DegronMD

Uniprot ID: Q96N21

Source protein: AP-4 complex accessory subunit Tepsin

Source gene: TEPSIN

Class: DEG_SCF_FBW7_1

Location: 394:401

E3 ligase: FBXW7

DEGRON score: 0.9512

ASA_SCORE: 83

COIL: 0.9438

CONS_SCORE: 0.3268

DSS_SCORE: 0.6083

HELIX: 0.0219

FCONS_SCORE: 0.9361

RIG_SCORE: 0.5929

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G403E	SIDM01004	Chronic Myelogenous Leukemia	GDSC	LSSTPVSS	DEG_SCF_FBW7_1	0.2778
p.G403E	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	LSSTPVSS	DEG_SCF_FBW7_1	0.2778
p.G403E	SIDM00299	Other Sarcomas	GDSC	LSSTPVSS	DEG_SCF_FBW7_1	0.2778
p.G403E	SLVL	haematopoietic_and_lymphoid_tissue	COSMIC	LSSTPVSS	DEG_SCF_FBW7_1	0.2778
p.G403E	MFH-ino	soft_tissue	COSMIC	LSSTPVSS	DEG_SCF_FBW7_1	0.2778
p.G403E	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	LSSTPVSS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96N21	AP-4 complex accessory subunit Tepsin	DEG_SCF_FBW7_1	394:401	LSSTPVSS	FBXW7	0.9512	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons