DegronMD

Uniprot ID: Q6UXF1

Source protein: Transmembrane protein 108

Source gene: TMEM108

Class: DEG_SCF_FBW7_1

Location: 336:343

E3 ligase: FBXW7

DEGRON score: 0.9984

ASA_SCORE: 74.8875

COIL: 0.9266

CONS_SCORE: 0.5472

DSS_SCORE: 0.6296

HELIX: 0.0251

FCONS_SCORE: 1.1023

RIG_SCORE: 0.6604

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P340T	TCGA-28-5211	GBM	TCGA	LTVTPGTS	DEG_SCF_FBW7_1	0.7031
p.P340T	DO11016	GBM	ICGC	LTVTPGTS	DEG_SCF_FBW7_1	0.7031
p.Q326H	TCGA-D1-A2G5	UCEC	TCGA	LTVTPGTS	DEG_SCF_FBW7_1	0.0556
p.Q326H	DO40918	UCEC	ICGC	LTVTPGTS	DEG_SCF_FBW7_1	0.0556
p.W335C	DO229051	LICA	ICGC	LTVTPGTS	DEG_SCF_FBW7_1	0.3056
p.S343N	SIDM01113	Other Sarcomas	GDSC	LTVTPGTS	DEG_SCF_FBW7_1	0.7069
p.S343N	ACH-000939	Sarcoma	CCLE	LTVTPGTS	DEG_SCF_FBW7_1	0.7069
p.S343N	SK-UT-1	soft_tissue	COSMIC	LTVTPGTS	DEG_SCF_FBW7_1	0.7069
p.S334F	SIDM00217	Colorectal Carcinoma	GDSC	LTVTPGTS	DEG_SCF_FBW7_1	0.2778
p.S334F	ACH-000999	Colon/Colorectal Cancer	CCLE	LTVTPGTS	DEG_SCF_FBW7_1	0.2778
p.S334F	SNU-1040	large_intestine	COSMIC	LTVTPGTS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UXF1	Transmembrane protein 108	DEG_SCF_FBW7_1	336:343	LTVTPGTS	FBXW7	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons