DegronMD - Q6UXF1(TMEM108)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P340T	TCGA-28-5211	GBM	TCGA	LTVTPGTS	DEG_SCF_FBW7_1	336:343	Mutation altering degron motif	0.7031
p.P340T	DO11016	GBM	ICGC	LTVTPGTS	DEG_SCF_FBW7_1	336:343	Mutation altering degron motif	0.7031
p.G44C	TCGA-2Y-A9H9	LIHC	TCGA	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation altering degron motif	0.6489
p.G44C	DO219537	LIHC	ICGC	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation altering degron motif	0.6489
p.T269S	TCGA-43-2581	LUSC	TCGA	APTTT	DEG_SPOP_SBC_1	265:269	Mutation altering degron motif	0.6005
p.T269S	DO26602	LUSC	ICGC	APTTT	DEG_SPOP_SBC_1	265:269	Mutation altering degron motif	0.6005
p.G135R	TCGA-43-5668	LUSC	TCGA	ATTSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.1111
p.G135R	DO233624	GACA	ICGC	ATTSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.1111
p.G135R	DO26608	LUSC	ICGC	ATTSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.1111
p.E89Q	TCGA-46-3769	LUSC	TCGA	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation altering degron motif	0.6744
p.E89Q	DO26590	LUSC	ICGC	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation altering degron motif	0.6744
p.P345H	TCGA-55-7994	LUAD	TCGA	PLSTS	DEG_SPOP_SBC_1	345:349	Mutation altering degron motif	0.7694
p.P345H	DO45311	LUAD	ICGC	PLSTS	DEG_SPOP_SBC_1	345:349	Mutation altering degron motif	0.7694
p.T83A	TCGA-60-2723	LUSC	TCGA	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation rewiring degron network	0.3056
p.T83A	DO27152	LUSC	ICGC	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation rewiring degron network	0.3056
p.P46S	TCGA-90-A4ED	LUSC	TCGA	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation altering degron motif	0.6752
p.P46S	TCGA-D3-A3MU	SKCM	TCGA	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation altering degron motif	0.6752
p.P46S	DO45482	LUSC	ICGC	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation altering degron motif	0.6752
p.P46S	DO220884	MELA	ICGC	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation altering degron motif	0.6752
p.P46S	DO47337	SKCM	ICGC	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation altering degron motif	0.6752
p.G48E	TCGA-A2-A0EO	BRCA	TCGA	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation altering degron motif	0.6087
p.G48E	DO3816	BRCA	ICGC	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation altering degron motif	0.6087
p.G427S	TCGA-A6-2686	COAD	TCGA	TMTDRVPSP	DEG_COP1_1	409:417	Mutation rewiring degron network	0.0556
p.G427S	DO7828	COAD	ICGC	TMTDRVPSP	DEG_COP1_1	409:417	Mutation rewiring degron network	0.0556
p.E130Q	TCGA-A8-A0A7	BRCA	TCGA	ATTSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.25
p.E130Q	DO5936	BRCA	ICGC	ATTSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.25
p.R159H	TCGA-AA-3685	COAD	TCGA	PRTTT	DEG_SPOP_SBC_1	158:162	Mutation altering degron motif	0.7133
p.R159H	DO8047	COAD	ICGC	PRTTT	DEG_SPOP_SBC_1	158:162	Mutation altering degron motif	0.7133
p.R159H	DO224596	PACA	ICGC	PRTTT	DEG_SPOP_SBC_1	158:162	Mutation altering degron motif	0.7133
p.A53T	TCGA-AJ-A3EK	UCEC	TCGA	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation rewiring degron network	0.2222
p.A53T	TCGA-AJ-A3EK	UCEC	TCGA	PHSST	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.3056
p.A53T	DO41584	UCEC	ICGC	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation rewiring degron network	0.2222
p.A53T	DO41584	UCEC	ICGC	PHSST	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.3056
p.P168S	TCGA-AP-A059	UCEC	TCGA	PRTTT	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.1667
p.P168S	DO41361	UCEC	ICGC	PRTTT	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.1667
p.P74S	TCGA-AX-A1CE	UCEC	TCGA	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation rewiring degron network	0.0556
p.P74S	DO42280	UCEC	ICGC	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation rewiring degron network	0.0556
p.A149G	TCGA-B5-A11H	UCEC	TCGA	PRTTT	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.0833
p.A149G	DO42825	UCEC	ICGC	PRTTT	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.0833
p.T404I	TCGA-B5-A3FA	UCEC	TCGA	TMTDRVPSP	DEG_COP1_1	409:417	Mutation rewiring degron network	0.1944
p.T404I	DO52402	UCEC	ICGC	TMTDRVPSP	DEG_COP1_1	409:417	Mutation rewiring degron network	0.1944
p.S62Y	TCGA-BK-A6W3	UCEC	TCGA	PHSST	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.2222
p.S62Y	DO50076	UCEC	ICGC	PHSST	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.2222
p.Q326H	TCGA-D1-A2G5	UCEC	TCGA	LTVTPGTS	DEG_SCF_FBW7_1	336:343	Mutation rewiring degron network	0.0556
p.Q326H	DO40918	UCEC	ICGC	LTVTPGTS	DEG_SCF_FBW7_1	336:343	Mutation rewiring degron network	0.0556
p.H55Y	TCGA-E5-A4U1	BLCA	TCGA	PHSST	DEG_SPOP_SBC_1	54:58	Mutation altering degron motif	0.6118
p.H55Y	DO44061	BLCA	ICGC	PHSST	DEG_SPOP_SBC_1	54:58	Mutation altering degron motif	0.6118
p.P80L	TCGA-EB-A5UN	SKCM	TCGA	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation rewiring degron network	0.2222
p.P80L	DO47267	SKCM	ICGC	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation rewiring degron network	0.2222
p.G148R	TCGA-EE-A2GU	SKCM	TCGA	PRTTT	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.0556
p.G148R	DO37639	SKCM	ICGC	PRTTT	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.0556
p.L418F	TCGA-EE-A2M5	SKCM	TCGA	TMTDRVPSP	DEG_COP1_1	409:417	Mutation rewiring degron network	0.3056
p.L418F	DO222423	MELA	ICGC	TMTDRVPSP	DEG_COP1_1	409:417	Mutation rewiring degron network	0.3056
p.L418F	DO37425	SKCM	ICGC	TMTDRVPSP	DEG_COP1_1	409:417	Mutation rewiring degron network	0.3056
p.S126F	TCGA-EE-A2MJ	SKCM	TCGA	ATTSS	DEG_SPOP_SBC_1	123:127	Mutation altering degron motif	0.7982
p.S126F	DO38099	SKCM	ICGC	ATTSS	DEG_SPOP_SBC_1	123:127	Mutation altering degron motif	0.7982
p.G399E	TCGA-EK-A2RJ	CESC	TCGA	TMTDRVPSP	DEG_COP1_1	409:417	Mutation rewiring degron network	0.0556
p.G399E	DO49950	CESC	ICGC	TMTDRVPSP	DEG_COP1_1	409:417	Mutation rewiring degron network	0.0556
p.S43L	TCGA-EO-A22U	UCEC	TCGA	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation altering degron motif	0.6556
p.S43L	DO43755	UCEC	ICGC	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation altering degron motif	0.6556
p.P34S	TCGA-ER-A1A1	SKCM	TCGA	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation rewiring degron network	0.1111
p.P34S	DO37413	SKCM	ICGC	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation rewiring degron network	0.1111
p.S75L	TCGA-ER-A2NE	SKCM	TCGA	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation rewiring degron network	0.0833
p.S75L	DO48663	SKCM	ICGC	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation rewiring degron network	0.0833
p.E89K	TCGA-FR-A728	SKCM	TCGA	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation altering degron motif	0.7022
p.E89K	DO48550	SKCM	ICGC	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation altering degron motif	0.7022
p.M81I	TCGA-G4-6586	COAD	TCGA	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation rewiring degron network	0.25
p.M81I	DO9698	COAD	ICGC	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation rewiring degron network	0.25
p.M81I	SIDM01146	Gastric Carcinoma	GDSC	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation rewiring degron network	0.25
p.M81I	ACH-000932	Gastric Cancer	CCLE	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation rewiring degron network	0.25
p.M81I	NCI-SNU-1	stomach	COSMIC	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation rewiring degron network	0.25
p.R413Q	TCGA-IB-7654	PAAD	TCGA	TMTDRVPSP	DEG_COP1_1	409:417	Mutation altering degron motif	0.6218
p.R413Q	DO51695	PAAD	ICGC	TMTDRVPSP	DEG_COP1_1	409:417	Mutation altering degron motif	0.6218
p.M410I	TCGA-IR-A3LH	CESC	TCGA	TMTDRVPSP	DEG_COP1_1	409:417	Mutation altering degron motif	0.6507
p.M410I	DO44381	CESC	ICGC	TMTDRVPSP	DEG_COP1_1	409:417	Mutation altering degron motif	0.6507
p.E65Q	DO51866	BLCA	ICGC	PHSST	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.1389
p.R163C	DO230335	COCA	ICGC	PRTTT	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.3056
p.R163C	SIDM00238	Ovarian Carcinoma	GDSC	PRTTT	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.3056
p.R163C	ACH-000947	Ovarian Cancer	CCLE	PRTTT	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.3056
p.R163C	OVK-18	ovary	COSMIC	PRTTT	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.3056
p.A118T	DO230333	COCA	ICGC	ATTSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.1944
p.R35G	DO234459	ESAD	ICGC	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation rewiring degron network	0.1389
p.D412Y	DO233246	GACA	ICGC	TMTDRVPSP	DEG_COP1_1	409:417	Mutation altering degron motif	0.6214
p.G116W	DO233259	GACA	ICGC	ATTSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.1389
p.A156V	DO233270	GACA	ICGC	PRTTT	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.2778
p.E65K	DO14566	HNSC	ICGC	PHSST	DEG_SPOP_SBC_1	54:58	Mutation rewiring degron network	0.1389
p.V97L	DO228974	LICA	ICGC	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation rewiring degron network	0.1111
p.V97L	DO26490	LUSC	ICGC	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation rewiring degron network	0.1111
p.R49S	DO229027	LICA	ICGC	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation altering degron motif	0.7427
p.W335C	DO229051	LICA	ICGC	LTVTPGTS	DEG_SCF_FBW7_1	336:343	Mutation rewiring degron network	0.3056
p.W335C	DO229051	LICA	ICGC	PLSTS	DEG_SPOP_SBC_1	345:349	Mutation rewiring degron network	0.0556
p.P93L	DO50970	LICA	ICGC	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation rewiring degron network	0.2222
p.P54H	DO50966	LICA	ICGC	PHSST	DEG_SPOP_SBC_1	54:58	Mutation altering degron motif	0.7694
p.G170V	DO23262	LINC	ICGC	PRTTT	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.1111
p.R87C	DO23146	LINC	ICGC	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation altering degron motif	0.719
p.R87C	DO45071	LINC	ICGC	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation altering degron motif	0.719
p.T94M	DO45299	LIRI	ICGC	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation rewiring degron network	0.1944
p.S126T	DO224605	LUSC	ICGC	ATTSS	DEG_SPOP_SBC_1	123:127	Mutation altering degron motif	0.6005
p.P46F	DO220884	MELA	ICGC	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation altering degron motif	0.7897
p.P46L	DO220884	MELA	ICGC	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation altering degron motif	0.7582
p.P46L	DO222908	MELA	ICGC	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation altering degron motif	0.7582
p.P46L	HCC-56	large intestine	COSMIC	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation altering degron motif	0.7582
p.R134Q	DO220902	MELA	ICGC	ATTSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.1389
p.K275N	DO222749	MELA	ICGC	APTTT	DEG_SPOP_SBC_1	265:269	Mutation substituting flanking lysine	0.2778
p.D276G	DO232761	PBCA	ICGC	APTTT	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.1389
p.S36N	DO220047	SARC	ICGC	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation rewiring degron network	0.1667
p.M84V	DO41919	UCEC	ICGC	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation altering degron motif	0.7208
p.A255V	SIDM02055	Colorectal Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.0556
p.P157H	SIDM00086	Kidney Carcinoma	GDSC	PRTTT	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.3056
p.P157H	SIDM00176	Chondrosarcoma	GDSC	PRTTT	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.3056
p.P157H	CHSA8926	bone	COSMIC	PRTTT	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.3056
p.P157H	RXF393	kidney	COSMIC	PRTTT	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.3056
p.T115I	SIDM00525	Osteosarcoma	GDSC	ATTSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.1111
p.T115I	ACH-000359	Bone Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.1111
p.T115I	MG-63	bone	COSMIC	ATTSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.1111
p.E36Q	SIDM01005	Acute Myeloid Leukemia	GDSC	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation rewiring degron network	0.1667
p.E36Q	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation rewiring degron network	0.1667
p.E36Q	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation rewiring degron network	0.1667
p.E36Q	SIDM00360	Other Solid Cancers	GDSC	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation rewiring degron network	0.1667
p.E36Q	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation rewiring degron network	0.1667
p.E36Q	SIDM00271	Gastric Carcinoma	GDSC	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation rewiring degron network	0.1667
p.E36Q	SIDM01449	Pancreatic Carcinoma	GDSC	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation rewiring degron network	0.1667
p.E36Q	SIDM01335	Kidney Carcinoma	GDSC	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation rewiring degron network	0.1667
p.E36Q	SIDM00008	Ovarian Carcinoma	GDSC	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation rewiring degron network	0.1667
p.E36Q	SIDM01435	Hepatocellular Carcinoma	GDSC	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation rewiring degron network	0.1667
p.E36Q	SIDM01442	Glioma	GDSC	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation rewiring degron network	0.1667
p.E36Q	SIDM01343	Gastric Carcinoma	GDSC	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation rewiring degron network	0.1667
p.E36Q	SIDM00159	Biliary Tract Carcinoma	GDSC	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation rewiring degron network	0.1667
p.A123E	SIDM00590	Oral Cavity Carcinoma	GDSC	ATTSS	DEG_SPOP_SBC_1	123:127	Mutation altering degron motif	0.7701
p.A123E	ACH-000472	Head and Neck Cancer	CCLE	ATTSS	DEG_SPOP_SBC_1	123:127	Mutation altering degron motif	0.7701
p.A123E	HSC-2	upper aerodigestive tract	COSMIC	ATTSS	DEG_SPOP_SBC_1	123:127	Mutation altering degron motif	0.7701
p.P86T	SIDM00155	Head and Neck Carcinoma	GDSC	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation altering degron motif	0.7031
p.P86T	ACH-002296	Head and Neck Cancer	CCLE	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation altering degron motif	0.7031
p.P86T	PCI-38	upper aerodigestive tract	COSMIC	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation altering degron motif	0.7031
p.P47R	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation altering degron motif	0.6401
p.D276N	SIDM01079	Melanoma	GDSC	APTTT	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.1389
p.D276N	ACH-000441	Skin Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.1389
p.D276N	SH-4	skin	COSMIC	APTTT	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.1389
p.S343N	SIDM01113	Other Sarcomas	GDSC	LTVTPGTS	DEG_SCF_FBW7_1	336:343	Mutation altering degron motif	0.7069
p.S343N	ACH-000939	Sarcoma	CCLE	LTVTPGTS	DEG_SCF_FBW7_1	336:343	Mutation altering degron motif	0.7069
p.S343N	SK-UT-1	soft tissue	COSMIC	LTVTPGTS	DEG_SCF_FBW7_1	336:343	Mutation altering degron motif	0.7069
p.P84S	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation altering degron motif	0.6752
p.P84S	ACH-001642	Lymphoma	CCLE	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation altering degron motif	0.6752
p.P84S	SCC-3	haematopoietic and lymphoid tissue	COSMIC	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation altering degron motif	0.6752
p.S334F	SIDM00217	Colorectal Carcinoma	GDSC	LTVTPGTS	DEG_SCF_FBW7_1	336:343	Mutation rewiring degron network	0.2778
p.S334F	ACH-000999	Colon/Colorectal Cancer	CCLE	LTVTPGTS	DEG_SCF_FBW7_1	336:343	Mutation rewiring degron network	0.2778
p.S334F	SNU-1040	large intestine	COSMIC	LTVTPGTS	DEG_SCF_FBW7_1	336:343	Mutation rewiring degron network	0.2778
p.S114C	SIDM00153	T-Lymphoblastic Leukemia	GDSC	ATTSS	DEG_SPOP_SBC_1	123:127	Mutation rewiring degron network	0.0833
p.T404A	SIDM00228	Thyroid Gland Carcinoma	GDSC	TMTDRVPSP	DEG_COP1_1	409:417	Mutation rewiring degron network	0.1944
p.T404A	ACH-000897	Thyroid Cancer	CCLE	TMTDRVPSP	DEG_COP1_1	409:417	Mutation rewiring degron network	0.1944
p.R163H	SIDM01752	Pancreatic Carcinoma	GDSC	PRTTT	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.3056
p.E89D	SIDM01729	Endometrial Carcinoma	GDSC	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation altering degron motif	0.6758
p.E89D	ACH-000909	Endometrial/Uterine Cancer	CCLE	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation altering degron motif	0.6758
p.P158S	ACH-000799	Skin Cancer	CCLE	PRTTT	DEG_SPOP_SBC_1	158:162	Mutation altering degron motif	0.6752
p.T411A	ACH-001610	Brain Cancer	CCLE	TMTDRVPSP	DEG_COP1_1	409:417	Mutation altering degron motif	0.7139
p.T262I	ACH-001956	Bone Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.25
p.T269P	ACH-002297	Head and Neck Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	265:269	Mutation altering degron motif	0.7031
p.T155P	ACH-002659	Colon/Colorectal Cancer	CCLE	PRTTT	DEG_SPOP_SBC_1	158:162	Mutation rewiring degron network	0.25
p.D81E	KMH-2	thyroid	COSMIC	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation rewiring degron network	0.25
p.A75V	CW-2	large intestine	COSMIC	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation rewiring degron network	0.0833
p.G98E	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PTPRAE	DEG_SCF_FBW7_2	84:89	Mutation rewiring degron network	0.0833
p.E32D	SNU-81	large intestine	COSMIC	PSGTPPGT	DEG_SCF_FBW7_1	42:49	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMEM108

UniProt ID: Q6UXF1

Entrez ID: 66000

Protein name: Transmembrane protein 108 (Retrolinkin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMEM108 in