DegronMD - O96005(CLPTM1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T629M	TCGA-CV-6003	HNSC	TCGA	APTTT	DEG_SPOP_SBC_1	626:630	Mutation altering degron motif	0.7423
p.T616I	TCGA-EC-A1QX	UCEC	TCGA	LTPTPAPT	DEG_SCF_FBW7_1	621:628	Mutation blocking phosphorylation signal	0.6389
p.T616I	TCGA-EC-A1QX	UCEC	TCGA	APTTT	DEG_SPOP_SBC_1	626:630	Mutation blocking phosphorylation signal	0.5
p.T622M	TCGA-FD-A3B5	BLCA	TCGA	LTPTPAPT	DEG_SCF_FBW7_1	621:628	Mutation altering degron motif	0.7423
p.V611M	TCGA-XU-A92Q	THYM	TCGA	LTPTPAPT	DEG_SCF_FBW7_1	621:628	Mutation rewiring degron network	0.0556
p.T625M	DO224944	BRCA	ICGC	LTPTPAPT	DEG_SCF_FBW7_1	621:628	Mutation altering degron motif	0.7423
p.T615M	DO15639	HNSC	ICGC	LTPTPAPT	DEG_SCF_FBW7_1	621:628	Mutation rewiring degron network	0.1667
p.A638T	DO232998	PEME	ICGC	LTPTPAPT	DEG_SCF_FBW7_1	621:628	Mutation rewiring degron network	0.0556
p.A638T	DO232998	PEME	ICGC	APTTT	DEG_SPOP_SBC_1	626:630	Mutation rewiring degron network	0.1111
p.S637F	DO218850	SKCA	ICGC	LTPTPAPT	DEG_SCF_FBW7_1	621:628	Mutation rewiring degron network	0.0833
p.S637F	DO218850	SKCA	ICGC	APTTT	DEG_SPOP_SBC_1	626:630	Mutation rewiring degron network	0.1389
p.E640K	DO50291	SKCM	ICGC	APTTT	DEG_SPOP_SBC_1	626:630	Mutation rewiring degron network	0.0556
p.T622R	SIDM00709	Non-Small Cell Lung Carcinoma	GDSC	LTPTPAPT	DEG_SCF_FBW7_1	621:628	Mutation altering degron motif	0.7876
p.T622R	NCI-H2085	lung	COSMIC	LTPTPAPT	DEG_SCF_FBW7_1	621:628	Mutation altering degron motif	0.7876
p.R620K	ACH-001518	Endometrial/Uterine Cancer	CCLE	LTPTPAPT	DEG_SCF_FBW7_1	621:628	Mutation rewiring degron network	0.3056
p.R620K	ACH-001518	Endometrial/Uterine Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	626:630	Mutation rewiring degron network	0.1667

Kaplan plot for CLPTM1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CLPTM1

UniProt ID: O96005

Entrez ID: 1209

Protein name: Cleft lip and palate transmembrane protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CLPTM1 in