DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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Degron:
DSGPSS
Uniprot ID:
Q96N21
Source protein:
AP-4 complex accessory subunit Tepsin
Source gene:
TEPSIN
Class:
DEG_SCF_TRCP1_1
Location:
192:197
E3 ligase:
BTRC
DEGRON score:
0.9821
ASA_SCORE:
67.05
COIL:
0.9212
CONS_SCORE:
0.3813
DSS_SCORE:
0.7567
HELIX:
0.0425
FCONS_SCORE:
0.8534
RIG_SCORE:
0.5741
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S200F
MEL-JUSO
skin
COSMIC
DSGPSS
DEG_SCF_TRCP1_1
0.25
p.G186E
SK-MEL-31
skin
COSMIC
DSGPSS
DEG_SCF_TRCP1_1
0.1667
p.G186E
RCC-FG2
kidney
COSMIC
DSGPSS
DEG_SCF_TRCP1_1
0.1667
Drug responses associated with TEPSIN mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSGPSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q96N21
AP-4 complex accessory subunit Tepsin
DEG_SCF_TRCP1_1
192:197
DSGPSS
BTRC
0.9821
More...