DegronMD

Uniprot ID: Q9P2G1

Source protein: Ankyrin repeat and IBR domain-containing protein 1

Source gene: ANKIB1

Class: DEG_SCF_FBW7_1

Location: 305:311

E3 ligase: FBXW7

DEGRON score: 0.529

ASA_SCORE: 99.3143

COIL: 0.923

CONS_SCORE: 0.3862

DSS_SCORE: 0.6542

HELIX: 0.0316

FCONS_SCORE: 1.0133

RIG_SCORE: 0.6321

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P318T	TCGA-05-4396	LUAD	TCGA	PRTPRTT	DEG_SCF_FBW7_1	0.1389
p.P318T	DO23838	LUAD	ICGC	PRTPRTT	DEG_SCF_FBW7_1	0.1389
p.S313Y	TCGA-A5-A0G2	UCEC	TCGA	PRTPRTT	DEG_SCF_FBW7_1	0.2778
p.S313Y	DO41235	UCEC	ICGC	PRTPRTT	DEG_SCF_FBW7_1	0.2778
p.P318S	TCGA-D6-6516	HNSC	TCGA	PRTPRTT	DEG_SCF_FBW7_1	0.1389
p.P318S	DO15623	HNSC	ICGC	PRTPRTT	DEG_SCF_FBW7_1	0.1389
p.W299C	TCGA-ER-A1A1	SKCM	TCGA	PRTPRTT	DEG_SCF_FBW7_1	0.1667
p.W299C	DO37413	SKCM	ICGC	PRTPRTT	DEG_SCF_FBW7_1	0.1667
p.S313F	TCGA-F7-A624	HNSC	TCGA	PRTPRTT	DEG_SCF_FBW7_1	0.2778
p.S313F	DO44440	HNSC	ICGC	PRTPRTT	DEG_SCF_FBW7_1	0.2778
p.E320K	TCGA-XF-AAN2	BLCA	TCGA	PRTPRTT	DEG_SCF_FBW7_1	0.0833
p.E320K	DO219052	BLCA	ICGC	PRTPRTT	DEG_SCF_FBW7_1	0.0833
p.L302F	DO222842	COCA	ICGC	PRTPRTT	DEG_SCF_FBW7_1	0.25
p.D319Y	DO229028	LICA	ICGC	PRTPRTT	DEG_SCF_FBW7_1	0.1111
p.R306G	DO23484	LINC	ICGC	PRTPRTT	DEG_SCF_FBW7_1	0.6457

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2G1	Ankyrin repeat and IBR domain-containing protein 1	DEG_SCF_FBW7_1	305:311	PRTPRTT	FBXW7	0.529	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons