DegronMD - P52564(MAP2K6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D34Y	TCGA-05-4397	LUAD	TCGA	PQTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1389
p.D34Y	TCGA-F5-6814	READ	TCGA	PQTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1389
p.D34Y	DO25320	LUAD	ICGC	PQTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1389
p.D34Y	DO36556	READ	ICGC	PQTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1389
p.P30H	TCGA-60-2722	LUSC	TCGA	PQTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.25
p.P30H	DO26798	LUSC	ICGC	PQTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.25
p.D32V	TCGA-BH-A0HX	BRCA	TCGA	PQTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1944
p.D32V	DO5891	BRCA	ICGC	PQTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1944
p.K14T	TCGA-BS-A0UF	UCEC	TCGA	PQTSS	DEG_SPOP_SBC_1	23:27	Mutation substituting flanking lysine	0.1944
p.K14T	DO41488	UCEC	ICGC	PQTSS	DEG_SPOP_SBC_1	23:27	Mutation substituting flanking lysine	0.1944
p.M23I	DO228948	LICA	ICGC	PQTSS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.7618
p.A19S	DO228985	LICA	ICGC	PQTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.2222
p.D32Y	DO229045	LICA	ICGC	PQTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1944
p.V32A	DO228253	MALY	ICGC	PQTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1944
p.G20R	DO228338	MALY	ICGC	PQTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.25
p.G20R	DG-75	haematopoietic and lymphoid tissue	COSMIC	PQTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.25
p.P16S	DO222532	MELA	ICGC	PQTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1389
p.I15N	DO222824	MELA	ICGC	PQTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1111
p.V17M	DO46473	OV	ICGC	PQTSS	DEG_SPOP_SBC_1	23:27	Mutation substituting flanking lysine	0.2778
p.P18L	DO37406	SKCM	ICGC	PQTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.1944
p.R29P	DO40538	THCA	ICGC	PQTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.2778
p.R27Q	DO40889	UCEC	ICGC	PQTSS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.7329
p.R27Q	DO41644	UCEC	ICGC	PQTSS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.7329
p.R29Q	DO42312	UCEC	ICGC	PQTSS	DEG_SPOP_SBC_1	23:27	Mutation rewiring degron network	0.2778
p.A24V	DO41752	UCEC	ICGC	PQTSS	DEG_SPOP_SBC_1	23:27	Mutation altering degron motif	0.6936
p.T28I	SIDM00678	Bladder Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	23:27	Mutation blocking phosphorylation signal	0.75
p.T28I	HT-1376	urinary tract	COSMIC	PQTSS	DEG_SPOP_SBC_1	23:27	Mutation blocking phosphorylation signal	0.75
p.T28A	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PQTSS	DEG_SPOP_SBC_1	23:27	Mutation blocking phosphorylation signal	0.75
p.T28A	PF-382	haematopoietic and lymphoid tissue	COSMIC	PQTSS	DEG_SPOP_SBC_1	23:27	Mutation blocking phosphorylation signal	0.75

Kaplan plot for MAP2K6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAP2K6

UniProt ID: P52564

Entrez ID: 5608

Protein name: Dual specificity mitogen-activated protein kinase kinase 6 (MAP kinase kinase 6) (MAPKK 6) (EC 2.7.12.2) (MAPK/ERK kinase 6) (MEK 6) (Stress-activated protein kinase kinase 3) (SAPK kinase 3) (SAPKK-3) (SAPKK3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAP2K6 in