DegronMD - O00167(EYA2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E206Q	TCGA-17-Z026	LUAD	TCGA	PLSTS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1667
p.A244D	TCGA-44-7670	LUAD	TCGA	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.0833
p.A244D	DO23555	LUAD	ICGC	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.0833
p.D237V	TCGA-A1-A0SO	BRCA	TCGA	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.2778
p.D237V	DO2020	BRCA	ICGC	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.2778
p.V187I	TCGA-AN-A0XN	BRCA	TCGA	PLSTS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.0833
p.V187I	TCGA-VQ-A91K	STAD	TCGA	PLSTS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.0833
p.V187I	DO3745	BRCA	ICGC	PLSTS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.0833
p.V187I	DO51785	STAD	ICGC	PLSTS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.0833
p.P194T	TCGA-B0-5699	KIRC	TCGA	PLSTS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.2778
p.P194T	DO16486	KIRC	ICGC	PLSTS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.2778
p.R240K	TCGA-BF-A5EQ	SKCM	TCGA	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.1944
p.R240K	TCGA-BF-AAP2	SKCM	TCGA	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.1944
p.R240K	DO219466	SKCM	ICGC	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.1944
p.R240K	DO219452	SKCM	ICGC	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.1944
p.E222K	TCGA-EE-A29S	SKCM	TCGA	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.1389
p.E222K	DO37936	SKCM	ICGC	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.1389
p.G228E	TCGA-EO-A22R	UCEC	TCGA	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.3056
p.G228E	DO42713	UCEC	ICGC	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.3056
p.S230F	TCGA-FD-A6TH	BLCA	TCGA	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation altering degron motif	0.6871
p.S230F	DO49763	BLCA	ICGC	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation altering degron motif	0.6871
p.S195L	TCGA-HU-8602	STAD	TCGA	PLSTS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.3056
p.S195L	DO47829	STAD	ICGC	PLSTS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.3056
p.P241L	DO218693	GACA	ICGC	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.1667
p.R243Q	DO218673	GACA	ICGC	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.1111
p.R243Q	SIDM00179	Melanoma	GDSC	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.1111
p.R243Q	MZ2-MEL	skin	COSMIC	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.1111
p.G221C	DO229022	LICA	ICGC	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.1111
p.T238R	DO45299	LIRI	ICGC	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.25
p.T238A	SIDM01090	Colorectal Carcinoma	GDSC	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.25
p.T238A	SIDM01112	Osteosarcoma	GDSC	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.25
p.T238A	SIDM00995	Other Solid Cancers	GDSC	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.25
p.T238A	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.25
p.T238A	SIDM00934	Pancreatic Carcinoma	GDSC	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.25
p.T238A	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.25
p.T238A	SIDM00493	Other Solid Cancers	GDSC	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.25
p.T238A	SIDM00483	Esophageal Carcinoma	GDSC	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.25
p.T238A	SIDM00097	Breast Carcinoma	GDSC	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.25
p.T238A	SIDM00068	Colorectal Carcinoma	GDSC	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.25
p.T238A	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.25
p.P188S	SIDM00695	Melanoma	GDSC	PLSTS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1111
p.P188S	ACH-000322	Skin Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1111
p.P188S	ACH-002458	Skin Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1111
p.P188S	ACH-002459	Skin Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1111
p.P188S	ACH-002460	Skin Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1111
p.P188S	HT-144	skin	COSMIC	PLSTS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1111
p.P188L	SIDM00332	Breast Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1111
p.P188L	MFM-223	breast	COSMIC	PLSTS	DEG_SPOP_SBC_1	196:200	Mutation rewiring degron network	0.1111
p.A233V	SIDM01617	Endometrial Carcinoma	GDSC	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation altering degron motif	0.5825
p.A233V	ACH-000994	Endometrial/Uterine Cancer	CCLE	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation altering degron motif	0.5825
p.R243W	SIDM01725	Non-Cancerous	GDSC	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.1111
p.R228Q	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.3056
p.D240G	EBC-1	lung	COSMIC	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.1944
p.R219Q	MZ2-MEL	skin	COSMIC	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.0556
p.G239E	SK-MEL-30	skin	COSMIC	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.2222
p.D222N	C-33-A	cervix	COSMIC	PSTPAKE	DEG_SCF_FBW7_2	229:235	Mutation rewiring degron network	0.1389

Kaplan plot for EYA2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EYA2

UniProt ID: O00167

Entrez ID: 2139

Protein name: Eyes absent homolog 2 (EC 3.1.3.48)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EYA2 in