DegronMD - P43694(GATA4)

GO - Biological processes (BP): aortic valve morphogenesis [GO:0003180]; atrial septum morphogenesis [GO:0060413]; atrial septum primum morphogenesis [GO:0003289]; atrial septum secundum morphogenesis [GO:0003290]; atrioventricular canal development [GO:0036302]; atrioventricular node development [GO:0003162]; atrioventricular valve formation [GO:0003190]; cardiac muscle tissue regeneration [GO:0061026]; cardiac right ventricle morphogenesis [GO:0003215]; cardiac ventricle morphogenesis [GO:0003208]; cell-cell signaling [GO:0007267]; cell fate commitment [GO:0045165]; cell growth involved in cardiac muscle cell development [GO:0061049]; cellular response to glucose stimulus [GO:0071333]; embryonic foregut morphogenesis [GO:0048617]; embryonic heart tube anterior/posterior pattern specification [GO:0035054]; endocardial cushion development [GO:0003197]; endoderm development [GO:0007492]; heart looping [GO:0001947]; intestinal epithelial cell differentiation [GO:0060575]; male gonad development [GO:0008584]; negative regulation of apoptotic signaling pathway [GO:2001234]; negative regulation of autophagy [GO:0010507]; negative regulation of cardiac muscle cell apoptotic process [GO:0010667]; negative regulation of oxidative stress-induced cell death [GO:1903202]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of angiogenesis [GO:0045766]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cardioblast differentiation [GO:0051891]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of vascular endothelial growth factor production [GO:0010575]; regulation of cardiac muscle cell contraction [GO:0086004]; regulation of protein kinase B signaling [GO:0051896]; regulation of transcription, DNA-templated [GO:0006355]; response to mechanical stimulus [GO:0009612]; response to vitamin A [GO:0033189]; response to xenobiotic stimulus [GO:0009410]; transdifferentiation [GO:0060290]; ventricular septum development [GO:0003281]; wound healing [GO:0042060] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E216V	TCGA-55-8619	LUAD	TCGA	LDMFDD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.1667
p.E359K	TCGA-98-8020	LUSC	TCGA	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.2778
p.R362C	TCGA-AP-A0LM	UCEC	TCGA	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.1944
p.R362C	ACH-000979	Prostate Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.1944
p.R362C	DU-145	prostate	COSMIC	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.1944
p.T355S	TCGA-AX-A2HJ	UCEC	TCGA	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation altering degron motif	0.6005
p.T355S	TCGA-BR-4256	STAD	TCGA	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation altering degron motif	0.6005
p.T366M	TCGA-CK-4950	COAD	TCGA	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.0833
p.T366M	TCGA-ND-A4WC	UCS	TCGA	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.0833
p.T366M	ACH-000686	Liver Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.0833
p.D210A	TCGA-D3-A8GQ	SKCM	TCGA	LDMFDD	LIG_APCC_ABBA_1	205:210	Mutation altering degron motif	0.7793
p.A343S	TCGA-DK-A3X2	BLCA	TCGA	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.0556
p.L432S	TCGA-DX-A6B9	SARC	TCGA	PQTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.0556
p.D210N	TCGA-EE-A2MC	SKCM	TCGA	LDMFDD	LIG_APCC_ABBA_1	205:210	Mutation altering degron motif	0.6932
p.D210N	TCGA-IB-7651	PAAD	TCGA	LDMFDD	LIG_APCC_ABBA_1	205:210	Mutation altering degron motif	0.6932
p.E216Q	TCGA-OL-A66I	BRCA	TCGA	LDMFDD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.1667
p.S344I	TCGA-P6-A5OG	ACC	TCGA	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.0833
p.A344S	DO617	BLCA	ICGC	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.0833
p.E217Q	DO44258	BRCA	ICGC	LDMFDD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.1389
p.T367M	DO8506	COAD	ICGC	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.0556
p.T367M	DO234185	ESAD	ICGC	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.0556
p.D211N	DO52456	COCA	ICGC	LDMFDD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.3056
p.D211N	DO46657	PAAD	ICGC	LDMFDD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.3056
p.D211N	DO37559	SKCM	ICGC	LDMFDD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.3056
p.R363C	DO234350	ESAD	ICGC	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.1667
p.R363C	DO43306	UCEC	ICGC	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.1667
p.R363C	SIDM00120	Prostate Carcinoma	GDSC	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.1667
p.R363C	DU-145	prostate	COSMIC	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.1667
p.A344T	DO233156	GACA	ICGC	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.0833
p.T356S	DO233205	GACA	ICGC	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation altering degron motif	0.7116
p.T356S	DO38743	STAD	ICGC	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation altering degron motif	0.7116
p.T356S	DO42105	UCEC	ICGC	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation altering degron motif	0.7116
p.D211Y	DO229018	LICA	ICGC	LDMFDD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.3056
p.W428C	DO229036	LICA	ICGC	PQTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.1667
p.M362I	DO229045	LICA	ICGC	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.1944
p.S352R	DO229051	LICA	ICGC	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.3056
p.P203H	DO25189	LUAD	ICGC	LDMFDD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.2778
p.S86I	DO23744	LUAD	ICGC	DGAAYTPPP	CBL_PTK	95:103	Mutation rewiring degron network	0.0833
p.E217V	DO26102	LUAD	ICGC	LDMFDD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.1389
p.E360K	DO45428	LUSC	ICGC	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.25
p.E217D	DO232045	ORCA	ICGC	LDMFDD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.1389
p.P87L	DO46593	OV	ICGC	DGAAYTPPP	CBL_PTK	95:103	Mutation rewiring degron network	0.1111
p.M27V	DO32851	PACA	ICGC	SSPVYVPTP	DEG_COP1_1	34:42	Mutation rewiring degron network	0.1389
p.D211A	DO51246	SKCM	ICGC	LDMFDD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.3056
p.A412V	SIDM01037	Breast Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	418:422	Mutation blocking phosphorylation signal	0.6111
p.A412V	SIDM00831	Head and Neck Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	418:422	Mutation blocking phosphorylation signal	0.6111
p.A412V	SIDM00127	Oral Cavity Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	418:422	Mutation blocking phosphorylation signal	0.6111
p.A412V	SIDM01164	Glioma	GDSC	PQTSS	DEG_SPOP_SBC_1	418:422	Mutation blocking phosphorylation signal	0.6111
p.A412V	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	418:422	Mutation blocking phosphorylation signal	0.6111
p.S357R	SIDM00064	Hepatocellular Carcinoma	GDSC	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation altering degron motif	0.7427
p.S357R	HLE	liver	COSMIC	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation altering degron motif	0.7427
p.A25V	SIDM01259	B-Lymphoblastic Leukemia	GDSC	SSPVYVPTP	DEG_COP1_1	34:42	Mutation rewiring degron network	0.0833
p.A25V	ACH-001669	Leukemia	CCLE	SSPVYVPTP	DEG_COP1_1	34:42	Mutation rewiring degron network	0.0833
p.G346S	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.1389
p.G346S	BC-3	haematopoietic and lymphoid tissue	COSMIC	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.1389
p.P408Q	SIDM00502	B-Lymphoblastic Leukemia	GDSC	PQTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.0556
p.P408Q	SIDM00381	Cervical Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.0556
p.P408Q	SIDM01588	Endometrial Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.0556
p.P408Q	A4-Fuk	haematopoietic and lymphoid tissue	COSMIC	PQTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.0556
p.P408Q	SKG-IIIa	cervix	COSMIC	PQTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.0556
p.S357T	SIDM00500	Colorectal Carcinoma	GDSC	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation altering degron motif	0.6005
p.V431G	ACH-000024	Myeloma	CCLE	PQTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.0833
p.V431G	ACH-000057	Myeloma	CCLE	PQTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.0833
p.V431G	ACH-000438	Lung Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.0833
p.V431G	ACH-000528	Lung Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.0833
p.V431G	OPM-2	haematopoietic and lymphoid tissue	COSMIC	PQTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.0833
p.V431G	ABC-1	lung	COSMIC	PQTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.0833
p.V431G	LU-65	lung	COSMIC	PQTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.0833
p.S356R	ACH-000393	Liver Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation altering degron motif	0.7427
p.S356R	ACH-001089	Liver Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation altering degron motif	0.7427
p.S356R	HLE	liver	COSMIC	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation altering degron motif	0.7427
p.R195Q	ACH-000982	Colon/Colorectal Cancer	CCLE	LDMFDD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.0556
p.R195Q	ACH-001345	Colon/Colorectal Cancer	CCLE	LDMFDD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.0556
p.Y99C	ACH-001345	Colon/Colorectal Cancer	CCLE	DGAAYTPPP	CBL_PTK	95:103	Mutation altering degron motif	0.7087
p.S357N	ACH-001610	Brain Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation altering degron motif	0.7069
p.P203S	ACH-001973	Metastasis	CCLE	LDMFDD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.2778
p.G36C	NCI-H1944	lung	COSMIC	SSPVYVPTP	DEG_COP1_1	34:42	Mutation altering degron motif	0.76
p.E107D	ChaGo-K-1	lung	COSMIC	DGAAYTPPP	CBL_PTK	95:103	Mutation rewiring degron network	0.2222
p.V430G	OPM-2	haematopoietic and lymphoid tissue	COSMIC	PQTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.1111
p.V430G	ABC-1	lung	COSMIC	PQTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.1111
p.V430G	LU-65	lung	COSMIC	PQTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.1111
p.D219N	MHH-CALL-4	haematopoietic and lymphoid tissue	COSMIC	LDMFDD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.0833
p.M104I	WM278	skin	COSMIC	DGAAYTPPP	CBL_PTK	95:103	Mutation rewiring degron network	0.3056
p.M104I	NCI-H1869	lung	COSMIC	DGAAYTPPP	CBL_PTK	95:103	Mutation rewiring degron network	0.3056
p.P201Q	SKG-IIIa	cervix	COSMIC	LDMFDD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.2222
p.P201Q	A4-Fuk	haematopoietic and lymphoid tissue	COSMIC	LDMFDD	LIG_APCC_ABBA_1	205:210	Mutation rewiring degron network	0.2222
p.G345S	BC-3	haematopoietic and lymphoid tissue	COSMIC	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.1111
p.R361C	DU-145	prostate	COSMIC	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.2222
p.V432G	ABC-1	lung	COSMIC	PQTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.0556
p.V432G	OPM-2	haematopoietic and lymphoid tissue	COSMIC	PQTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.0556
p.V432G	LU-65	lung	COSMIC	PQTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.0556
p.G97E	K2	skin	COSMIC	DGAAYTPPP	CBL_PTK	95:103	Mutation altering degron motif	0.7199
p.G36S	22RV1	prostate	COSMIC	SSPVYVPTP	DEG_COP1_1	34:42	Mutation altering degron motif	0.6993
p.S355R	HLE	liver	COSMIC	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation altering degron motif	0.7427
p.D426N	MHH-CALL-4	haematopoietic and lymphoid tissue	COSMIC	PQTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.2222
p.D424N	MHH-CALL-4	haematopoietic and lymphoid tissue	COSMIC	PQTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.2778
p.D425N	MHH-CALL-4	haematopoietic and lymphoid tissue	COSMIC	PQTSS	DEG_SPOP_SBC_1	418:422	Mutation rewiring degron network	0.25
p.G97R	K2	skin	COSMIC	DGAAYTPPP	CBL_PTK	95:103	Mutation altering degron motif	0.7568
p.G344S	BC-3	haematopoietic and lymphoid tissue	COSMIC	ATTSS	DEG_SPOP_SBC_1	353:357	Mutation rewiring degron network	0.0833

Kaplan plot for GATA4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GATA4

UniProt ID: P43694

Entrez ID: 2626

Protein name: Transcription factor GATA-4 (GATA-binding factor 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GATA4 in