DegronMD

Uniprot ID: O00167

Source protein: Eyes absent homolog 2

Source gene: EYA2

Class: DEG_SCF_FBW7_2

Location: 229:235

E3 ligase: FBXW7

DEGRON score: 0.9789

ASA_SCORE: 83.9286

COIL: 0.9327

CONS_SCORE: 0.3946

DSS_SCORE: 0.8204

HELIX: 0.041

FCONS_SCORE: 1.1187

RIG_SCORE: 0.5328

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A244D	TCGA-44-7670	LUAD	TCGA	PSTPAKE	DEG_SCF_FBW7_2	0.0833
p.A244D	DO23555	LUAD	ICGC	PSTPAKE	DEG_SCF_FBW7_2	0.0833
p.D237V	TCGA-A1-A0SO	BRCA	TCGA	PSTPAKE	DEG_SCF_FBW7_2	0.2778
p.D237V	DO2020	BRCA	ICGC	PSTPAKE	DEG_SCF_FBW7_2	0.2778
p.R240K	TCGA-BF-A5EQ	SKCM	TCGA	PSTPAKE	DEG_SCF_FBW7_2	0.1944
p.R240K	TCGA-BF-AAP2	SKCM	TCGA	PSTPAKE	DEG_SCF_FBW7_2	0.1944
p.R240K	DO219466	SKCM	ICGC	PSTPAKE	DEG_SCF_FBW7_2	0.1944
p.R240K	DO219452	SKCM	ICGC	PSTPAKE	DEG_SCF_FBW7_2	0.1944
p.E222K	TCGA-EE-A29S	SKCM	TCGA	PSTPAKE	DEG_SCF_FBW7_2	0.1389
p.E222K	DO37936	SKCM	ICGC	PSTPAKE	DEG_SCF_FBW7_2	0.1389
p.G228E	TCGA-EO-A22R	UCEC	TCGA	PSTPAKE	DEG_SCF_FBW7_2	0.3056
p.G228E	DO42713	UCEC	ICGC	PSTPAKE	DEG_SCF_FBW7_2	0.3056
p.S230F	TCGA-FD-A6TH	BLCA	TCGA	PSTPAKE	DEG_SCF_FBW7_2	0.6871
p.S230F	DO49763	BLCA	ICGC	PSTPAKE	DEG_SCF_FBW7_2	0.6871
p.P241L	DO218693	GACA	ICGC	PSTPAKE	DEG_SCF_FBW7_2	0.1667
p.R243Q	DO218673	GACA	ICGC	PSTPAKE	DEG_SCF_FBW7_2	0.1111
p.R243Q	SIDM00179	Melanoma	GDSC	PSTPAKE	DEG_SCF_FBW7_2	0.1111
p.R243Q	MZ2-MEL	skin	COSMIC	PSTPAKE	DEG_SCF_FBW7_2	0.1111
p.G221C	DO229022	LICA	ICGC	PSTPAKE	DEG_SCF_FBW7_2	0.1111
p.T238R	DO45299	LIRI	ICGC	PSTPAKE	DEG_SCF_FBW7_2	0.25
p.T238A	SIDM01090	Colorectal Carcinoma	GDSC	PSTPAKE	DEG_SCF_FBW7_2	0.25
p.T238A	SIDM01112	Osteosarcoma	GDSC	PSTPAKE	DEG_SCF_FBW7_2	0.25
p.T238A	SIDM00995	Other Solid Cancers	GDSC	PSTPAKE	DEG_SCF_FBW7_2	0.25
p.T238A	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PSTPAKE	DEG_SCF_FBW7_2	0.25
p.T238A	SIDM00934	Pancreatic Carcinoma	GDSC	PSTPAKE	DEG_SCF_FBW7_2	0.25
p.T238A	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PSTPAKE	DEG_SCF_FBW7_2	0.25
p.T238A	SIDM00493	Other Solid Cancers	GDSC	PSTPAKE	DEG_SCF_FBW7_2	0.25
p.T238A	SIDM00483	Esophageal Carcinoma	GDSC	PSTPAKE	DEG_SCF_FBW7_2	0.25
p.T238A	SIDM00097	Breast Carcinoma	GDSC	PSTPAKE	DEG_SCF_FBW7_2	0.25
p.T238A	SIDM00068	Colorectal Carcinoma	GDSC	PSTPAKE	DEG_SCF_FBW7_2	0.25
p.T238A	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PSTPAKE	DEG_SCF_FBW7_2	0.25
p.A233V	SIDM01617	Endometrial Carcinoma	GDSC	PSTPAKE	DEG_SCF_FBW7_2	0.5825
p.A233V	ACH-000994	Endometrial/Uterine Cancer	CCLE	PSTPAKE	DEG_SCF_FBW7_2	0.5825
p.R243W	SIDM01725	Non-Cancerous	GDSC	PSTPAKE	DEG_SCF_FBW7_2	0.1111
p.R228Q	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	PSTPAKE	DEG_SCF_FBW7_2	0.3056
p.D240G	EBC-1	lung	COSMIC	PSTPAKE	DEG_SCF_FBW7_2	0.1944
p.R219Q	MZ2-MEL	skin	COSMIC	PSTPAKE	DEG_SCF_FBW7_2	0.0556
p.G239E	SK-MEL-30	skin	COSMIC	PSTPAKE	DEG_SCF_FBW7_2	0.2222
p.D222N	C-33-A	cervix	COSMIC	PSTPAKE	DEG_SCF_FBW7_2	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSTPAKE

Degron related mutations and impact score

Drug responses associated with EYA2 mutations

All proteins holding degron of PSTPAKE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00167	Eyes absent homolog 2	DEG_SCF_FBW7_2	229:235	PSTPAKE	FBXW7	0.9789	More...