DegronMD

Uniprot ID: P43694

Source protein: Transcription factor GATA-4

Source gene: GATA4

Class: DEG_COP1_1

Location: 34:42

E3 ligase: COP1

DEGRON score: 0.9945

ASA_SCORE: 63.1889

COIL: 0.8564

CONS_SCORE: 0.3586

DSS_SCORE: 0.369

HELIX: 0.0102

FCONS_SCORE: 1.0813

RIG_SCORE: 0.7289

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M27V	DO32851	PACA	ICGC	SSPVYVPTP	DEG_COP1_1	0.1389
p.A25V	SIDM01259	B-Lymphoblastic Leukemia	GDSC	SSPVYVPTP	DEG_COP1_1	0.0833
p.A25V	ACH-001669	Leukemia	CCLE	SSPVYVPTP	DEG_COP1_1	0.0833
p.G36C	NCI-H1944	lung	COSMIC	SSPVYVPTP	DEG_COP1_1	0.76
p.G36S	22RV1	prostate	COSMIC	SSPVYVPTP	DEG_COP1_1	0.6993

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P43694	Transcription factor GATA-4	DEG_COP1_1	34:42	SSPVYVPTP	COP1	0.9945	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons