DegronMD

Uniprot ID: Q6UXF1

Source protein: Transmembrane protein 108

Source gene: TMEM108

Class: DEG_SCF_FBW7_1

Location: 42:49

E3 ligase: FBXW7

DEGRON score: 0.9899

ASA_SCORE: 80.65

COIL: 0.9631

CONS_SCORE: 0.4074

DSS_SCORE: 0.5996

HELIX: 0.013

FCONS_SCORE: 0.9803

RIG_SCORE: 0.5661

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G44C	TCGA-2Y-A9H9	LIHC	TCGA	PSGTPPGT	DEG_SCF_FBW7_1	0.6489
p.G44C	DO219537	LIHC	ICGC	PSGTPPGT	DEG_SCF_FBW7_1	0.6489
p.P46S	TCGA-90-A4ED	LUSC	TCGA	PSGTPPGT	DEG_SCF_FBW7_1	0.6752
p.P46S	TCGA-D3-A3MU	SKCM	TCGA	PSGTPPGT	DEG_SCF_FBW7_1	0.6752
p.P46S	DO45482	LUSC	ICGC	PSGTPPGT	DEG_SCF_FBW7_1	0.6752
p.P46S	DO220884	MELA	ICGC	PSGTPPGT	DEG_SCF_FBW7_1	0.6752
p.P46S	DO47337	SKCM	ICGC	PSGTPPGT	DEG_SCF_FBW7_1	0.6752
p.G48E	TCGA-A2-A0EO	BRCA	TCGA	PSGTPPGT	DEG_SCF_FBW7_1	0.6087
p.G48E	DO3816	BRCA	ICGC	PSGTPPGT	DEG_SCF_FBW7_1	0.6087
p.A53T	TCGA-AJ-A3EK	UCEC	TCGA	PSGTPPGT	DEG_SCF_FBW7_1	0.2222
p.A53T	DO41584	UCEC	ICGC	PSGTPPGT	DEG_SCF_FBW7_1	0.2222
p.S43L	TCGA-EO-A22U	UCEC	TCGA	PSGTPPGT	DEG_SCF_FBW7_1	0.6556
p.S43L	DO43755	UCEC	ICGC	PSGTPPGT	DEG_SCF_FBW7_1	0.6556
p.P34S	TCGA-ER-A1A1	SKCM	TCGA	PSGTPPGT	DEG_SCF_FBW7_1	0.1111
p.P34S	DO37413	SKCM	ICGC	PSGTPPGT	DEG_SCF_FBW7_1	0.1111
p.R35G	DO234459	ESAD	ICGC	PSGTPPGT	DEG_SCF_FBW7_1	0.1389
p.R49S	DO229027	LICA	ICGC	PSGTPPGT	DEG_SCF_FBW7_1	0.7427
p.P46F	DO220884	MELA	ICGC	PSGTPPGT	DEG_SCF_FBW7_1	0.7897
p.P46L	DO220884	MELA	ICGC	PSGTPPGT	DEG_SCF_FBW7_1	0.7582
p.P46L	DO222908	MELA	ICGC	PSGTPPGT	DEG_SCF_FBW7_1	0.7582
p.P46L	HCC-56	large_intestine	COSMIC	PSGTPPGT	DEG_SCF_FBW7_1	0.7582
p.S36N	DO220047	SARC	ICGC	PSGTPPGT	DEG_SCF_FBW7_1	0.1667
p.E36Q	SIDM01005	Acute Myeloid Leukemia	GDSC	PSGTPPGT	DEG_SCF_FBW7_1	0.1667
p.E36Q	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	PSGTPPGT	DEG_SCF_FBW7_1	0.1667
p.E36Q	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	PSGTPPGT	DEG_SCF_FBW7_1	0.1667
p.E36Q	SIDM00360	Other Solid Cancers	GDSC	PSGTPPGT	DEG_SCF_FBW7_1	0.1667
p.E36Q	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	PSGTPPGT	DEG_SCF_FBW7_1	0.1667
p.E36Q	SIDM00271	Gastric Carcinoma	GDSC	PSGTPPGT	DEG_SCF_FBW7_1	0.1667
p.E36Q	SIDM01449	Pancreatic Carcinoma	GDSC	PSGTPPGT	DEG_SCF_FBW7_1	0.1667
p.E36Q	SIDM01335	Kidney Carcinoma	GDSC	PSGTPPGT	DEG_SCF_FBW7_1	0.1667
p.E36Q	SIDM00008	Ovarian Carcinoma	GDSC	PSGTPPGT	DEG_SCF_FBW7_1	0.1667
p.E36Q	SIDM01435	Hepatocellular Carcinoma	GDSC	PSGTPPGT	DEG_SCF_FBW7_1	0.1667
p.E36Q	SIDM01442	Glioma	GDSC	PSGTPPGT	DEG_SCF_FBW7_1	0.1667
p.E36Q	SIDM01343	Gastric Carcinoma	GDSC	PSGTPPGT	DEG_SCF_FBW7_1	0.1667
p.E36Q	SIDM00159	Biliary Tract Carcinoma	GDSC	PSGTPPGT	DEG_SCF_FBW7_1	0.1667
p.P47R	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PSGTPPGT	DEG_SCF_FBW7_1	0.6401
p.E32D	SNU-81	large_intestine	COSMIC	PSGTPPGT	DEG_SCF_FBW7_1	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSGTPPGT

Degron related mutations and impact score

Drug responses associated with TMEM108 mutations

All proteins holding degron of PSGTPPGT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UXF1	Transmembrane protein 108	DEG_SCF_FBW7_1	42:49	PSGTPPGT	FBXW7	0.9899	More...