DegronMD

Uniprot ID: P43694

Source protein: Transcription factor GATA-4

Source gene: GATA4

Class: LIG_APCC_ABBA_1

Location: 205:210

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.879

ASA_SCORE: 63.9

COIL: 0.77

CONS_SCORE: 0.2767

DSS_SCORE: 0.3356

HELIX: 0.1567

FCONS_SCORE: 0.6743

RIG_SCORE: 0.7692

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E216V	TCGA-55-8619	LUAD	TCGA	LDMFDD	LIG_APCC_ABBA_1	0.1667
p.D210A	TCGA-D3-A8GQ	SKCM	TCGA	LDMFDD	LIG_APCC_ABBA_1	0.7793
p.D210N	TCGA-EE-A2MC	SKCM	TCGA	LDMFDD	LIG_APCC_ABBA_1	0.6932
p.D210N	TCGA-IB-7651	PAAD	TCGA	LDMFDD	LIG_APCC_ABBA_1	0.6932
p.E216Q	TCGA-OL-A66I	BRCA	TCGA	LDMFDD	LIG_APCC_ABBA_1	0.1667
p.E217Q	DO44258	BRCA	ICGC	LDMFDD	LIG_APCC_ABBA_1	0.1389
p.D211N	DO52456	COCA	ICGC	LDMFDD	LIG_APCC_ABBA_1	0.3056
p.D211N	DO46657	PAAD	ICGC	LDMFDD	LIG_APCC_ABBA_1	0.3056
p.D211N	DO37559	SKCM	ICGC	LDMFDD	LIG_APCC_ABBA_1	0.3056
p.D211Y	DO229018	LICA	ICGC	LDMFDD	LIG_APCC_ABBA_1	0.3056
p.P203H	DO25189	LUAD	ICGC	LDMFDD	LIG_APCC_ABBA_1	0.2778
p.E217V	DO26102	LUAD	ICGC	LDMFDD	LIG_APCC_ABBA_1	0.1389
p.E217D	DO232045	ORCA	ICGC	LDMFDD	LIG_APCC_ABBA_1	0.1389
p.D211A	DO51246	SKCM	ICGC	LDMFDD	LIG_APCC_ABBA_1	0.3056
p.R195Q	ACH-000982	Colon/Colorectal Cancer	CCLE	LDMFDD	LIG_APCC_ABBA_1	0.0556
p.R195Q	ACH-001345	Colon/Colorectal Cancer	CCLE	LDMFDD	LIG_APCC_ABBA_1	0.0556
p.P203S	ACH-001973	Metastasis	CCLE	LDMFDD	LIG_APCC_ABBA_1	0.2778
p.D219N	MHH-CALL-4	haematopoietic_and_lymphoid_tissue	COSMIC	LDMFDD	LIG_APCC_ABBA_1	0.0833
p.P201Q	SKG-IIIa	cervix	COSMIC	LDMFDD	LIG_APCC_ABBA_1	0.2222
p.P201Q	A4-Fuk	haematopoietic_and_lymphoid_tissue	COSMIC	LDMFDD	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P43694	Transcription factor GATA-4	LIG_APCC_ABBA_1	205:210	LDMFDD	APC,CDC20,FZR1	0.879	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons