DegronMD

Uniprot ID: P52564

Source protein: Dual specificity mitogen-activated protein kinase kinase 6

Source gene: MAP2K6

Class: DEG_SPOP_SBC_1

Location: 23:27

E3 ligase: SPOP

DEGRON score: 0.9755

ASA_SCORE: 90.38

COIL: 0.9326

CONS_SCORE: 0.3929

DSS_SCORE: 0.7392

HELIX: 0.0382

FCONS_SCORE: 1.1016

RIG_SCORE: 0.6061

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D34Y	TCGA-05-4397	LUAD	TCGA	PQTSS	DEG_SPOP_SBC_1	0.1389
p.D34Y	TCGA-F5-6814	READ	TCGA	PQTSS	DEG_SPOP_SBC_1	0.1389
p.D34Y	DO25320	LUAD	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1389
p.D34Y	DO36556	READ	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1389
p.P30H	TCGA-60-2722	LUSC	TCGA	PQTSS	DEG_SPOP_SBC_1	0.25
p.P30H	DO26798	LUSC	ICGC	PQTSS	DEG_SPOP_SBC_1	0.25
p.D32V	TCGA-BH-A0HX	BRCA	TCGA	PQTSS	DEG_SPOP_SBC_1	0.1944
p.D32V	DO5891	BRCA	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1944
p.K14T	TCGA-BS-A0UF	UCEC	TCGA	PQTSS	DEG_SPOP_SBC_1	0.1944
p.K14T	DO41488	UCEC	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1944
p.M23I	DO228948	LICA	ICGC	PQTSS	DEG_SPOP_SBC_1	0.7618
p.A19S	DO228985	LICA	ICGC	PQTSS	DEG_SPOP_SBC_1	0.2222
p.D32Y	DO229045	LICA	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1944
p.V32A	DO228253	MALY	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1944
p.G20R	DO228338	MALY	ICGC	PQTSS	DEG_SPOP_SBC_1	0.25
p.G20R	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.25
p.P16S	DO222532	MELA	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1389
p.I15N	DO222824	MELA	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1111
p.V17M	DO46473	OV	ICGC	PQTSS	DEG_SPOP_SBC_1	0.2778
p.P18L	DO37406	SKCM	ICGC	PQTSS	DEG_SPOP_SBC_1	0.1944
p.R29P	DO40538	THCA	ICGC	PQTSS	DEG_SPOP_SBC_1	0.2778
p.R27Q	DO40889	UCEC	ICGC	PQTSS	DEG_SPOP_SBC_1	0.7329
p.R27Q	DO41644	UCEC	ICGC	PQTSS	DEG_SPOP_SBC_1	0.7329
p.R29Q	DO42312	UCEC	ICGC	PQTSS	DEG_SPOP_SBC_1	0.2778
p.A24V	DO41752	UCEC	ICGC	PQTSS	DEG_SPOP_SBC_1	0.6936
p.T28I	SIDM00678	Bladder Carcinoma	GDSC	PQTSS	DEG_SPOP_SBC_1	0.75
p.T28I	HT-1376	urinary_tract	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.75
p.T28A	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PQTSS	DEG_SPOP_SBC_1	0.75
p.T28A	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	PQTSS	DEG_SPOP_SBC_1	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95628	CCR4-NOT transcription complex subunit 4	DEG_SPOP_SBC_1	358:362	PQTSS	SPOP	0.8415	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	2173:2177	PQTSS	SPOP	0.9863	More...
P41218	Myeloid cell nuclear differentiation antigen	DEG_SPOP_SBC_1	176:180	PQTSS	SPOP	0.9954	More...
P43694	Transcription factor GATA-4	DEG_SPOP_SBC_1	418:422	PQTSS	SPOP	0.8935	More...
P52564	Dual specificity mitogen-activated protein kinase kinase 6	DEG_SPOP_SBC_1	23:27	PQTSS	SPOP	0.9755	More...
Q09472	Histone acetyltransferase p300	DEG_SPOP_SBC_1	2342:2346	PQTSS	SPOP	0.8022	More...
Q13023	A-kinase anchor protein 6	DEG_SPOP_SBC_1	2232:2236	PQTSS	SPOP	0.9624	More...
Q14118	Dystroglycan 1	DEG_SPOP_SBC_1	146:150	PQTSS	SPOP	0.8524	More...
Q14493	Histone RNA hairpin-binding protein	DEG_SPOP_SBC_1	224:228	PQTSS	SPOP	0.5108	More...
Q6K0P9	Pyrin and HIN domain-containing protein 1	DEG_SPOP_SBC_1	179:183	PQTSS	SPOP	0.9899	More...
Q6KC79	Nipped-B-like protein	DEG_SPOP_SBC_1	158:162	PQTSS	SPOP	0.9956	More...
Q6Y7W6	GRB10-interacting GYF protein 2	DEG_SPOP_SBC_1	371:375	PQTSS	SPOP	0.9311	More...
Q8IX01	SURP and G-patch domain-containing protein 2	DEG_SPOP_SBC_1	769:773	PQTSS	SPOP	0.9694	More...
Q8IYB3	Serine/arginine repetitive matrix protein 1	DEG_SPOP_SBC_1	691:695	PQTSS	SPOP	0.9405	More...
Q96N21	AP-4 complex accessory subunit Tepsin	DEG_SPOP_SBC_1	500:504	PQTSS	SPOP	0.7617	More...
Q96RT1	Erbin	DEG_SPOP_SBC_1	1214:1218	PQTSS	SPOP	0.8905	More...
Q9H2D6	TRIO and F-actin-binding protein	DEG_SPOP_SBC_1	947:951	PQTSS	SPOP	0.7773	More...
Q9P2G1	Ankyrin repeat and IBR domain-containing protein 1	DEG_SPOP_SBC_1	1076:1080	PQTSS	SPOP	0.9754	More...
Q9UFD9	RIMS-binding protein 3A	DEG_SPOP_SBC_1	230:234	PQTSS	SPOP	0.6974	More...
A6NJZ7	RIMS-binding protein 3C	DEG_SPOP_SBC_1	230:234	PQTSS	SPOP	0.683	More...
A6NNM3	RIMS-binding protein 3B	DEG_SPOP_SBC_1	230:234	PQTSS	SPOP	0.6974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PQTSS

Degron related mutations and impact score

Drug responses associated with MAP2K6 mutations

All proteins holding degron of PQTSS