DegronMD

Uniprot ID: Q96N21

Source protein: AP-4 complex accessory subunit Tepsin

Source gene: TEPSIN

Class: DEG_SCF_FBW7_1

Location: 144:151

E3 ligase: FBXW7

DEGRON score: 0.9819

ASA_SCORE: 73.6

COIL: 0.929

CONS_SCORE: 0.3113

DSS_SCORE: 0.6916

HELIX: 0.0205

FCONS_SCORE: 0.8137

RIG_SCORE: 0.6069

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M153I	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PLGTPPAT	DEG_SCF_FBW7_1	0.2778
p.M153I	CCRF-CEM	haematopoietic_and_lymphoid_tissue	COSMIC	PLGTPPAT	DEG_SCF_FBW7_1	0.2778
p.S155F	SIDM01147	Gastric Carcinoma	GDSC	PLGTPPAT	DEG_SCF_FBW7_1	0.2222
p.R158G	SIDM00846	Cervical Carcinoma	GDSC	PLGTPPAT	DEG_SCF_FBW7_1	0.1389
p.R158G	SIDM01133	Other Solid Cancers	GDSC	PLGTPPAT	DEG_SCF_FBW7_1	0.1389
p.R158G	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PLGTPPAT	DEG_SCF_FBW7_1	0.1389
p.R158G	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PLGTPPAT	DEG_SCF_FBW7_1	0.1389
p.R158G	SIDM00628	Breast Carcinoma	GDSC	PLGTPPAT	DEG_SCF_FBW7_1	0.1389
p.R158G	SIDM01664	Prostate Carcinoma	GDSC	PLGTPPAT	DEG_SCF_FBW7_1	0.1389

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96N21	AP-4 complex accessory subunit Tepsin	DEG_SCF_FBW7_1	144:151	PLGTPPAT	FBXW7	0.9819	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons