DegronMD

Uniprot ID: P43694

Source protein: Transcription factor GATA-4

Source gene: GATA4

Class: DEG_SPOP_SBC_1

Location: 418:422

E3 ligase: SPOP

DEGRON score: 0.8935

ASA_SCORE: 70.98

COIL: 0.8804

CONS_SCORE: 0.3668

DSS_SCORE: 0.5646

HELIX: 0.0822

FCONS_SCORE: 1.0461

RIG_SCORE: 0.6209

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L432S	TCGA-DX-A6B9	SARC	TCGA	PQTSS	DEG_SPOP_SBC_1	0.0556
p.W428C	DO229036	LICA	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1667
p.A412V	SIDM01037	Breast Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.6111
p.A412V	SIDM00831	Head and Neck Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.6111
p.A412V	SIDM00127	Oral Cavity Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.6111
p.A412V	SIDM01164	Glioma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.6111
p.A412V	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.6111
p.P408Q	SIDM00502	B-Lymphoblastic Leukemia	GDSC	PQTSS	DEG_SPOP_SBC_1	0.0556
p.P408Q	SIDM00381	Cervical Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.0556
p.P408Q	SIDM01588	Endometrial Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.0556
p.P408Q	A4-Fuk	haematopoietic_and_lymphoid_tissue	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.0556
p.P408Q	SKG-IIIa	cervix	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.0556
p.V431G	ACH-000024	Myeloma	CCLE	PQTSS	DEG_SPOP_SBC_1	0.0833
p.V431G	ACH-000057	Myeloma	CCLE	PQTSS	DEG_SPOP_SBC_1	0.0833
p.V431G	ACH-000438	Lung Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	0.0833
p.V431G	ACH-000528	Lung Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	0.0833
p.V431G	OPM-2	haematopoietic_and_lymphoid_tissue	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.0833
p.V431G	ABC-1	lung	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.0833
p.V431G	LU-65	lung	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.0833
p.V430G	OPM-2	haematopoietic_and_lymphoid_tissue	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.1111
p.V430G	ABC-1	lung	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.1111
p.V430G	LU-65	lung	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.1111
p.V432G	ABC-1	lung	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.0556
p.V432G	OPM-2	haematopoietic_and_lymphoid_tissue	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.0556
p.V432G	LU-65	lung	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.0556
p.D426N	MHH-CALL-4	haematopoietic_and_lymphoid_tissue	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.2222
p.D424N	MHH-CALL-4	haematopoietic_and_lymphoid_tissue	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.2778
p.D425N	MHH-CALL-4	haematopoietic_and_lymphoid_tissue	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95628	CCR4-NOT transcription complex subunit 4	DEG_SPOP_SBC_1	358:362	PQTSS	SPOP	0.8415	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	2173:2177	PQTSS	SPOP	0.9863	More...
P41218	Myeloid cell nuclear differentiation antigen	DEG_SPOP_SBC_1	176:180	PQTSS	SPOP	0.9954	More...
P43694	Transcription factor GATA-4	DEG_SPOP_SBC_1	418:422	PQTSS	SPOP	0.8935	More...
P52564	Dual specificity mitogen-activated protein kinase kinase 6	DEG_SPOP_SBC_1	23:27	PQTSS	SPOP	0.9755	More...
Q09472	Histone acetyltransferase p300	DEG_SPOP_SBC_1	2342:2346	PQTSS	SPOP	0.8022	More...
Q13023	A-kinase anchor protein 6	DEG_SPOP_SBC_1	2232:2236	PQTSS	SPOP	0.9624	More...
Q14118	Dystroglycan 1	DEG_SPOP_SBC_1	146:150	PQTSS	SPOP	0.8524	More...
Q14493	Histone RNA hairpin-binding protein	DEG_SPOP_SBC_1	224:228	PQTSS	SPOP	0.5108	More...
Q6K0P9	Pyrin and HIN domain-containing protein 1	DEG_SPOP_SBC_1	179:183	PQTSS	SPOP	0.9899	More...
Q6KC79	Nipped-B-like protein	DEG_SPOP_SBC_1	158:162	PQTSS	SPOP	0.9956	More...
Q6Y7W6	GRB10-interacting GYF protein 2	DEG_SPOP_SBC_1	371:375	PQTSS	SPOP	0.9311	More...
Q8IX01	SURP and G-patch domain-containing protein 2	DEG_SPOP_SBC_1	769:773	PQTSS	SPOP	0.9694	More...
Q8IYB3	Serine/arginine repetitive matrix protein 1	DEG_SPOP_SBC_1	691:695	PQTSS	SPOP	0.9405	More...
Q96N21	AP-4 complex accessory subunit Tepsin	DEG_SPOP_SBC_1	500:504	PQTSS	SPOP	0.7617	More...
Q96RT1	Erbin	DEG_SPOP_SBC_1	1214:1218	PQTSS	SPOP	0.8905	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	947:951	PQTSS	SPOP	0.7773	More...
Q9P2G1	Ankyrin repeat and IBR domain-containing protein 1	DEG_SPOP_SBC_1	1076:1080	PQTSS	SPOP	0.9754	More...
Q9UFD9	RIMS-binding protein 3A	DEG_SPOP_SBC_1	230:234	PQTSS	SPOP	0.6974	More...
A6NJZ7	RIMS-binding protein 3C	DEG_SPOP_SBC_1	230:234	PQTSS	SPOP	0.683	More...
A6NNM3	RIMS-binding protein 3B	DEG_SPOP_SBC_1	230:234	PQTSS	SPOP	0.6974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PQTSS

Degron related mutations and impact score

Drug responses associated with GATA4 mutations

All proteins holding degron of PQTSS