DegronMD - Q9P2G1(ANKIB1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P318T	TCGA-05-4396	LUAD	TCGA	PRTPRTT	DEG_SCF_FBW7_1	305:311	Mutation rewiring degron network	0.1389
p.P318T	DO23838	LUAD	ICGC	PRTPRTT	DEG_SCF_FBW7_1	305:311	Mutation rewiring degron network	0.1389
p.P1076R	TCGA-06-2566	GBM	TCGA	PQTSS	DEG_SPOP_SBC_1	1076:1080	Mutation altering degron motif	0.7512
p.P1076R	DO11507	GBM	ICGC	PQTSS	DEG_SPOP_SBC_1	1076:1080	Mutation altering degron motif	0.7512
p.M337V	TCGA-19-5956	GBM	TCGA	ISVFED	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.25
p.M337V	DO13863	GBM	ICGC	ISVFED	LIG_APCC_ABBA_1	340:345	Mutation rewiring degron network	0.25
p.S313Y	TCGA-A5-A0G2	UCEC	TCGA	PRTPRTT	DEG_SCF_FBW7_1	305:311	Mutation rewiring degron network	0.2778
p.S313Y	DO41235	UCEC	ICGC	PRTPRTT	DEG_SCF_FBW7_1	305:311	Mutation rewiring degron network	0.2778
p.R75Q	TCGA-AA-3811	COAD	TCGA	KRNVHNE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation altering degron motif	0.6218
p.R75Q	DO7962	COAD	ICGC	KRNVHNE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation altering degron motif	0.6218
p.R75Q	DO231596	LINC	ICGC	KRNVHNE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation altering degron motif	0.6218
p.S82F	TCGA-AX-A06F	UCEC	TCGA	KRNVHNE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.2778
p.S82F	DO41752	UCEC	ICGC	KRNVHNE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.2778
p.H78Y	TCGA-BG-A18B	UCEC	TCGA	KRNVHNE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation altering degron motif	0.6118
p.H78Y	DO41452	UCEC	ICGC	KRNVHNE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation altering degron motif	0.6118
p.R907W	TCGA-BH-A0B0	BRCA	TCGA	ALSSS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.2778
p.R907W	TCGA-BS-A0U7	UCEC	TCGA	ALSSS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.2778
p.R907W	TCGA-IB-7651	PAAD	TCGA	ALSSS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.2778
p.R907W	DO5333	BRCA	ICGC	ALSSS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.2778
p.R907W	DO46657	PAAD	ICGC	ALSSS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.2778
p.R907W	DO41482	UCEC	ICGC	ALSSS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.2778
p.N279S	TCGA-BR-8487	STAD	TCGA	MPTPPPS	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.0833
p.N279S	DO47867	STAD	ICGC	MPTPPPS	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.0833
p.P293S	TCGA-D1-A160	UCEC	TCGA	MPTPPPS	DEG_SCF_FBW7_1	288:294	Mutation altering degron motif	0.5641
p.P293S	DO41626	UCEC	ICGC	MPTPPPS	DEG_SCF_FBW7_1	288:294	Mutation altering degron motif	0.5641
p.P318S	TCGA-D6-6516	HNSC	TCGA	PRTPRTT	DEG_SCF_FBW7_1	305:311	Mutation rewiring degron network	0.1389
p.P318S	DO15623	HNSC	ICGC	PRTPRTT	DEG_SCF_FBW7_1	305:311	Mutation rewiring degron network	0.1389
p.P900L	TCGA-DA-A960	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.0833
p.P900L	DO219482	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.0833
p.D1070H	TCGA-E7-A7DU	BLCA	TCGA	PQTSS	DEG_SPOP_SBC_1	1076:1080	Mutation rewiring degron network	0.1667
p.D1070H	DO219016	BLCA	ICGC	PQTSS	DEG_SPOP_SBC_1	1076:1080	Mutation rewiring degron network	0.1667
p.Q1074K	TCGA-EO-A3B0	UCEC	TCGA	PQTSS	DEG_SPOP_SBC_1	1076:1080	Mutation rewiring degron network	0.2778
p.Q1074K	DO222762	COCA	ICGC	PQTSS	DEG_SPOP_SBC_1	1076:1080	Mutation rewiring degron network	0.2778
p.Q1074K	DO219773	UCEC	ICGC	PQTSS	DEG_SPOP_SBC_1	1076:1080	Mutation rewiring degron network	0.2778
p.W299C	TCGA-ER-A1A1	SKCM	TCGA	MPTPPPS	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.1944
p.W299C	TCGA-ER-A1A1	SKCM	TCGA	PRTPRTT	DEG_SCF_FBW7_1	305:311	Mutation rewiring degron network	0.1667
p.W299C	DO37413	SKCM	ICGC	MPTPPPS	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.1944
p.W299C	DO37413	SKCM	ICGC	PRTPRTT	DEG_SCF_FBW7_1	305:311	Mutation rewiring degron network	0.1667
p.S1073G	TCGA-EY-A1H0	UCEC	TCGA	PQTSS	DEG_SPOP_SBC_1	1076:1080	Mutation rewiring degron network	0.25
p.S1073G	DO43114	UCEC	ICGC	PQTSS	DEG_SPOP_SBC_1	1076:1080	Mutation rewiring degron network	0.25
p.S313F	TCGA-F7-A624	HNSC	TCGA	PRTPRTT	DEG_SCF_FBW7_1	305:311	Mutation rewiring degron network	0.2778
p.S313F	DO44440	HNSC	ICGC	PRTPRTT	DEG_SCF_FBW7_1	305:311	Mutation rewiring degron network	0.2778
p.L916V	TCGA-G2-A2ES	BLCA	TCGA	ALSSS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.25
p.L916V	DO785	BLCA	ICGC	ALSSS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.25
p.M923R	TCGA-PK-A5H8	ACC	TCGA	ALSSS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.0556
p.P900S	TCGA-WE-AAA0	SKCM	TCGA	ALSSS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.0833
p.P900S	DO51294	SKCM	ICGC	ALSSS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.0833
p.E320K	TCGA-XF-AAN2	BLCA	TCGA	PRTPRTT	DEG_SCF_FBW7_1	305:311	Mutation rewiring degron network	0.0833
p.E320K	DO219052	BLCA	ICGC	PRTPRTT	DEG_SCF_FBW7_1	305:311	Mutation rewiring degron network	0.0833
p.R283Q	DO230312	COCA	ICGC	MPTPPPS	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.1944
p.L302F	DO222842	COCA	ICGC	MPTPPPS	DEG_SCF_FBW7_1	288:294	Mutation rewiring degron network	0.1111
p.L302F	DO222842	COCA	ICGC	PRTPRTT	DEG_SCF_FBW7_1	305:311	Mutation rewiring degron network	0.25
p.D319Y	DO229028	LICA	ICGC	PRTPRTT	DEG_SCF_FBW7_1	305:311	Mutation rewiring degron network	0.1111
p.E80G	DO231596	LINC	ICGC	KRNVHNE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation altering degron motif	0.7199
p.R306G	DO23484	LINC	ICGC	PRTPRTT	DEG_SCF_FBW7_1	305:311	Mutation altering degron motif	0.6457
p.Q1077E	DO51962	PRAD	ICGC	PQTSS	DEG_SPOP_SBC_1	1076:1080	Mutation altering degron motif	0.5633
p.Q1077E	SIDM00615	Hepatocellular Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	1076:1080	Mutation altering degron motif	0.5633
p.Q1077E	SIDM00678	Bladder Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	1076:1080	Mutation altering degron motif	0.5633
p.Q1077E	SIDM00544	Neuroblastoma	GDSC	PQTSS	DEG_SPOP_SBC_1	1076:1080	Mutation altering degron motif	0.5633
p.Q1077E	SIDM00466	Ovarian Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	1076:1080	Mutation altering degron motif	0.5633
p.Q1077E	SIDM01146	Gastric Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	1076:1080	Mutation altering degron motif	0.5633
p.Q1077E	SIDM01569	Hepatocellular Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	1076:1080	Mutation altering degron motif	0.5633
p.T64I	SIDM01060	Melanoma	GDSC	KRNVHNE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.0556
p.T64I	ACH-000882	Skin Cancer	CCLE	KRNVHNE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.0556
p.T64I	IGR-1	skin	COSMIC	KRNVHNE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.0556
p.L86F	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	KRNVHNE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.1667
p.L86F	NCI-H441	lung	COSMIC	KRNVHNE	LIG_APCC_ABBAyCdc20_2	74:80	Mutation rewiring degron network	0.1667
p.E1084K	SIDM00272	Breast Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	1076:1080	Mutation rewiring degron network	0.2222
p.E1084K	MDA-MB-453	breast	COSMIC	PQTSS	DEG_SPOP_SBC_1	1076:1080	Mutation rewiring degron network	0.2222
p.T903A	SIDM01611	Endometrial Carcinoma	GDSC	ALSSS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.1667
p.T903A	ACH-000996	Endometrial/Uterine Cancer	CCLE	ALSSS	DEG_SPOP_SBC_1	909:913	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ANKIB1

UniProt ID: Q9P2G1

Entrez ID: 54467

Protein name: Ankyrin repeat and IBR domain-containing protein 1 (EC 2.3.2.31)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ANKIB1 in