DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
ISVFED
Uniprot ID:
Q9P2G1
Source protein:
Ankyrin repeat and IBR domain-containing protein 1
Source gene:
ANKIB1
Class:
LIG_APCC_ABBA_1
Location:
340:345
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.8565
ASA_SCORE:
75.5333
COIL:
0.8183
CONS_SCORE:
0.3838
DSS_SCORE:
0.0215
HELIX:
0.0667
FCONS_SCORE:
0.695
RIG_SCORE:
0.8684
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.M337V
TCGA-19-5956
GBM
TCGA
ISVFED
LIG_APCC_ABBA_1
0.25
p.M337V
DO13863
GBM
ICGC
ISVFED
LIG_APCC_ABBA_1
0.25
Drug responses associated with ANKIB1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ISVFED
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9P2G1
Ankyrin repeat and IBR domain-containing protein 1
LIG_APCC_ABBA_1
340:345
ISVFED
APC,CDC20,FZR1
0.8565
More...