DegronMD

Uniprot ID: Q92954

Source protein: Proteoglycan 4

Source gene: PRG4

Class: DEG_SPOP_SBC_1

Location: 507:511

E3 ligase: SPOP

DEGRON score: 0.9358

ASA_SCORE: 96.76

COIL: 0.961

CONS_SCORE: 0.43

DSS_SCORE: 0.823

HELIX: 0.0142

FCONS_SCORE: 0.8967

RIG_SCORE: 0.5372

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P508H	TCGA-33-4566	LUSC	TCGA	APTTT	DEG_SPOP_SBC_1	0.6583
p.P508H	DO26790	LUSC	ICGC	APTTT	DEG_SPOP_SBC_1	0.6583
p.P519L	TCGA-55-A490	LUAD	TCGA	APTTT	DEG_SPOP_SBC_1	0.1111
p.P519L	DO24596	LUAD	ICGC	APTTT	DEG_SPOP_SBC_1	0.1111
p.T510A	TCGA-BR-4368	STAD	TCGA	APTTT	DEG_SPOP_SBC_1	0.7139
p.T510A	DO38715	STAD	ICGC	APTTT	DEG_SPOP_SBC_1	0.7139
p.K504N	TCGA-P3-A6T2	HNSC	TCGA	APTTT	DEG_SPOP_SBC_1	0.3611
p.K504N	DO49034	HNSC	ICGC	APTTT	DEG_SPOP_SBC_1	0.3611
p.T511P	DO222718	COCA	ICGC	APTTT	DEG_SPOP_SBC_1	0.8142
p.T511P	DO222839	COCA	ICGC	APTTT	DEG_SPOP_SBC_1	0.8142
p.T511P	DO230548	LUSC	ICGC	APTTT	DEG_SPOP_SBC_1	0.8142
p.T511P	DO231067	LUSC	ICGC	APTTT	DEG_SPOP_SBC_1	0.8142
p.A507S	DO230554	LUSC	ICGC	APTTT	DEG_SPOP_SBC_1	0.7588
p.A507S	KYSE-180	oesophagus	COSMIC	APTTT	DEG_SPOP_SBC_1	0.7588
p.S515A	DO230554	LUSC	ICGC	APTTT	DEG_SPOP_SBC_1	0.2222
p.K504E	DO229216	THCA	ICGC	APTTT	DEG_SPOP_SBC_1	0.3611
p.P503H	SIDM00282	Colorectal Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	0.2222
p.P503H	ACH-000998	Colon/Colorectal Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	0.2222
p.P503H	CW-2	large_intestine	COSMIC	APTTT	DEG_SPOP_SBC_1	0.2222
p.T517I	SIDM00709	Non-Small Cell Lung Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	0.1667
p.T517I	ACH-000451	Lung Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	0.1667
p.T517I	ACH-001547	Lung Cancer	CCLE	APTTT	DEG_SPOP_SBC_1	0.1667
p.P506S	SIDM01443	Gastric Carcinoma	GDSC	APTTT	DEG_SPOP_SBC_1	0.3056
p.T521I	KINGS-1	central_nervous_system	COSMIC	APTTT	DEG_SPOP_SBC_1	0.0556
p.S501P	KYSE-180	oesophagus	COSMIC	APTTT	DEG_SPOP_SBC_1	0.6111
p.S510A	HeLa	cervix	COSMIC	APTTT	DEG_SPOP_SBC_1	0.7588
p.S510A	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	0.7588
p.A520S	KM12	large_intestine	COSMIC	APTTT	DEG_SPOP_SBC_1	0.1944
p.S512A	HeLa	cervix	COSMIC	APTTT	DEG_SPOP_SBC_1	0.3056
p.S512A	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	APTTT	DEG_SPOP_SBC_1	0.3056
p.A518S	KM12	large_intestine	COSMIC	APTTT	DEG_SPOP_SBC_1	0.5833
p.S503P	KYSE-180	oesophagus	COSMIC	APTTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	DEG_SPOP_SBC_1	1556:1560	APTTT	SPOP	0.999	More...
A8CG34	Nuclear envelope pore membrane protein POM 121C	DEG_SPOP_SBC_1	777:781	APTTT	SPOP	0.9974	More...
O00257	E3 SUMO-protein ligase CBX4	DEG_SPOP_SBC_1	510:514	APTTT	SPOP	0.9085	More...
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	741:745	APTTT	SPOP	0.9972	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1822:1826	APTTT	SPOP	0.9757	More...
O96005	Cleft lip and palate transmembrane protein 1	DEG_SPOP_SBC_1	626:630	APTTT	SPOP	0.9015	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1323:1327	APTTT	SPOP	0.628	More...
Q5T4S7	E3 ubiquitin-protein ligase UBR4	DEG_SPOP_SBC_1	2466:2470	APTTT	SPOP	0.88	More...
Q6SA08	Testis-specific serine/threonine-protein kinase 4	DEG_SPOP_SBC_1	10:14	APTTT	SPOP	0.7213	More...
Q6UXF1	Transmembrane protein 108	DEG_SPOP_SBC_1	265:269	APTTT	SPOP	0.9989	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	382:386	APTTT	SPOP	0.9417	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	397:401	APTTT	SPOP	0.7673	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	413:417	APTTT	SPOP	0.8995	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	421:425	APTTT	SPOP	0.9979	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	507:511	APTTT	SPOP	0.9358	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	523:527	APTTT	SPOP	0.9092	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	530:534	APTTT	SPOP	0.9944	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	538:542	APTTT	SPOP	0.9813	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	593:597	APTTT	SPOP	0.9962	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	734:738	APTTT	SPOP	0.6542	More...
Q92954	Proteoglycan 4	DEG_SPOP_SBC_1	803:807	APTTT	SPOP	0.9052	More...
Q96AE4	Far upstream element-binding protein 1	DEG_SPOP_SBC_1	559:563	APTTT	SPOP	0.9606	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	800:804	APTTT	SPOP	0.9952	More...
Q9Y5Y7	Lymphatic vessel endothelial hyaluronic acid receptor 1	DEG_SPOP_SBC_1	180:184	APTTT	SPOP	0.926	More...
A6NF01	Putative nuclear envelope pore membrane protein POM 121B	DEG_SPOP_SBC_1	384:388	APTTT	SPOP	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: APTTT

Degron related mutations and impact score

Drug responses associated with PRG4 mutations

All proteins holding degron of APTTT