DegronMD

Uniprot ID: Q92954

Source protein: Proteoglycan 4

Source gene: PRG4

Class: DEG_SPOP_SBC_1

Location: 538:542

E3 ligase: SPOP

DEGRON score: 0.9813

ASA_SCORE: 98.46

COIL: 0.9678

CONS_SCORE: 0.205

DSS_SCORE: 0.7756

HELIX: 0.0124

FCONS_SCORE: 0.5487

RIG_SCORE: 0.5831

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S544P	ACH-000693	Esophageal Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	0.7222
p.S544P	KYSE-180	oesophagus	COSMIC	APTTT	DEG_SPOP_SBC_1	0.7222
p.A540T	SK-GT-2	stomach	COSMIC	APTTT	DEG_SPOP_SBC_1	0.7139
p.A540T	NCI-N87	stomach	COSMIC	APTTT	DEG_SPOP_SBC_1	0.7139
p.T542P	ACH-000411	Kidney Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	0.7031
p.T542P	ACH-001347	Head and Neck Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	0.7031
p.T542P	ACH-001430	Bone Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	0.7031
p.K538E	SK-GT-2	stomach	COSMIC	APTTT	DEG_SPOP_SBC_1	0.7022
p.T535P	CW-2	large_intestine	COSMIC	APTTT	DEG_SPOP_SBC_1	0.3611
p.P537S	SIDM01304	Colorectal Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	0.3056
p.P537S	SIDM00803	Kidney Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	0.3056
p.E537Q	QIMR-WIL	haematopoietic_and_lymphoid_tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	0.3056
p.E536K	DO229250	THCA	ICGC	APTTT	DEG_SPOP_SBC_1	0.2778
p.P546S	TCGA-HT-8109	LGG	TCGA	APTTT	DEG_SPOP_SBC_1	0.2222
p.P546S	DO22183	LGG	ICGC	APTTT	DEG_SPOP_SBC_1	0.2222
p.P547L	SU-DHL-8	NS	COSMIC	APTTT	DEG_SPOP_SBC_1	0.1944
p.A548T	NCI-H1693	lung	COSMIC	APTTT	DEG_SPOP_SBC_1	0.1667
p.T551N	D-566MG	central_nervous_system	COSMIC	APTTT	DEG_SPOP_SBC_1	0.0833

Showing 1 to 18 of 18 entries

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Drug responses associated with PRG4 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of APTTT

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1822:1826	APTTT	SPOP	0.9757	More...
O96005	Cleft lip and palate transmembrane protein 1	DEG_SPOP_SBC_1	626:630	APTTT	SPOP	0.9015	More...
O00257	E3 SUMO-protein ligase CBX4	DEG_SPOP_SBC_1	510:514	APTTT	SPOP	0.9085	More...
Q5T4S7	E3 ubiquitin-protein ligase UBR4	DEG_SPOP_SBC_1	2466:2470	APTTT	SPOP	0.88	More...
Q96AE4	Far upstream element-binding protein 1	DEG_SPOP_SBC_1	559:563	APTTT	SPOP	0.9606	More...
Q9Y5Y7	Lymphatic vessel endothelial hyaluronic acid receptor 1	DEG_SPOP_SBC_1	180:184	APTTT	SPOP	0.926	More...
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	741:745	APTTT	SPOP	0.9972	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1323:1327	APTTT	SPOP	0.628	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	800:804	APTTT	SPOP	0.9952	More...
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	777:781	APTTT	SPOP	0.9974	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	382:386	APTTT	SPOP	0.9417	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	397:401	APTTT	SPOP	0.7673	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	413:417	APTTT	SPOP	0.8995	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	421:425	APTTT	SPOP	0.9979	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	507:511	APTTT	SPOP	0.9358	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	523:527	APTTT	SPOP	0.9092	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	530:534	APTTT	SPOP	0.9944	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	538:542	APTTT	SPOP	0.9813	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	593:597	APTTT	SPOP	0.9962	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	734:738	APTTT	SPOP	0.6542	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	803:807	APTTT	SPOP	0.9052	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	384:388	APTTT	SPOP	0.9984	More...
A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	DEG_SPOP_SBC_1	1556:1560	APTTT	SPOP	0.999	More...
Q6SA08	Testis-specific serine/threonine-protein kinase 4	DEG_SPOP_SBC_1	10:14	APTTT	SPOP	0.7213	More...
Q6UXF1	Transmembrane protein 108	DEG_SPOP_SBC_1	265:269	APTTT	SPOP	0.9989	More...

Showing 1 to 25 of 25 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APTTT

Degron related mutations and impact score

Drug responses associated with PRG4 mutations

All proteins holding degron of APTTT