DegronMD

Uniprot ID: Q6UXF1

Source protein: Transmembrane protein 108

Source gene: TMEM108

Class: DEG_COP1_1

Location: 409:417

E3 ligase: COP1

DEGRON score: 0.9945

ASA_SCORE: 99.2889

COIL: 0.9376

CONS_SCORE: 0.3906

DSS_SCORE: 0.4622

HELIX: 0.0391

FCONS_SCORE: 0.7876

RIG_SCORE: 0.7749

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T411A	ACH-001610	Brain Cancer	CCLE	TMTDRVPSP	DEG_COP1_1	0.7139
p.M410I	TCGA-IR-A3LH	CESC	TCGA	TMTDRVPSP	DEG_COP1_1	0.6507
p.M410I	DO44381	CESC	ICGC	TMTDRVPSP	DEG_COP1_1	0.6507
p.R413Q	TCGA-IB-7654	PAAD	TCGA	TMTDRVPSP	DEG_COP1_1	0.6218
p.R413Q	DO51695	PAAD	ICGC	TMTDRVPSP	DEG_COP1_1	0.6218
p.D412Y	DO233246	GACA	ICGC	TMTDRVPSP	DEG_COP1_1	0.6214
p.L418F	TCGA-EE-A2M5	SKCM	TCGA	TMTDRVPSP	DEG_COP1_1	0.3056
p.L418F	DO222423	MELA	ICGC	TMTDRVPSP	DEG_COP1_1	0.3056
p.L418F	DO37425	SKCM	ICGC	TMTDRVPSP	DEG_COP1_1	0.3056
p.T404I	TCGA-B5-A3FA	UCEC	TCGA	TMTDRVPSP	DEG_COP1_1	0.1944
p.T404I	DO52402	UCEC	ICGC	TMTDRVPSP	DEG_COP1_1	0.1944
p.T404A	SIDM00228	Thyroid Gland Carcinoma	GDSC	TMTDRVPSP	DEG_COP1_1	0.1944
p.T404A	ACH-000897	Thyroid Cancer	CCLE	TMTDRVPSP	DEG_COP1_1	0.1944
p.G427S	TCGA-A6-2686	COAD	TCGA	TMTDRVPSP	DEG_COP1_1	0.0556
p.G427S	DO7828	COAD	ICGC	TMTDRVPSP	DEG_COP1_1	0.0556
p.G399E	TCGA-EK-A2RJ	CESC	TCGA	TMTDRVPSP	DEG_COP1_1	0.0556
p.G399E	DO49950	CESC	ICGC	TMTDRVPSP	DEG_COP1_1	0.0556

Showing 1 to 17 of 17 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UXF1	Transmembrane protein 108	DEG_COP1_1	409:417	TMTDRVPSP	COP1	0.9945	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons