DegronMD

Uniprot ID: O95628

Source protein: CCR4-NOT transcription complex subunit 4

Source gene: CNOT4

Class: DEG_SPOP_SBC_1

Location: 553:557

E3 ligase: SPOP

DEGRON score: 0.8233

ASA_SCORE: 84.3

COIL: 0.9084

CONS_SCORE: 0.3204

DSS_SCORE: 0.6253

HELIX: 0.0508

FCONS_SCORE: 1.0478

RIG_SCORE: 0.6629

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G559V	TCGA-46-3769	LUSC	TCGA	PLSTS	DEG_SPOP_SBC_1	0.2778
p.G559W	TCGA-60-2719	LUSC	TCGA	PLSTS	DEG_SPOP_SBC_1	0.2778
p.G559W	DO27453	LUSC	ICGC	PLSTS	DEG_SPOP_SBC_1	0.2778
p.S546R	TCGA-71-6725	LUAD	TCGA	PLSTS	DEG_SPOP_SBC_1	0.1389
p.S546R	DO23699	LUAD	ICGC	PLSTS	DEG_SPOP_SBC_1	0.1389
p.S547P	TCGA-DU-A5TP	LGG	TCGA	PLSTS	DEG_SPOP_SBC_1	0.1667
p.S550L	DO222955	BTCA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.25
p.S550L	DO41542	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	0.25
p.G556V	DO222769	COCA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.7532
p.G556V	DO26590	LUSC	ICGC	PLSTS	DEG_SPOP_SBC_1	0.7532
p.V545I	DO229010	COCA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.1111
p.V545I	DO229013	COCA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.1111
p.V545I	DO229016	COCA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.1111
p.V545I	DO229003	COCA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.1111
p.V545I	DO229005	COCA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.1111
p.V545I	DO228941	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.1111
p.L564P	DO223010	ESCA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.1389
p.S544P	DO44562	LGG	ICGC	PLSTS	DEG_SPOP_SBC_1	0.0833
p.L548F	DO231992	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.3056
p.W560C	DO228405	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.25
p.W560S	DO228405	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.25
p.Q562K	DO228985	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.1944
p.Q562K	DO229022	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.1944
p.P558Q	DO229018	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.3056
p.H559Q	DO229025	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.2778
p.V549F	DO229052	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.2222
p.S551G	DO22857	LIHC	ICGC	PLSTS	DEG_SPOP_SBC_1	0.2778
p.E552Q	DO23192	LINC	ICGC	PLSTS	DEG_SPOP_SBC_1	0.3056
p.E544K	DO220896	MELA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.0833
p.A566V	DO47255	SKCM	ICGC	PLSTS	DEG_SPOP_SBC_1	0.0833
p.S563F	DO47303	SKCM	ICGC	PLSTS	DEG_SPOP_SBC_1	0.1667
p.A543S	DO229242	THCA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.0556
p.K548N	DO43186	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	0.3056
p.P553T	DO52402	UCEC	ICGC	PLSTS	DEG_SPOP_SBC_1	0.7031
p.N552H	SIDM01043	Other Sarcomas	GDSC	PLSTS	DEG_SPOP_SBC_1	0.3056
p.N552H	ESS-1	endometrium	COSMIC	PLSTS	DEG_SPOP_SBC_1	0.3056
p.S545N	SIDM00845	Burkitt's Lymphoma	GDSC	PLSTS	DEG_SPOP_SBC_1	0.1111
p.S545N	SIDM00461	Acute Myeloid Leukemia	GDSC	PLSTS	DEG_SPOP_SBC_1	0.1111
p.S545N	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PLSTS	DEG_SPOP_SBC_1	0.1111
p.S545N	SIDM01519	Head and Neck Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	0.1111
p.S545N	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PLSTS	DEG_SPOP_SBC_1	0.1111
p.S545N	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PLSTS	DEG_SPOP_SBC_1	0.1111
p.T556A	SIDM00845	Burkitt's Lymphoma	GDSC	PLSTS	DEG_SPOP_SBC_1	0.7139
p.T556A	SIDM00461	Acute Myeloid Leukemia	GDSC	PLSTS	DEG_SPOP_SBC_1	0.7139
p.T556A	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PLSTS	DEG_SPOP_SBC_1	0.7139
p.T556A	SIDM01519	Head and Neck Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	0.7139
p.T556A	ACH-000037	Sarcoma	CCLE	PLSTS	DEG_SPOP_SBC_1	0.7139
p.T556A	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PLSTS	DEG_SPOP_SBC_1	0.7139
p.T556A	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PLSTS	DEG_SPOP_SBC_1	0.7139
p.T556A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PLSTS	DEG_SPOP_SBC_1	0.7139
p.N549H	ACH-000913	Endometrial/Uterine Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	0.2222
p.N549H	ESS-1	endometrium	COSMIC	PLSTS	DEG_SPOP_SBC_1	0.2222
p.T553A	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PLSTS	DEG_SPOP_SBC_1	0.7139
p.T553A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PLSTS	DEG_SPOP_SBC_1	0.7139
p.T553A	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	PLSTS	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00167	Eyes absent homolog 2	DEG_SPOP_SBC_1	196:200	PLSTS	SPOP	0.8269	More...
O95628	CCR4-NOT transcription complex subunit 4	DEG_SPOP_SBC_1	553:557	PLSTS	SPOP	0.8233	More...
P28562	Dual specificity protein phosphatase 1	DEG_SPOP_SBC_1	148:152	PLSTS	SPOP	0.9304	More...
Q53TQ3	INO80 complex subunit D	DEG_SPOP_SBC_1	214:218	PLSTS	SPOP	0.9858	More...
Q5THR3	EF-hand calcium-binding domain-containing protein 6	DEG_SPOP_SBC_1	119:123	PLSTS	SPOP	0.6545	More...
Q5XPI4	E3 ubiquitin-protein ligase RNF123	DEG_SPOP_SBC_1	698:702	PLSTS	SPOP	0.9944	More...
Q6UXF1	Transmembrane protein 108	DEG_SPOP_SBC_1	345:349	PLSTS	SPOP	0.979	More...
Q70CQ3	Ubiquitin carboxyl-terminal hydrolase 30	DEG_SPOP_SBC_1	466:470	PLSTS	SPOP	0.5113	More...
Q86UK5	Limbin	DEG_SPOP_SBC_1	112:116	PLSTS	SPOP	0.7993	More...
Q86Y82	Syntaxin-12	DEG_SPOP_SBC_1	90:94	PLSTS	SPOP	0.702	More...
Q8IY33	MICAL-like protein 2	DEG_SPOP_SBC_1	519:523	PLSTS	SPOP	0.9828	More...
Q8IY92	Structure-specific endonuclease subunit SLX4	DEG_SPOP_SBC_1	1448:1452	PLSTS	SPOP	0.9903	More...
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_SPOP_SBC_1	2661:2665	PLSTS	SPOP	0.8392	More...
Q8TEQ6	Gem-associated protein 5	DEG_SPOP_SBC_1	850:854	PLSTS	SPOP	0.9922	More...
Q96KQ4	Apoptosis-stimulating of p53 protein 1	DEG_SPOP_SBC_1	336:340	PLSTS	SPOP	0.9301	More...
Q96Q89	Kinesin-like protein KIF20B	DEG_SPOP_SBC_1	1584:1588	PLSTS	SPOP	0.9863	More...
Q99490	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2	DEG_SPOP_SBC_1	1046:1050	PLSTS	SPOP	0.6945	More...
Q99570	Phosphoinositide 3-kinase regulatory subunit 4	DEG_SPOP_SBC_1	901:905	PLSTS	SPOP	0.9634	More...
Q9H2E6	Semaphorin-6A	DEG_SPOP_SBC_1	1018:1022	PLSTS	SPOP	0.9889	More...
Q9H706	GRB2-associated and regulator of MAPK protein 1	DEG_SPOP_SBC_1	542:546	PLSTS	SPOP	0.9196	More...
Q9HBL0	Tensin-1	DEG_SPOP_SBC_1	1075:1079	PLSTS	SPOP	0.9851	More...
Q9UBP5	Hairy/enhancer-of-split related with YRPW motif protein 2	DEG_SPOP_SBC_1	252:256	PLSTS	SPOP	0.7183	More...
Q6ZUB1	Spermatogenesis-associated protein 31E1	DEG_SPOP_SBC_1	1149:1153	PLSTS	SPOP	0.9944	More...
Q96HE9	Proline-rich protein 11	DEG_SPOP_SBC_1	350:354	PLSTS	SPOP	0.9951	More...
Q6ZU67	BEN domain-containing protein 4	DEG_SPOP_SBC_1	281:285	PLSTS	SPOP	0.8233	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	1617:1621	PLSTS	SPOP	0.5245	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLSTS

Degron related mutations and impact score

Drug responses associated with CNOT4 mutations

All proteins holding degron of PLSTS