DegronMD

Uniprot ID: P12270

Source protein: Nucleoprotein TPR

Source gene: TPR

Class: DEG_SPOP_SBC_1

Location: 2173:2177

E3 ligase: SPOP

DEGRON score: 0.9863

ASA_SCORE: 75.3

COIL: 0.8718

CONS_SCORE: 0.5077

DSS_SCORE: 0.7278

HELIX: 0.0706

FCONS_SCORE: 0.971

RIG_SCORE: 0.5976

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G2183S	TCGA-76-6191	GBM	TCGA	PQTSS	DEG_SPOP_SBC_1	0.1667
p.E2170K	TCGA-77-7140	LUSC	TCGA	PQTSS	DEG_SPOP_SBC_1	0.25
p.E2170K	DO26455	LUSC	ICGC	PQTSS	DEG_SPOP_SBC_1	0.25
p.A2186S	TCGA-E6-A1M0	UCEC	TCGA	PQTSS	DEG_SPOP_SBC_1	0.0833
p.A2186S	DO43682	UCEC	ICGC	PQTSS	DEG_SPOP_SBC_1	0.0833
p.R2165Q	TCGA-KN-8428	KICH	TCGA	PQTSS	DEG_SPOP_SBC_1	0.1111
p.R2165Q	DO220484	KICH	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1111
p.P2173S	DO233748	GACA	ICGC	PQTSS	DEG_SPOP_SBC_1	0.6752
p.P2173S	DO232761	PBCA	ICGC	PQTSS	DEG_SPOP_SBC_1	0.6752
p.P2173Q	DO228974	LICA	ICGC	PQTSS	DEG_SPOP_SBC_1	0.7035
p.A2186P	DO231798	NBL	ICGC	PQTSS	DEG_SPOP_SBC_1	0.0833
p.P2168S	SIDM00267	Biliary Tract Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.1944
p.P2168S	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.1944
p.P2168S	SIDM01100	Neuroblastoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.1944
p.P2168S	SIDM01187	Breast Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.1944
p.P2168S	SIDM00068	Colorectal Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.1944
p.P2168S	SIDM00760	Small Cell Lung Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.1944
p.P2168S	SIDM01686	Chronic Myelogenous Leukemia	GDSC	PQTSS	DEG_SPOP_SBC_1	0.1944
p.D2181A	SIDM00889	Cervical Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.2222
p.D2181A	ACH-001333	Cervical Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	0.2222
p.D2181A	C-33-A	cervix	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.2222
p.H2179D	SIDM01577	Plasma Cell Myeloma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.2778
p.H2179D	ACH-000889	Myeloma	CCLE	PQTSS	DEG_SPOP_SBC_1	0.2778
p.S2176T	ACH-001097	Lymphoma	CCLE	PQTSS	DEG_SPOP_SBC_1	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95628	CCR4-NOT transcription complex subunit 4	DEG_SPOP_SBC_1	358:362	PQTSS	SPOP	0.8415	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	2173:2177	PQTSS	SPOP	0.9863	More...
P41218	Myeloid cell nuclear differentiation antigen	DEG_SPOP_SBC_1	176:180	PQTSS	SPOP	0.9954	More...
P43694	Transcription factor GATA-4	DEG_SPOP_SBC_1	418:422	PQTSS	SPOP	0.8935	More...
P52564	Dual specificity mitogen-activated protein kinase kinase 6	DEG_SPOP_SBC_1	23:27	PQTSS	SPOP	0.9755	More...
Q09472	Histone acetyltransferase p300	DEG_SPOP_SBC_1	2342:2346	PQTSS	SPOP	0.8022	More...
Q13023	A-kinase anchor protein 6	DEG_SPOP_SBC_1	2232:2236	PQTSS	SPOP	0.9624	More...
Q14118	Dystroglycan 1	DEG_SPOP_SBC_1	146:150	PQTSS	SPOP	0.8524	More...
Q14493	Histone RNA hairpin-binding protein	DEG_SPOP_SBC_1	224:228	PQTSS	SPOP	0.5108	More...
Q6K0P9	Pyrin and HIN domain-containing protein 1	DEG_SPOP_SBC_1	179:183	PQTSS	SPOP	0.9899	More...
Q6KC79	Nipped-B-like protein	DEG_SPOP_SBC_1	158:162	PQTSS	SPOP	0.9956	More...
Q6Y7W6	GRB10-interacting GYF protein 2	DEG_SPOP_SBC_1	371:375	PQTSS	SPOP	0.9311	More...
Q8IX01	SURP and G-patch domain-containing protein 2	DEG_SPOP_SBC_1	769:773	PQTSS	SPOP	0.9694	More...
Q8IYB3	Serine/arginine repetitive matrix protein 1	DEG_SPOP_SBC_1	691:695	PQTSS	SPOP	0.9405	More...
Q96N21	AP-4 complex accessory subunit Tepsin	DEG_SPOP_SBC_1	500:504	PQTSS	SPOP	0.7617	More...
Q96RT1	Erbin	DEG_SPOP_SBC_1	1214:1218	PQTSS	SPOP	0.8905	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	947:951	PQTSS	SPOP	0.7773	More...
Q9P2G1	Ankyrin repeat and IBR domain-containing protein 1	DEG_SPOP_SBC_1	1076:1080	PQTSS	SPOP	0.9754	More...
Q9UFD9	RIMS-binding protein 3A	DEG_SPOP_SBC_1	230:234	PQTSS	SPOP	0.6974	More...
A6NJZ7	RIMS-binding protein 3C	DEG_SPOP_SBC_1	230:234	PQTSS	SPOP	0.683	More...
A6NNM3	RIMS-binding protein 3B	DEG_SPOP_SBC_1	230:234	PQTSS	SPOP	0.6974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PQTSS

Degron related mutations and impact score

Drug responses associated with TPR mutations

All proteins holding degron of PQTSS