_SCORE: 93.7

COIL: 0.9274

CONS_SCORE: 0.5372

DSS_SCORE: 0.6656

HELIX: 0.0181

FCONS_SCORE: 1.0415

RIG_SCORE: 0.7401

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1724K	TCGA-BT-A42F	BLCA	TCGA	TPTATVMPT	DEG_SIAH_1	0.2222
p.E1724K	DO49726	BLCA	ICGC	TPTATVMPT	DEG_SIAH_1	0.2222
p.V1717A	DO233939	GACA	ICGC	TPTATVMPT	DEG_SIAH_1	0.6936
p.T1705N	DO229015	LICA	ICGC	TPTATVMPT	DEG_SIAH_1	0.1389
p.Q1730K	DO229041	LICA	ICGC	TPTATVMPT	DEG_SIAH_1	0.0556
p.A1704P	DO229232	THCA	ICGC	TPTATVMPT	DEG_SIAH_1	0.1111
p.A1704G	SIDM00105	Ovarian Carcinoma	GDSC	TPTATVMPT	DEG_SIAH_1	0.1111
p.A1704G	SIDM00093	Ovarian Carcinoma	GDSC	TPTATVMPT	DEG_SIAH_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12270	Nucleoprotein TPR	DEG_SIAH_1	1712:1720	TPTATVMPT	SIAH1,SIAH2,SIAH3	0.9752	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons