DegronMD

Uniprot ID: Q8IY33

Source protein: MICAL-like protein 2

Source gene: MICALL2

Class: DEG_SPOP_SBC_1

Location: 519:523

E3 ligase: SPOP

DEGRON score: 0.9828

ASA_SCORE: 86.04

COIL: 0.918

CONS_SCORE: 0.3638

DSS_SCORE: 0.7162

HELIX: 0.0554

FCONS_SCORE: 1.1281

RIG_SCORE: 0.5795

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S529Y	TCGA-CR-7374	HNSC	TCGA	PLSTS	DEG_SPOP_SBC_1	0.1667
p.S529Y	DO15334	HNSC	ICGC	PLSTS	DEG_SPOP_SBC_1	0.1667
p.S512L	TCGA-D3-A1Q8	SKCM	TCGA	PLSTS	DEG_SPOP_SBC_1	0.1389
p.S512L	DO37446	SKCM	ICGC	PLSTS	DEG_SPOP_SBC_1	0.1389
p.S512L	SIDM01175	Other Sarcomas	GDSC	PLSTS	DEG_SPOP_SBC_1	0.1389
p.S512L	ACH-002309	Sarcoma	CCLE	PLSTS	DEG_SPOP_SBC_1	0.1389
p.S512L	SW684	soft_tissue	COSMIC	PLSTS	DEG_SPOP_SBC_1	0.1389
p.Q527E	TCGA-GC-A3I6	BLCA	TCGA	PLSTS	DEG_SPOP_SBC_1	0.2222
p.Q527E	DO844	BLCA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.2222
p.A528T	TCGA-XK-AAIW	PRAD	TCGA	PLSTS	DEG_SPOP_SBC_1	0.1944
p.A528T	DO51407	PRAD	ICGC	PLSTS	DEG_SPOP_SBC_1	0.1944
p.S523N	DO223583	CLLE	ICGC	PLSTS	DEG_SPOP_SBC_1	0.7069
p.T522K	DO229028	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.7306
p.Q527K	DO229035	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.2222
p.Q527H	DO222708	MELA	ICGC	PLSTS	DEG_SPOP_SBC_1	0.2222
p.P519L	SIDM00773	Non-Cancerous	GDSC	PLSTS	DEG_SPOP_SBC_1	0.7582
p.P519L	SIDM00454	Rhabdomyosarcoma	GDSC	PLSTS	DEG_SPOP_SBC_1	0.7582
p.P519L	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	0.7582
p.P519L	SIDM01112	Osteosarcoma	GDSC	PLSTS	DEG_SPOP_SBC_1	0.7582
p.P519L	SIDM01099	Neuroblastoma	GDSC	PLSTS	DEG_SPOP_SBC_1	0.7582
p.P519L	SIDM00694	Other Solid Cancers	GDSC	PLSTS	DEG_SPOP_SBC_1	0.7582
p.P519L	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	0.7582
p.P519L	SIDM00254	Neuroblastoma	GDSC	PLSTS	DEG_SPOP_SBC_1	0.7582
p.P519L	SIDM00539	Esophageal Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	0.7582
p.P519L	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	0.7582
p.P519L	SIDM00774	Breast Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	0.7582
p.P519L	SIDM01525	Acute Myeloid Leukemia	GDSC	PLSTS	DEG_SPOP_SBC_1	0.7582
p.S524T	SIDM01144	Gastric Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	0.3056
p.S524T	SIDM01194	Hepatocellular Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	0.3056
p.S524T	SIDM00192	Colorectal Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	0.3056
p.S524T	SIDM01569	Hepatocellular Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	0.3056
p.S524T	SNU-449	liver	COSMIC	PLSTS	DEG_SPOP_SBC_1	0.3056
p.S524T	NCI-SNU-5	stomach	COSMIC	PLSTS	DEG_SPOP_SBC_1	0.3056
p.T525I	SIDM00382	Glioblastoma	GDSC	PLSTS	DEG_SPOP_SBC_1	0.2778
p.T525I	ACH-000609	Brain Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	0.2778
p.T525I	SF126	central_nervous_system	COSMIC	PLSTS	DEG_SPOP_SBC_1	0.2778
p.S521N	SIDM01617	Endometrial Carcinoma	GDSC	PLSTS	DEG_SPOP_SBC_1	0.7069
p.S521N	ACH-000994	Endometrial/Uterine Cancer	CCLE	PLSTS	DEG_SPOP_SBC_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00167	Eyes absent homolog 2	DEG_SPOP_SBC_1	196:200	PLSTS	SPOP	0.8269	More...
O95628	CCR4-NOT transcription complex subunit 4	DEG_SPOP_SBC_1	553:557	PLSTS	SPOP	0.8233	More...
P28562	Dual specificity protein phosphatase 1	DEG_SPOP_SBC_1	148:152	PLSTS	SPOP	0.9304	More...
Q53TQ3	INO80 complex subunit D	DEG_SPOP_SBC_1	214:218	PLSTS	SPOP	0.9858	More...
Q5THR3	EF-hand calcium-binding domain-containing protein 6	DEG_SPOP_SBC_1	119:123	PLSTS	SPOP	0.6545	More...
Q5XPI4	E3 ubiquitin-protein ligase RNF123	DEG_SPOP_SBC_1	698:702	PLSTS	SPOP	0.9944	More...
Q6UXF1	Transmembrane protein 108	DEG_SPOP_SBC_1	345:349	PLSTS	SPOP	0.979	More...
Q70CQ3	Ubiquitin carboxyl-terminal hydrolase 30	DEG_SPOP_SBC_1	466:470	PLSTS	SPOP	0.5113	More...
Q86UK5	Limbin	DEG_SPOP_SBC_1	112:116	PLSTS	SPOP	0.7993	More...
Q86Y82	Syntaxin-12	DEG_SPOP_SBC_1	90:94	PLSTS	SPOP	0.702	More...
Q8IY33	MICAL-like protein 2	DEG_SPOP_SBC_1	519:523	PLSTS	SPOP	0.9828	More...
Q8IY92	Structure-specific endonuclease subunit SLX4	DEG_SPOP_SBC_1	1448:1452	PLSTS	SPOP	0.9903	More...
Q8NEZ4	Histone-lysine N-methyltransferase 2C	DEG_SPOP_SBC_1	2661:2665	PLSTS	SPOP	0.8392	More...
Q8TEQ6	Gem-associated protein 5	DEG_SPOP_SBC_1	850:854	PLSTS	SPOP	0.9922	More...
Q96KQ4	Apoptosis-stimulating of p53 protein 1	DEG_SPOP_SBC_1	336:340	PLSTS	SPOP	0.9301	More...
Q96Q89	Kinesin-like protein KIF20B	DEG_SPOP_SBC_1	1584:1588	PLSTS	SPOP	0.9863	More...
Q99490	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2	DEG_SPOP_SBC_1	1046:1050	PLSTS	SPOP	0.6945	More...
Q99570	Phosphoinositide 3-kinase regulatory subunit 4	DEG_SPOP_SBC_1	901:905	PLSTS	SPOP	0.9634	More...
Q9H2E6	Semaphorin-6A	DEG_SPOP_SBC_1	1018:1022	PLSTS	SPOP	0.9889	More...
Q9H706	GRB2-associated and regulator of MAPK protein 1	DEG_SPOP_SBC_1	542:546	PLSTS	SPOP	0.9196	More...
Q9HBL0	Tensin-1	DEG_SPOP_SBC_1	1075:1079	PLSTS	SPOP	0.9851	More...
Q9UBP5	Hairy/enhancer-of-split related with YRPW motif protein 2	DEG_SPOP_SBC_1	252:256	PLSTS	SPOP	0.7183	More...
Q6ZUB1	Spermatogenesis-associated protein 31E1	DEG_SPOP_SBC_1	1149:1153	PLSTS	SPOP	0.9944	More...
Q96HE9	Proline-rich protein 11	DEG_SPOP_SBC_1	350:354	PLSTS	SPOP	0.9951	More...
Q6ZU67	BEN domain-containing protein 4	DEG_SPOP_SBC_1	281:285	PLSTS	SPOP	0.8233	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	1617:1621	PLSTS	SPOP	0.5245	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PLSTS

Degron related mutations and impact score

Drug responses associated with MICALL2 mutations

All proteins holding degron of PLSTS