DegronMD

Uniprot ID: Q9P2G1

Source protein: Ankyrin repeat and IBR domain-containing protein 1

Source gene: ANKIB1

Class: LIG_APCC_ABBAyCdc20_2

Location: 74:80

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7373

ASA_SCORE: 86.2714

COIL: 0.8504

CONS_SCORE: 0.4427

DSS_SCORE: 0.5144

HELIX: 0.0447

FCONS_SCORE: 1.1128

RIG_SCORE: 0.7043

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R75Q	TCGA-AA-3811	COAD	TCGA	KRNVHNE	LIG_APCC_ABBAyCdc20_2	0.6218
p.R75Q	DO7962	COAD	ICGC	KRNVHNE	LIG_APCC_ABBAyCdc20_2	0.6218
p.R75Q	DO231596	LINC	ICGC	KRNVHNE	LIG_APCC_ABBAyCdc20_2	0.6218
p.S82F	TCGA-AX-A06F	UCEC	TCGA	KRNVHNE	LIG_APCC_ABBAyCdc20_2	0.2778
p.S82F	DO41752	UCEC	ICGC	KRNVHNE	LIG_APCC_ABBAyCdc20_2	0.2778
p.H78Y	TCGA-BG-A18B	UCEC	TCGA	KRNVHNE	LIG_APCC_ABBAyCdc20_2	0.6118
p.H78Y	DO41452	UCEC	ICGC	KRNVHNE	LIG_APCC_ABBAyCdc20_2	0.6118
p.E80G	DO231596	LINC	ICGC	KRNVHNE	LIG_APCC_ABBAyCdc20_2	0.7199
p.T64I	SIDM01060	Melanoma	GDSC	KRNVHNE	LIG_APCC_ABBAyCdc20_2	0.0556
p.T64I	ACH-000882	Skin Cancer	CCLE	KRNVHNE	LIG_APCC_ABBAyCdc20_2	0.0556
p.T64I	IGR-1	skin	COSMIC	KRNVHNE	LIG_APCC_ABBAyCdc20_2	0.0556
p.L86F	SIDM00925	Non-Small Cell Lung Carcinoma	GDSC	KRNVHNE	LIG_APCC_ABBAyCdc20_2	0.1667
p.L86F	NCI-H441	lung	COSMIC	KRNVHNE	LIG_APCC_ABBAyCdc20_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2G1	Ankyrin repeat and IBR domain-containing protein 1	LIG_APCC_ABBAyCdc20_2	74:80	KRNVHNE	APC,CDC20,FZR1	0.7373	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons