DegronMD

Uniprot ID: Q92954

Source protein: Proteoglycan 4

Source gene: PRG4

Class: DEG_SPOP_SBC_1

Location: 734:738

E3 ligase: SPOP

DEGRON score: 0.6542

ASA_SCORE: 93.18

COIL: 0.9584

CONS_SCORE: 0.1583

DSS_SCORE: 0.7917

HELIX: 0.0132

FCONS_SCORE: 0.8392

RIG_SCORE: 0.6085

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K726N	TCGA-BS-A0UF	UCEC	TCGA	APTTT	DEG_SPOP_SBC_1	0.2222
p.K726N	DO41488	UCEC	ICGC	APTTT	DEG_SPOP_SBC_1	0.2222
p.P725L	TCGA-EY-A215	UCEC	TCGA	APTTT	DEG_SPOP_SBC_1	0.0833
p.P725L	DO42665	UCEC	ICGC	APTTT	DEG_SPOP_SBC_1	0.0833
p.T724S	DO224680	BRCA	ICGC	APTTT	DEG_SPOP_SBC_1	0.0556
p.C746S	DO229010	COCA	ICGC	APTTT	DEG_SPOP_SBC_1	0.1111
p.C746S	DO229013	COCA	ICGC	APTTT	DEG_SPOP_SBC_1	0.1111
p.C746S	DO229016	COCA	ICGC	APTTT	DEG_SPOP_SBC_1	0.1111
p.C746S	DO229003	COCA	ICGC	APTTT	DEG_SPOP_SBC_1	0.1111
p.C746S	DO229005	COCA	ICGC	APTTT	DEG_SPOP_SBC_1	0.1111
p.L733P	DO228945	LICA	ICGC	APTTT	DEG_SPOP_SBC_1	0.3056
p.L733P	DO224610	LUSC	ICGC	APTTT	DEG_SPOP_SBC_1	0.3056
p.E740G	DO50827	LIRI	ICGC	APTTT	DEG_SPOP_SBC_1	0.2778
p.E729G	JURL-MK1	haematopoietic_and_lymphoid_tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	0.1944
p.E729G	SK-MEL-30	skin	COSMIC	APTTT	DEG_SPOP_SBC_1	0.1944
p.E729G	UACC-62	skin	COSMIC	APTTT	DEG_SPOP_SBC_1	0.1944
p.P732T	SK-MEL-30	skin	COSMIC	APTTT	DEG_SPOP_SBC_1	0.2778
p.P732T	UACC-62	skin	COSMIC	APTTT	DEG_SPOP_SBC_1	0.2778
p.P732T	JURL-MK1	haematopoietic_and_lymphoid_tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	0.2778
p.P724T	SK-MEL-30	skin	COSMIC	APTTT	DEG_SPOP_SBC_1	0.0556
p.P724T	EKVX	lung	COSMIC	APTTT	DEG_SPOP_SBC_1	0.0556
p.P724T	JURL-MK1	haematopoietic_and_lymphoid_tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	0.0556
p.P724T	UACC-62	skin	COSMIC	APTTT	DEG_SPOP_SBC_1	0.0556
p.E731G	SK-MEL-30	skin	COSMIC	APTTT	DEG_SPOP_SBC_1	0.3611
p.E731G	UACC-62	skin	COSMIC	APTTT	DEG_SPOP_SBC_1	0.3611
p.E731G	JURL-MK1	haematopoietic_and_lymphoid_tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	0.3611
p.P730T	SK-MEL-30	skin	COSMIC	APTTT	DEG_SPOP_SBC_1	0.2222
p.P730T	JURL-MK1	haematopoietic_and_lymphoid_tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	0.2222
p.P730T	UACC-62	skin	COSMIC	APTTT	DEG_SPOP_SBC_1	0.2222
p.E747K	Sarc9371	bone	COSMIC	APTTT	DEG_SPOP_SBC_1	0.0833
p.E729K	NCI-H1573	lung	COSMIC	APTTT	DEG_SPOP_SBC_1	0.1944
p.E731K	NCI-H1573	lung	COSMIC	APTTT	DEG_SPOP_SBC_1	0.3611
p.P726T	EKVX	lung	COSMIC	APTTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	DEG_SPOP_SBC_1	1556:1560	APTTT	SPOP	0.999	More...
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	777:781	APTTT	SPOP	0.9974	More...
O00257	E3 SUMO-protein ligase CBX4	DEG_SPOP_SBC_1	510:514	APTTT	SPOP	0.9085	More...
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	741:745	APTTT	SPOP	0.9972	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1822:1826	APTTT	SPOP	0.9757	More...
O96005	Cleft lip and palate transmembrane protein 1	DEG_SPOP_SBC_1	626:630	APTTT	SPOP	0.9015	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1323:1327	APTTT	SPOP	0.628	More...
Q5T4S7	E3 ubiquitin-protein ligase UBR4	DEG_SPOP_SBC_1	2466:2470	APTTT	SPOP	0.88	More...
Q6SA08	Testis-specific serine/threonine-protein kinase 4	DEG_SPOP_SBC_1	10:14	APTTT	SPOP	0.7213	More...
Q6UXF1	Transmembrane protein 108	DEG_SPOP_SBC_1	265:269	APTTT	SPOP	0.9989	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	382:386	APTTT	SPOP	0.9417	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	397:401	APTTT	SPOP	0.7673	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	413:417	APTTT	SPOP	0.8995	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	421:425	APTTT	SPOP	0.9979	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	507:511	APTTT	SPOP	0.9358	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	523:527	APTTT	SPOP	0.9092	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	530:534	APTTT	SPOP	0.9944	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	538:542	APTTT	SPOP	0.9813	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	593:597	APTTT	SPOP	0.9962	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	734:738	APTTT	SPOP	0.6542	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	803:807	APTTT	SPOP	0.9052	More...
Q96AE4	Far upstream element-binding protein 1	DEG_SPOP_SBC_1	559:563	APTTT	SPOP	0.9606	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	800:804	APTTT	SPOP	0.9952	More...
Q9Y5Y7	Lymphatic vessel endothelial hyaluronic acid receptor 1	DEG_SPOP_SBC_1	180:184	APTTT	SPOP	0.926	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	384:388	APTTT	SPOP	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APTTT

Degron related mutations and impact score

Drug responses associated with PRG4 mutations

All proteins holding degron of APTTT