DegronMD - Q9Y5Y7(LYVE1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P185T	TCGA-A6-6653	COAD	TCGA	RRKKLICVT	DEG_APCC_DBOX_1	195:203	Mutation rewiring degron network	0.0556
p.P185T	TCGA-A6-6653	COAD	TCGA	APTTT	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.3056
p.P185T	TCGA-A6-6653	COAD	TCGA	PASTS	DEG_SPOP_SBC_1	188:192	Mutation rewiring degron network	0.25
p.P185T	DO10373	COAD	ICGC	RRKKLICVT	DEG_APCC_DBOX_1	195:203	Mutation rewiring degron network	0.0556
p.P185T	DO10373	COAD	ICGC	APTTT	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.3056
p.P185T	DO10373	COAD	ICGC	PASTS	DEG_SPOP_SBC_1	188:192	Mutation rewiring degron network	0.25
p.F206V	TCGA-E6-A1LX	UCEC	TCGA	RRKKLICVT	DEG_APCC_DBOX_1	195:203	Mutation rewiring degron network	0.25
p.F206V	DO41020	UCEC	ICGC	RRKKLICVT	DEG_APCC_DBOX_1	195:203	Mutation rewiring degron network	0.25
p.S173F	TCGA-EE-A29D	SKCM	TCGA	APTTT	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.1389
p.S173F	DO38123	SKCM	ICGC	APTTT	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.1389
p.K197I	TCGA-EE-A2M5	SKCM	TCGA	RRKKLICVT	DEG_APCC_DBOX_1	195:203	Mutation altering degron motif	0.642
p.K197I	DO222423	MELA	ICGC	RRKKLICVT	DEG_APCC_DBOX_1	195:203	Mutation altering degron motif	0.642
p.K197I	DO37425	SKCM	ICGC	RRKKLICVT	DEG_APCC_DBOX_1	195:203	Mutation altering degron motif	0.642
p.R195Q	TCGA-EO-A3AY	UCEC	TCGA	RRKKLICVT	DEG_APCC_DBOX_1	195:203	Mutation altering degron motif	0.6218
p.R195Q	DO233944	GACA	ICGC	RRKKLICVT	DEG_APCC_DBOX_1	195:203	Mutation altering degron motif	0.6218
p.R195Q	DO43202	UCEC	ICGC	RRKKLICVT	DEG_APCC_DBOX_1	195:203	Mutation altering degron motif	0.6218
p.R195Q	SIDM01175	Other Sarcomas	GDSC	RRKKLICVT	DEG_APCC_DBOX_1	195:203	Mutation altering degron motif	0.6218
p.R195Q	SW684	soft tissue	COSMIC	RRKKLICVT	DEG_APCC_DBOX_1	195:203	Mutation altering degron motif	0.6218
p.P185H	TCGA-EO-A3KX	UCEC	TCGA	RRKKLICVT	DEG_APCC_DBOX_1	195:203	Mutation rewiring degron network	0.0556
p.P185H	TCGA-EO-A3KX	UCEC	TCGA	APTTT	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.3056
p.P185H	TCGA-EO-A3KX	UCEC	TCGA	PASTS	DEG_SPOP_SBC_1	188:192	Mutation rewiring degron network	0.25
p.P185H	DO219774	UCEC	ICGC	RRKKLICVT	DEG_APCC_DBOX_1	195:203	Mutation rewiring degron network	0.0556
p.P185H	DO219774	UCEC	ICGC	APTTT	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.3056
p.P185H	DO219774	UCEC	ICGC	PASTS	DEG_SPOP_SBC_1	188:192	Mutation rewiring degron network	0.25
p.C201R	TCGA-EY-A1GD	UCEC	TCGA	RRKKLICVT	DEG_APCC_DBOX_1	195:203	Mutation altering degron motif	0.719
p.C201R	DO42129	UCEC	ICGC	RRKKLICVT	DEG_APCC_DBOX_1	195:203	Mutation altering degron motif	0.719
p.S192F	TCGA-FR-A7U9	SKCM	TCGA	PASTS	DEG_SPOP_SBC_1	188:192	Mutation altering degron motif	0.7982
p.S192F	DO48546	SKCM	ICGC	PASTS	DEG_SPOP_SBC_1	188:192	Mutation altering degron motif	0.7982
p.T184A	DO229323	BTCA	ICGC	APTTT	DEG_SPOP_SBC_1	180:184	Mutation altering degron motif	0.7139
p.R195W	DO228650	LICA	ICGC	RRKKLICVT	DEG_APCC_DBOX_1	195:203	Mutation altering degron motif	0.7523
p.R195W	DO52365	LUSC	ICGC	RRKKLICVT	DEG_APCC_DBOX_1	195:203	Mutation altering degron motif	0.7523
p.S170L	DO35083	PACA	ICGC	APTTT	DEG_SPOP_SBC_1	180:184	Mutation rewiring degron network	0.0556
p.M212I	DO229213	THCA	ICGC	RRKKLICVT	DEG_APCC_DBOX_1	195:203	Mutation rewiring degron network	0.0833
p.T209A	SIDM02026	Colorectal Carcinoma	GDSC	RRKKLICVT	DEG_APCC_DBOX_1	195:203	Mutation rewiring degron network	0.1667
p.T209S	ACH-000590	Lung Cancer	CCLE	RRKKLICVT	DEG_APCC_DBOX_1	195:203	Mutation rewiring degron network	0.1667
p.T209S	ACH-001137	Lung Cancer	CCLE	RRKKLICVT	DEG_APCC_DBOX_1	195:203	Mutation rewiring degron network	0.1667
p.T209S	NCI-H1993	lung	COSMIC	RRKKLICVT	DEG_APCC_DBOX_1	195:203	Mutation rewiring degron network	0.1667
p.N199K	ACH-000966	Ovarian Cancer	CCLE	RRKKLICVT	DEG_APCC_DBOX_1	195:203	Mutation altering degron motif	0.6918
p.N199K	IGROV-1	ovary	COSMIC	RRKKLICVT	DEG_APCC_DBOX_1	195:203	Mutation altering degron motif	0.6918
p.E202Q	ACH-002218	Leukemia	CCLE	RRKKLICVT	DEG_APCC_DBOX_1	195:203	Mutation altering degron motif	0.6744
p.E202Q	CESS	haematopoietic and lymphoid tissue	COSMIC	RRKKLICVT	DEG_APCC_DBOX_1	195:203	Mutation altering degron motif	0.6744

Kaplan plot for LYVE1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LYVE1

UniProt ID: Q9Y5Y7

Entrez ID: 10894

Protein name: Lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE-1) (Cell surface retention sequence-binding protein 1) (CRSBP-1) (Extracellular link domain-containing protein 1) (Hyaluronic acid receptor)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for LYVE1 in