DegronMD

Uniprot ID: Q6K0P9

Source protein: Pyrin and HIN domain-containing protein 1

Source gene: PYHIN1

Class: DEG_SPOP_SBC_1

Location: 179:183

E3 ligase: SPOP

DEGRON score: 0.9899

ASA_SCORE: 96.12

COIL: 0.9304

CONS_SCORE: 0.9538

DSS_SCORE: 0.8278

HELIX: 0.0274

FCONS_SCORE: 1.4371

RIG_SCORE: 0.4949

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P186Q	TCGA-44-8120	LUAD	TCGA	PQTSS	DEG_SPOP_SBC_1	0.25
p.P186Q	DO45402	LUAD	ICGC	PQTSS	DEG_SPOP_SBC_1	0.25
p.S191L	TCGA-55-7914	LUAD	TCGA	PQTSS	DEG_SPOP_SBC_1	0.1111
p.S191L	DO23866	LUAD	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1111
p.R175H	TCGA-66-2792	LUSC	TCGA	PQTSS	DEG_SPOP_SBC_1	0.2222
p.R175H	DO26451	LUSC	ICGC	PQTSS	DEG_SPOP_SBC_1	0.2222
p.R175H	DO50416	PRAD	ICGC	PQTSS	DEG_SPOP_SBC_1	0.2222
p.R175H	ACH-001857	Bile Duct Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	0.2222
p.S191A	TCGA-AZ-6598	COAD	TCGA	PQTSS	DEG_SPOP_SBC_1	0.1111
p.S191A	DO10276	COAD	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1111
p.T192A	TCGA-EE-A2GR	SKCM	TCGA	PQTSS	DEG_SPOP_SBC_1	0.0833
p.T192A	DO37996	SKCM	ICGC	PQTSS	DEG_SPOP_SBC_1	0.0833
p.S183L	TCGA-EE-A2M6	SKCM	TCGA	PQTSS	DEG_SPOP_SBC_1	0.7667
p.S183L	DO222514	MELA	ICGC	PQTSS	DEG_SPOP_SBC_1	0.7667
p.S183L	DO37976	SKCM	ICGC	PQTSS	DEG_SPOP_SBC_1	0.7667
p.S183L	ACH-001414	Bladder Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	0.7667
p.S182L	TCGA-EO-A22U	UCEC	TCGA	PQTSS	DEG_SPOP_SBC_1	0.7667
p.S182L	DO43755	UCEC	ICGC	PQTSS	DEG_SPOP_SBC_1	0.7667
p.P179S	TCGA-FW-A3R5	SKCM	TCGA	PQTSS	DEG_SPOP_SBC_1	0.6752
p.P179S	DO37406	SKCM	ICGC	PQTSS	DEG_SPOP_SBC_1	0.6752
p.H193Y	DO225054	BRCA	ICGC	PQTSS	DEG_SPOP_SBC_1	0.0556
p.H193R	DO234470	ESAD	ICGC	PQTSS	DEG_SPOP_SBC_1	0.0556
p.A172V	DO234437	ESAD	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1389
p.R175C	DO233757	GACA	ICGC	PQTSS	DEG_SPOP_SBC_1	0.2222
p.H193Q	DO23576	LUAD	ICGC	PQTSS	DEG_SPOP_SBC_1	0.0556
p.H193Q	DO223725	LUSC	ICGC	PQTSS	DEG_SPOP_SBC_1	0.0556
p.P179L	DO222662	MELA	ICGC	PQTSS	DEG_SPOP_SBC_1	0.7582
p.P179L	SIDM00140	Melanoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.7582
p.P179L	ACH-000968	Skin Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	0.7582
p.P179L	COLO-792	skin	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.7582
p.A190T	DO41199	UCEC	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1389
p.S190F	SIDM00619	Thyroid Gland Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.1389
p.S190F	ACH-002397	Thyroid Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	0.1389
p.S190F	KMH-2	thyroid	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.1389
p.P178R	SIDM00159	Biliary Tract Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.3056
p.S181F	KMH-2	thyroid	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95628	CCR4-NOT transcription complex subunit 4	DEG_SPOP_SBC_1	358:362	PQTSS	SPOP	0.8415	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	2173:2177	PQTSS	SPOP	0.9863	More...
P41218	Myeloid cell nuclear differentiation antigen	DEG_SPOP_SBC_1	176:180	PQTSS	SPOP	0.9954	More...
P43694	Transcription factor GATA-4	DEG_SPOP_SBC_1	418:422	PQTSS	SPOP	0.8935	More...
P52564	Dual specificity mitogen-activated protein kinase kinase 6	DEG_SPOP_SBC_1	23:27	PQTSS	SPOP	0.9755	More...
Q09472	Histone acetyltransferase p300	DEG_SPOP_SBC_1	2342:2346	PQTSS	SPOP	0.8022	More...
Q13023	A-kinase anchor protein 6	DEG_SPOP_SBC_1	2232:2236	PQTSS	SPOP	0.9624	More...
Q14118	Dystroglycan 1	DEG_SPOP_SBC_1	146:150	PQTSS	SPOP	0.8524	More...
Q14493	Histone RNA hairpin-binding protein	DEG_SPOP_SBC_1	224:228	PQTSS	SPOP	0.5108	More...
Q6K0P9	Pyrin and HIN domain-containing protein 1	DEG_SPOP_SBC_1	179:183	PQTSS	SPOP	0.9899	More...
Q6KC79	Nipped-B-like protein	DEG_SPOP_SBC_1	158:162	PQTSS	SPOP	0.9956	More...
Q6Y7W6	GRB10-interacting GYF protein 2	DEG_SPOP_SBC_1	371:375	PQTSS	SPOP	0.9311	More...
Q8IX01	SURP and G-patch domain-containing protein 2	DEG_SPOP_SBC_1	769:773	PQTSS	SPOP	0.9694	More...
Q8IYB3	Serine/arginine repetitive matrix protein 1	DEG_SPOP_SBC_1	691:695	PQTSS	SPOP	0.9405	More...
Q96N21	AP-4 complex accessory subunit Tepsin	DEG_SPOP_SBC_1	500:504	PQTSS	SPOP	0.7617	More...
Q96RT1	Erbin	DEG_SPOP_SBC_1	1214:1218	PQTSS	SPOP	0.8905	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	947:951	PQTSS	SPOP	0.7773	More...
Q9P2G1	Ankyrin repeat and IBR domain-containing protein 1	DEG_SPOP_SBC_1	1076:1080	PQTSS	SPOP	0.9754	More...
Q9UFD9	RIMS-binding protein 3A	DEG_SPOP_SBC_1	230:234	PQTSS	SPOP	0.6974	More...
A6NJZ7	RIMS-binding protein 3C	DEG_SPOP_SBC_1	230:234	PQTSS	SPOP	0.683	More...
A6NNM3	RIMS-binding protein 3B	DEG_SPOP_SBC_1	230:234	PQTSS	SPOP	0.6974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PQTSS

Degron related mutations and impact score

Drug responses associated with PYHIN1 mutations

All proteins holding degron of PQTSS