DegronMD - Q96N21(TEPSIN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G403E	SIDM01004	Chronic Myelogenous Leukemia	GDSC	LSSTPVSS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.2778
p.G403E	SIDM01004	Chronic Myelogenous Leukemia	GDSC	PLSST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.1667
p.G403E	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	LSSTPVSS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.2778
p.G403E	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	PLSST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.1667
p.G403E	SIDM00299	Other Sarcomas	GDSC	LSSTPVSS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.2778
p.G403E	SIDM00299	Other Sarcomas	GDSC	PLSST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.1667
p.G403E	SLVL	haematopoietic and lymphoid tissue	COSMIC	LSSTPVSS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.2778
p.G403E	SLVL	haematopoietic and lymphoid tissue	COSMIC	PLSST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.1667
p.G403E	MFH-ino	soft tissue	COSMIC	LSSTPVSS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.2778
p.G403E	MFH-ino	soft tissue	COSMIC	PLSST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.1667
p.G403E	KCL-22	haematopoietic and lymphoid tissue	COSMIC	LSSTPVSS	DEG_SCF_FBW7_1	394:401	Mutation rewiring degron network	0.2778
p.G403E	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PLSST	DEG_SPOP_SBC_1	393:397	Mutation rewiring degron network	0.1667
p.R158G	SIDM00846	Cervical Carcinoma	GDSC	PLGTPPAT	DEG_SCF_FBW7_1	144:151	Mutation rewiring degron network	0.1389
p.R158G	SIDM01133	Other Solid Cancers	GDSC	PLGTPPAT	DEG_SCF_FBW7_1	144:151	Mutation rewiring degron network	0.1389
p.R158G	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PLGTPPAT	DEG_SCF_FBW7_1	144:151	Mutation rewiring degron network	0.1389
p.R158G	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PLGTPPAT	DEG_SCF_FBW7_1	144:151	Mutation rewiring degron network	0.1389
p.R158G	SIDM00628	Breast Carcinoma	GDSC	PLGTPPAT	DEG_SCF_FBW7_1	144:151	Mutation rewiring degron network	0.1389
p.R158G	SIDM01664	Prostate Carcinoma	GDSC	PLGTPPAT	DEG_SCF_FBW7_1	144:151	Mutation rewiring degron network	0.1389
p.M153I	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PLGTPPAT	DEG_SCF_FBW7_1	144:151	Mutation rewiring degron network	0.2778
p.M153I	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	PLGTPPAT	DEG_SCF_FBW7_1	144:151	Mutation rewiring degron network	0.2778
p.S155F	SIDM01147	Gastric Carcinoma	GDSC	PLGTPPAT	DEG_SCF_FBW7_1	144:151	Mutation rewiring degron network	0.2222
p.P514S	SIDM00740	Squamous Cell Lung Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0556
p.P514S	NCI-H1703	lung	COSMIC	PQTSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.0556
p.S200F	MEL-JUSO	skin	COSMIC	DSGPSS	DEG_SCF_TRCP1_1	192:197	Mutation rewiring degron network	0.25
p.A499T	IM-95	stomach	COSMIC	PQTSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.3056
p.G186E	SK-MEL-31	skin	COSMIC	DSGPSS	DEG_SCF_TRCP1_1	192:197	Mutation rewiring degron network	0.1667
p.G186E	RCC-FG2	kidney	COSMIC	DSGPSS	DEG_SCF_TRCP1_1	192:197	Mutation rewiring degron network	0.1667
p.R498H	P31-FUJ	haematopoietic and lymphoid tissue	COSMIC	PQTSS	DEG_SPOP_SBC_1	500:504	Mutation rewiring degron network	0.2778

Kaplan plot for TEPSIN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TEPSIN

UniProt ID: Q96N21

Entrez ID: 146705

Protein name: AP-4 complex accessory subunit Tepsin (ENTH domain-containing protein 2) (Epsin for AP-4) (Tetra-epsin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TEPSIN in