DegronMD

Uniprot ID: Q6UXF1

Source protein: Transmembrane protein 108

Source gene: TMEM108

Class: DEG_SPOP_SBC_1

Location: 265:269

E3 ligase: SPOP

DEGRON score: 0.9989

ASA_SCORE: 78.1

COIL: 0.934

CONS_SCORE: 0.5613

DSS_SCORE: 0.6394

HELIX: 0.0198

FCONS_SCORE: 1.1214

RIG_SCORE: 0.7249

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T269S	TCGA-43-2581	LUSC	TCGA	APTTT	DEG_SPOP_SBC_1	0.6005
p.T269S	DO26602	LUSC	ICGC	APTTT	DEG_SPOP_SBC_1	0.6005
p.K275N	DO222749	MELA	ICGC	APTTT	DEG_SPOP_SBC_1	0.2778
p.D276G	DO232761	PBCA	ICGC	APTTT	DEG_SPOP_SBC_1	0.1389
p.A255V	SIDM02055	Colorectal Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	0.0556
p.D276N	SIDM01079	Melanoma	GDSC	APTTT	DEG_SPOP_SBC_1	0.1389
p.D276N	ACH-000441	Skin Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	0.1389
p.D276N	SH-4	skin	COSMIC	APTTT	DEG_SPOP_SBC_1	0.1389
p.T262I	ACH-001956	Bone Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	0.25
p.T269P	ACH-002297	Head and Neck Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	DEG_SPOP_SBC_1	1556:1560	APTTT	SPOP	0.999	More...
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	777:781	APTTT	SPOP	0.9974	More...
O00257	E3 SUMO-protein ligase CBX4	DEG_SPOP_SBC_1	510:514	APTTT	SPOP	0.9085	More...
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	741:745	APTTT	SPOP	0.9972	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1822:1826	APTTT	SPOP	0.9757	More...
O96005	Cleft lip and palate transmembrane protein 1	DEG_SPOP_SBC_1	626:630	APTTT	SPOP	0.9015	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1323:1327	APTTT	SPOP	0.628	More...
Q5T4S7	E3 ubiquitin-protein ligase UBR4	DEG_SPOP_SBC_1	2466:2470	APTTT	SPOP	0.88	More...
Q6SA08	Testis-specific serine/threonine-protein kinase 4	DEG_SPOP_SBC_1	10:14	APTTT	SPOP	0.7213	More...
Q6UXF1	Transmembrane protein 108	DEG_SPOP_SBC_1	265:269	APTTT	SPOP	0.9989	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	382:386	APTTT	SPOP	0.9417	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	397:401	APTTT	SPOP	0.7673	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	413:417	APTTT	SPOP	0.8995	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	421:425	APTTT	SPOP	0.9979	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	507:511	APTTT	SPOP	0.9358	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	523:527	APTTT	SPOP	0.9092	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	530:534	APTTT	SPOP	0.9944	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	538:542	APTTT	SPOP	0.9813	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	593:597	APTTT	SPOP	0.9962	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	734:738	APTTT	SPOP	0.6542	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	803:807	APTTT	SPOP	0.9052	More...
Q96AE4	Far upstream element-binding protein 1	DEG_SPOP_SBC_1	559:563	APTTT	SPOP	0.9606	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	800:804	APTTT	SPOP	0.9952	More...
Q9Y5Y7	Lymphatic vessel endothelial hyaluronic acid receptor 1	DEG_SPOP_SBC_1	180:184	APTTT	SPOP	0.926	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	384:388	APTTT	SPOP	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APTTT

Degron related mutations and impact score

Drug responses associated with TMEM108 mutations

All proteins holding degron of APTTT