DegronMD

Uniprot ID: O96005

Source protein: Cleft lip and palate transmembrane protein 1

Source gene: CLPTM1

Class: DEG_SCF_FBW7_1

Location: 621:628

E3 ligase: FBXW7

DEGRON score: 0.9586

ASA_SCORE: 93.0125

COIL: 0.951

CONS_SCORE: 0.1574

DSS_SCORE: 0.7154

HELIX: 0.0159

FCONS_SCORE: 0.8561

RIG_SCORE: 0.6497

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T616I	TCGA-EC-A1QX	UCEC	TCGA	LTPTPAPT	DEG_SCF_FBW7_1	0.6389
p.T622M	TCGA-FD-A3B5	BLCA	TCGA	LTPTPAPT	DEG_SCF_FBW7_1	0.7423
p.V611M	TCGA-XU-A92Q	THYM	TCGA	LTPTPAPT	DEG_SCF_FBW7_1	0.0556
p.T625M	DO224944	BRCA	ICGC	LTPTPAPT	DEG_SCF_FBW7_1	0.7423
p.T615M	DO15639	HNSC	ICGC	LTPTPAPT	DEG_SCF_FBW7_1	0.1667
p.A638T	DO232998	PEME	ICGC	LTPTPAPT	DEG_SCF_FBW7_1	0.0556
p.S637F	DO218850	SKCA	ICGC	LTPTPAPT	DEG_SCF_FBW7_1	0.0833
p.T622R	SIDM00709	Non-Small Cell Lung Carcinoma	GDSC	LTPTPAPT	DEG_SCF_FBW7_1	0.7876
p.T622R	NCI-H2085	lung	COSMIC	LTPTPAPT	DEG_SCF_FBW7_1	0.7876
p.R620K	ACH-001518	Endometrial/Uterine Cancer	CCLE	LTPTPAPT	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O96005	Cleft lip and palate transmembrane protein 1	DEG_SCF_FBW7_1	621:628	LTPTPAPT	FBXW7	0.9586	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons