DegronMD - O95628(CNOT4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G559V	TCGA-46-3769	LUSC	TCGA	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.2778
p.A322T	TCGA-5M-AAT6	COAD	TCGA	PISSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2222
p.A322T	DO223703	COAD	ICGC	PISSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2222
p.G559W	TCGA-60-2719	LUSC	TCGA	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.2778
p.G559W	DO27453	LUSC	ICGC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.2778
p.P365L	TCGA-66-2794	LUSC	TCGA	PQTSS	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.25
p.P365L	DO26683	LUSC	ICGC	PQTSS	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.25
p.S546R	TCGA-71-6725	LUAD	TCGA	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1389
p.S546R	DO23699	LUAD	ICGC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1389
p.N319T	TCGA-AX-A05Z	UCEC	TCGA	PISSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.3056
p.N319T	DO40884	UCEC	ICGC	PISSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.3056
p.G328W	TCGA-AX-A1CE	UCEC	TCGA	PISSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.0556
p.G328W	DO42280	UCEC	ICGC	PISSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.0556
p.T375A	TCGA-CJ-4907	KIRC	TCGA	PVSSS	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.1944
p.T375A	DO19743	KIRC	ICGC	PVSSS	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.1944
p.S376L	TCGA-D3-A3C1	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.2222
p.S376L	DO47323	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.2222
p.S547P	TCGA-DU-A5TP	LGG	TCGA	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1667
p.P314S	TCGA-EE-A20B	SKCM	TCGA	PISSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.6752
p.P314S	DO37547	SKCM	ICGC	PISSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.6752
p.S550L	DO222955	BTCA	ICGC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.25
p.S550L	DO41542	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.25
p.S372I	DO227996	COCA	ICGC	PQTSS	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.0556
p.S372I	DO227996	COCA	ICGC	PVSSS	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.1111
p.G556V	DO222769	COCA	ICGC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation altering degron motif	0.7532
p.G556V	DO26590	LUSC	ICGC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation altering degron motif	0.7532
p.V545I	DO229010	COCA	ICGC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1111
p.V545I	DO229013	COCA	ICGC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1111
p.V545I	DO229016	COCA	ICGC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1111
p.V545I	DO229003	COCA	ICGC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1111
p.V545I	DO229005	COCA	ICGC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1111
p.V545I	DO228941	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1111
p.P348L	DO234462	ESAD	ICGC	PQTSS	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.0556
p.L564P	DO223010	ESCA	ICGC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1389
p.S544P	DO44562	LGG	ICGC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.0833
p.L548F	DO231992	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation substituting flanking lysine	0.3056
p.W560C	DO228405	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.25
p.W560S	DO228405	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.25
p.Q562K	DO228985	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1944
p.Q562K	DO229022	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1944
p.P558Q	DO229018	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.3056
p.H559Q	DO229025	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.2778
p.V549F	DO229052	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.2222
p.S372R	DO229009	LICA	ICGC	PQTSS	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.0556
p.S372R	DO229009	LICA	ICGC	PVSSS	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.1111
p.S551G	DO22857	LIHC	ICGC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.2778
p.E552Q	DO23192	LINC	ICGC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.3056
p.P314L	DO220891	MELA	ICGC	PISSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.7582
p.E544K	DO220896	MELA	ICGC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.0833
p.A566V	DO47255	SKCM	ICGC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.0833
p.S563F	DO47303	SKCM	ICGC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1667
p.A543S	DO229242	THCA	ICGC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.0556
p.K548N	DO43186	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation substituting flanking lysine	0.3056
p.P553T	DO52402	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation altering degron motif	0.7031
p.N552H	SIDM01043	Other Sarcomas	GDSC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.3056
p.N552H	ESS-1	endometrium	COSMIC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.3056
p.S545N	SIDM00845	Burkitt's Lymphoma	GDSC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1111
p.S545N	SIDM00461	Acute Myeloid Leukemia	GDSC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1111
p.S545N	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1111
p.S545N	SIDM01519	Head and Neck Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1111
p.S545N	DND-41	haematopoietic and lymphoid tissue	COSMIC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1111
p.S545N	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.1111
p.T556A	SIDM00845	Burkitt's Lymphoma	GDSC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation altering degron motif	0.7139
p.T556A	SIDM00461	Acute Myeloid Leukemia	GDSC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation altering degron motif	0.7139
p.T556A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation altering degron motif	0.7139
p.T556A	SIDM01519	Head and Neck Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation altering degron motif	0.7139
p.T556A	ACH-000037	Sarcoma	CCLE	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation altering degron motif	0.7139
p.T556A	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation altering degron motif	0.7139
p.T556A	DND-41	haematopoietic and lymphoid tissue	COSMIC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation altering degron motif	0.7139
p.T556A	Daudi	haematopoietic and lymphoid tissue	COSMIC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation altering degron motif	0.7139
p.S321I	SIDM01090	Colorectal Carcinoma	GDSC	PISSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.25
p.S321I	RKO	large intestine	COSMIC	PISSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.25
p.S321C	SIDM01090	Colorectal Carcinoma	GDSC	PISSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.25
p.S321C	RKO	large intestine	COSMIC	PISSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.25
p.R323Q	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PISSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1944
p.R323Q	SIDM00153	T-Lymphoblastic Leukemia	GDSC	PISSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1944
p.R323Q	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PISSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.1944
p.I313M	SIDM01089	B-Cell Non-Hodgkin's Lymphoma	GDSC	PISSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.3056
p.I313M	RL	haematopoietic and lymphoid tissue	COSMIC	PISSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.3056
p.T375K	SIDM01735	Biliary Tract Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.1944
p.S317L	SIDM01776	Plasma Cell Myeloma	GDSC	PISSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.8778
p.L373F	SIDM01768	Melanoma	GDSC	PVSSS	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.1389
p.I310M	ACH-000371	Lymphoma	CCLE	PISSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2222
p.I310M	RL	haematopoietic and lymphoid tissue	COSMIC	PISSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2222
p.S314L	ACH-000774	Lung Cancer	CCLE	PISSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.7667
p.S314L	ACH-001162	Myeloma	CCLE	PISSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.7667
p.T372K	ACH-000808	Bile Duct Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.0556
p.T372K	ACH-000808	Bile Duct Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.1111
p.L370F	ACH-000899	Skin Cancer	CCLE	PQTSS	DEG_SPOP_SBC_1	358:362	Mutation rewiring degron network	0.1111
p.L370F	ACH-000899	Skin Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	380:384	Mutation rewiring degron network	0.0556
p.N549H	ACH-000913	Endometrial/Uterine Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.2222
p.N549H	ESS-1	endometrium	COSMIC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation rewiring degron network	0.2222
p.S318I	ACH-000943	Colon/Colorectal Cancer	CCLE	PISSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.7341
p.S318I	RKO	large intestine	COSMIC	PISSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.7341
p.S318C	ACH-000943	Colon/Colorectal Cancer	CCLE	PISSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.7541
p.S318C	RKO	large intestine	COSMIC	PISSS	DEG_SPOP_SBC_1	314:318	Mutation altering degron motif	0.7541
p.R320Q	ACH-000964	Leukemia	CCLE	PISSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2778
p.R320Q	ACH-001127	Leukemia	CCLE	PISSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2778
p.R320Q	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PISSS	DEG_SPOP_SBC_1	314:318	Mutation rewiring degron network	0.2778
p.T553A	DND-41	haematopoietic and lymphoid tissue	COSMIC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation altering degron motif	0.7139
p.T553A	Daudi	haematopoietic and lymphoid tissue	COSMIC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation altering degron motif	0.7139
p.T553A	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PLSTS	DEG_SPOP_SBC_1	553:557	Mutation altering degron motif	0.7139

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CNOT4

UniProt ID: O95628

Entrez ID: 4850

Protein name: CCR4-NOT transcription complex subunit 4 (EC 2.3.2.27) (CCR4-associated factor 4) (E3 ubiquitin-protein ligase CNOT4) (Potential transcriptional repressor NOT4Hp) (RING-type E3 ubiquitin transferase CNOT4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CNOT4 in