DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DGAAYTPPP
Uniprot ID:
P43694
Source protein:
Transcription factor GATA-4
Source gene:
GATA4
Class:
CBL_PTK
Location:
95:103
E3 ligase:
CBL
DEGRON score:
0.9976
ASA_SCORE:
56
COIL:
0.9208
CONS_SCORE:
0.3701
DSS_SCORE:
0.5636
HELIX:
0.041
FCONS_SCORE:
1.1331
RIG_SCORE:
0.6592
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S86I
DO23744
LUAD
ICGC
DGAAYTPPP
CBL_PTK
0.0833
p.P87L
DO46593
OV
ICGC
DGAAYTPPP
CBL_PTK
0.1111
p.Y99C
ACH-001345
Colon/Colorectal Cancer
CCLE
DGAAYTPPP
CBL_PTK
0.7087
p.E107D
ChaGo-K-1
lung
COSMIC
DGAAYTPPP
CBL_PTK
0.2222
p.M104I
WM278
skin
COSMIC
DGAAYTPPP
CBL_PTK
0.3056
p.M104I
NCI-H1869
lung
COSMIC
DGAAYTPPP
CBL_PTK
0.3056
p.G97E
K2
skin
COSMIC
DGAAYTPPP
CBL_PTK
0.7199
p.G97R
K2
skin
COSMIC
DGAAYTPPP
CBL_PTK
0.7568
Drug responses associated with GATA4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DGAAYTPPP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P43694
Transcription factor GATA-4
CBL_PTK
95:103
DGAAYTPPP
CBL
0.9976
More...
