DegronMD

Uniprot ID: Q9Y5Y7

Source protein: Lymphatic vessel endothelial hyaluronic acid receptor 1

Source gene: LYVE1

Class: DEG_APCC_DBOX_1

Location: 195:203

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9487

ASA_SCORE: 108.2556

COIL: 0.7703

CONS_SCORE: 0.5146

DSS_SCORE: 0.3577

HELIX: 0.0297

FCONS_SCORE: 1.2994

RIG_SCORE: 0.8462

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P185T	TCGA-A6-6653	COAD	TCGA	RRKKLICVT	DEG_APCC_DBOX_1	0.0556
p.P185T	DO10373	COAD	ICGC	RRKKLICVT	DEG_APCC_DBOX_1	0.0556
p.F206V	TCGA-E6-A1LX	UCEC	TCGA	RRKKLICVT	DEG_APCC_DBOX_1	0.25
p.F206V	DO41020	UCEC	ICGC	RRKKLICVT	DEG_APCC_DBOX_1	0.25
p.K197I	TCGA-EE-A2M5	SKCM	TCGA	RRKKLICVT	DEG_APCC_DBOX_1	0.642
p.K197I	DO222423	MELA	ICGC	RRKKLICVT	DEG_APCC_DBOX_1	0.642
p.K197I	DO37425	SKCM	ICGC	RRKKLICVT	DEG_APCC_DBOX_1	0.642
p.R195Q	TCGA-EO-A3AY	UCEC	TCGA	RRKKLICVT	DEG_APCC_DBOX_1	0.6218
p.R195Q	DO233944	GACA	ICGC	RRKKLICVT	DEG_APCC_DBOX_1	0.6218
p.R195Q	DO43202	UCEC	ICGC	RRKKLICVT	DEG_APCC_DBOX_1	0.6218
p.R195Q	SIDM01175	Other Sarcomas	GDSC	RRKKLICVT	DEG_APCC_DBOX_1	0.6218
p.R195Q	SW684	soft_tissue	COSMIC	RRKKLICVT	DEG_APCC_DBOX_1	0.6218
p.P185H	TCGA-EO-A3KX	UCEC	TCGA	RRKKLICVT	DEG_APCC_DBOX_1	0.0556
p.P185H	DO219774	UCEC	ICGC	RRKKLICVT	DEG_APCC_DBOX_1	0.0556
p.C201R	TCGA-EY-A1GD	UCEC	TCGA	RRKKLICVT	DEG_APCC_DBOX_1	0.719
p.C201R	DO42129	UCEC	ICGC	RRKKLICVT	DEG_APCC_DBOX_1	0.719
p.R195W	DO228650	LICA	ICGC	RRKKLICVT	DEG_APCC_DBOX_1	0.7523
p.R195W	DO52365	LUSC	ICGC	RRKKLICVT	DEG_APCC_DBOX_1	0.7523
p.M212I	DO229213	THCA	ICGC	RRKKLICVT	DEG_APCC_DBOX_1	0.0833
p.T209A	SIDM02026	Colorectal Carcinoma	GDSC	RRKKLICVT	DEG_APCC_DBOX_1	0.1667
p.T209S	ACH-000590	Lung Cancer	CCLE	RRKKLICVT	DEG_APCC_DBOX_1	0.1667
p.T209S	ACH-001137	Lung Cancer	CCLE	RRKKLICVT	DEG_APCC_DBOX_1	0.1667
p.T209S	NCI-H1993	lung	COSMIC	RRKKLICVT	DEG_APCC_DBOX_1	0.1667
p.N199K	ACH-000966	Ovarian Cancer	CCLE	RRKKLICVT	DEG_APCC_DBOX_1	0.6918
p.N199K	IGROV-1	ovary	COSMIC	RRKKLICVT	DEG_APCC_DBOX_1	0.6918
p.E202Q	ACH-002218	Leukemia	CCLE	RRKKLICVT	DEG_APCC_DBOX_1	0.6744
p.E202Q	CESS	haematopoietic_and_lymphoid_tissue	COSMIC	RRKKLICVT	DEG_APCC_DBOX_1	0.6744

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y5Y7	Lymphatic vessel endothelial hyaluronic acid receptor 1	DEG_APCC_DBOX_1	195:203	RRKKLICVT	APC,CDC20,FZR1	0.9487	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RRKKLICVT

Degron related mutations and impact score

Drug responses associated with LYVE1 mutations

All proteins holding degron of RRKKLICVT