DegronMD

Uniprot ID: Q9P2G1

Source protein: Ankyrin repeat and IBR domain-containing protein 1

Source gene: ANKIB1

Class: DEG_SPOP_SBC_1

Location: 1076:1080

E3 ligase: SPOP

DEGRON score: 0.9754

ASA_SCORE: 71.8

COIL: 0.7382

CONS_SCORE: 0.3305

DSS_SCORE: 0.6471

HELIX: 0.224

FCONS_SCORE: 1.0247

RIG_SCORE: 0.6479

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1076R	TCGA-06-2566	GBM	TCGA	PQTSS	DEG_SPOP_SBC_1	0.7512
p.P1076R	DO11507	GBM	ICGC	PQTSS	DEG_SPOP_SBC_1	0.7512
p.D1070H	TCGA-E7-A7DU	BLCA	TCGA	PQTSS	DEG_SPOP_SBC_1	0.1667
p.D1070H	DO219016	BLCA	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1667
p.Q1074K	TCGA-EO-A3B0	UCEC	TCGA	PQTSS	DEG_SPOP_SBC_1	0.2778
p.Q1074K	DO222762	COCA	ICGC	PQTSS	DEG_SPOP_SBC_1	0.2778
p.Q1074K	DO219773	UCEC	ICGC	PQTSS	DEG_SPOP_SBC_1	0.2778
p.S1073G	TCGA-EY-A1H0	UCEC	TCGA	PQTSS	DEG_SPOP_SBC_1	0.25
p.S1073G	DO43114	UCEC	ICGC	PQTSS	DEG_SPOP_SBC_1	0.25
p.Q1077E	DO51962	PRAD	ICGC	PQTSS	DEG_SPOP_SBC_1	0.5633
p.Q1077E	SIDM00615	Hepatocellular Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.5633
p.Q1077E	SIDM00678	Bladder Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.5633
p.Q1077E	SIDM00544	Neuroblastoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.5633
p.Q1077E	SIDM00466	Ovarian Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.5633
p.Q1077E	SIDM01146	Gastric Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.5633
p.Q1077E	SIDM01569	Hepatocellular Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.5633
p.E1084K	SIDM00272	Breast Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.2222
p.E1084K	MDA-MB-453	breast	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95628	CCR4-NOT transcription complex subunit 4	DEG_SPOP_SBC_1	358:362	PQTSS	SPOP	0.8415	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	2173:2177	PQTSS	SPOP	0.9863	More...
P41218	Myeloid cell nuclear differentiation antigen	DEG_SPOP_SBC_1	176:180	PQTSS	SPOP	0.9954	More...
P43694	Transcription factor GATA-4	DEG_SPOP_SBC_1	418:422	PQTSS	SPOP	0.8935	More...
P52564	Dual specificity mitogen-activated protein kinase kinase 6	DEG_SPOP_SBC_1	23:27	PQTSS	SPOP	0.9755	More...
Q09472	Histone acetyltransferase p300	DEG_SPOP_SBC_1	2342:2346	PQTSS	SPOP	0.8022	More...
Q13023	A-kinase anchor protein 6	DEG_SPOP_SBC_1	2232:2236	PQTSS	SPOP	0.9624	More...
Q14118	Dystroglycan 1	DEG_SPOP_SBC_1	146:150	PQTSS	SPOP	0.8524	More...
Q14493	Histone RNA hairpin-binding protein	DEG_SPOP_SBC_1	224:228	PQTSS	SPOP	0.5108	More...
Q6K0P9	Pyrin and HIN domain-containing protein 1	DEG_SPOP_SBC_1	179:183	PQTSS	SPOP	0.9899	More...
Q6KC79	Nipped-B-like protein	DEG_SPOP_SBC_1	158:162	PQTSS	SPOP	0.9956	More...
Q6Y7W6	GRB10-interacting GYF protein 2	DEG_SPOP_SBC_1	371:375	PQTSS	SPOP	0.9311	More...
Q8IX01	SURP and G-patch domain-containing protein 2	DEG_SPOP_SBC_1	769:773	PQTSS	SPOP	0.9694	More...
Q8IYB3	Serine/arginine repetitive matrix protein 1	DEG_SPOP_SBC_1	691:695	PQTSS	SPOP	0.9405	More...
Q96N21	AP-4 complex accessory subunit Tepsin	DEG_SPOP_SBC_1	500:504	PQTSS	SPOP	0.7617	More...
Q96RT1	Erbin	DEG_SPOP_SBC_1	1214:1218	PQTSS	SPOP	0.8905	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	947:951	PQTSS	SPOP	0.7773	More...
Q9P2G1	Ankyrin repeat and IBR domain-containing protein 1	DEG_SPOP_SBC_1	1076:1080	PQTSS	SPOP	0.9754	More...
Q9UFD9	RIMS-binding protein 3A	DEG_SPOP_SBC_1	230:234	PQTSS	SPOP	0.6974	More...
A6NJZ7	RIMS-binding protein 3C	DEG_SPOP_SBC_1	230:234	PQTSS	SPOP	0.683	More...
A6NNM3	RIMS-binding protein 3B	DEG_SPOP_SBC_1	230:234	PQTSS	SPOP	0.6974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PQTSS

Degron related mutations and impact score

Drug responses associated with ANKIB1 mutations

All proteins holding degron of PQTSS